Association between mannose binding lectin gene polymorphisms and clinical severity of COVID-19 in children

Yilmaz, Dilek; Soyoz, Mustafa; Sahin, Aslıhan; Cerci-Alkac, Burcu; Karahan-Coven, Hatice Ilayhan; Ekemen-Keles, Yıldız; Ustundag, Gulnihan; Kara-Aksay, Ahu; Yilmaz, Nisel; Pirim, İbrahim

doi:10.1007/s11033-023-08524-z

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…In a study carried out in South Africa, it was observed that MBL2 gene polymorphisms were associated with increased susceptibility to infection and humoral IgG response to C. trachomatis infection (p = 0.048) (Verweij et al, 2022). In this other study, an association of polymorphisms in codon 54 (A/B or B/B) was observed with the development of more severe symptoms of COVID-19 in children in a Turkish city (Yilmaz et al, 2023). Molle et al (2006) found that multiple myeloma (MM) patients with the A/A genotype had a reduced risk of septicemia after autologous stem cell transplantation (Mølle et al, 2006).…”

Section: Discussionmentioning

confidence: 71%

Impact of Exon 1 Polymorphism in the MBL2 Gene on MBL Serum Levels and Infection Susceptibility in Acute Lymphoid Leukemia

Oliveira,

Barbosa,

Mineiro

et al. 2024

Preprint

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Polymorphisms in the MBL2 gene exon 1 can decrease serum levels of mannose-binding lectin (MBL), increasing the risk of infection in immunocompromised individuals. This study evaluated the association between the polymorphism in exon 1 of the MBL2 gene, genotypes, serum MBL levels, and infection in 122 patients with acute lymphoid leukemia (ALL). The MBL*A allele exhibited the highest frequency (0.37) within the study population. The MBL*D (0.32) was the predominant variant. The combined frequency of O polymorphic alleles (either B or D) was 0.63. The frequencies of the A/A, A/O and O/O genotypes were 0.13, 0.49 and 0.38, respectively. All patients exhibited consistently low levels of serum MBL, irrespective of their exon 1 genotype. Parasitic infections (n = 103), bacterial (n = 69) and viral (n = 48). A/O genotype (0.49) had higher infection rates, A/A (0.13) had lower rates, and O/O showed increased viral susceptibility (OR: 0.37; 95% CI 0.13–1.06; p = 0.05). Our findings demonstrated that the study population were MBL-deficient, regardless of their MLB2 genotype. Individuals with the A/O genotype had more infections, while those with the O/O genotype appeared more susceptible to viral infections. These findings highlight the impact of MBL levels and genetic variants on infection susceptibility in ALL patients.

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Section: Discussionmentioning

confidence: 71%

Impact of Exon 1 Polymorphism in the MBL2 Gene on MBL Serum Levels and Infection Susceptibility in Acute Lymphoid Leukemia

Oliveira,

Barbosa,

Mineiro

et al. 2024

Preprint

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High production MBL2 polymorphisms protect against COVID-19 complications in critically ill patients: A retrospective cohort study

de Andrade,

de Souza Sá,

Vasconcelos

et al. 2024

Heliyon

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The MBL2 genotype relates to COVID-19 severity and may help to select the optimal therapy

Scialò

Cernera

Esposito

et al. 2023

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives Sars-CoV-2 acute infection is clinically heterogeneous, ranging from asymptomatic cases to patients with a severe, systemic clinical course. Among the involved factors age and preexisting morbidities play a major role; genetic host susceptibility contributes to modulating the clinical expression and outcome of the disease. Mannose-binding lectin is an acute-phase protein that activates the lectin-complement pathway, promotes opsonophagocytosis and modulates inflammation, and is involved in several bacterial and viral infections in humans. Understanding its role in Sars-CoV-2 infection could help select a better therapy. Methods We studied MBL2 haplotypes in 419 patients with acute COVID-19 in comparison to the general population and related the haplotypes to clinical and laboratory markers of severity. Results We recorded an enhanced frequency of MBL2 null alleles in patients with severe acute COVID-19. The homozygous null genotypes were significantly more frequent in patients with advanced WHO score 4–7 (OR of about 4) and related to more severe inflammation, neutrophilia, and lymphopenia. Conclusions Subjects with a defective MBL2 genotype (i.e., 0/0) are predisposed to a more severe acute Sars-CoV-2 infection; they may benefit from early replacement therapy with recombinant MBL. Furthermore, a subset of subjects with the A/A MBL genotype develop a relevant increase of serum MBL during the early phases of the disease and develop a more severe pulmonary disease; in these patients, the targeting of the complement may help. Therefore, COVID-19 patients should be tested at hospitalization with serum MBL analysis and MBL2 genotype, to define the optimal therapy.

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Association between mannose binding lectin gene polymorphisms and clinical severity of COVID-19 in children

Cited by 4 publications

References 36 publications

Impact of Exon 1 Polymorphism in the MBL2 Gene on MBL Serum Levels and Infection Susceptibility in Acute Lymphoid Leukemia

Impact of Exon 1 Polymorphism in the MBL2 Gene on MBL Serum Levels and Infection Susceptibility in Acute Lymphoid Leukemia

High production MBL2 polymorphisms protect against COVID-19 complications in critically ill patients: A retrospective cohort study

The MBL2 genotype relates to COVID-19 severity and may help to select the optimal therapy

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