Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk

Mitrunen, Katja; Sillanpää, Pia; Kataja, Vesa; Eskelinen, Matti; Kosma, Veli Matti; Benhamou, Simone; Uusitupa, Matti; Hirvonen, Ari

doi:10.1093/carcin/22.5.827

Cited by 215 publications

(166 citation statements)

References 9 publications

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“…Our data showed that the Ala carriers had an increased risk of prostate and esophageal cancer. In support of this finding, the MnSOD Ala/Ala genotype was associated with a 1.7-fold increased risk for prostate cancer (Woodson et al, 2001), 1.9-fold increased risk for esophageal cancer (Murphy et al, 2007), and significantly elevated risk for breast cancer (Mitrunen et al, 2001). Molecularly, the MnSOD Ala/Ala genotype causes an amino acid substitution from valine (Val) to alanine (Ala),which reduces MnSOD enzymatic activity and its ability to remove ROS (Sutton et al, 2003).…”

Section: Discussionmentioning

confidence: 90%

“…The inefficient MnSOD protein in the mitochondria may leave the cell vulnerable to oxidative damage without its full defense against superoxide radicals, which leads to protein oxidation and DNA mutations (Ambrosone et al, 1999). The Ala variant of the MnSOD protein has been reported to increase risk of several types of malignancies, such as breast cancer (Mitrunen et al, 2001), prostate cancer (Choi et al, 2008), esophageal cancer (Murphy et al, 2007), and cervical cancer (Tong et al 2009), and additional studies showed that it is likely to be associated with alteration of ROS and thus predisposed to a lower risk of liver (Sutton et al, 2003), lung (Wang et al, 2001), and bladder (Hung et al, 2004) cancers. The discrepancy may be partially due to minor effect of this gene polymorphism on cancer risk, or the small sample size reported in each study.…”

Section: Introductionmentioning

confidence: 99%

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Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Sun

Wang²,

Lu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Altered expression or function of manganese superoxide dismutase (MnSOD) has been shown to be associated with cancer risk but assessment of gene polymorphisms has resulted in inconclusive data. Here a search of published data was made and 22 studies were recruited, covering 20,025 case and control subjects, for metaanalyses of the association of MnSOD polymorphisms with the risk of prostate, esophageal, and lung cancers. The data on 12 studies of prostate cancer (including 4,182 cases and 6,885 controls) showed a statistically significant association with the risk of development in co-dominant models and dominant models, but not in the recessive model. Subgroup analysis showed there was no statistically significant association of MnSOD polymorphisms with aggressive or nonaggressive prostate cancer in different genetic models. In addition, the data on four studies of esophageal cancer containing 620 cases and 909 controls showed a statistically significant association between MnSOD polymorphisms and risk in all comparison models. In contrast, the data on six studies of lung cancer with 3,375 cases and 4,050 controls showed that MnSOD polymorphisms were significantly associated with the decreased risk of lung cancer in the homozygote and dominant models, but not the heterozygote model. A subgroup analysis of the combination of MnSOD polymorphisms with tobacco smokers did not show any significant association with lung cancer risk, histological type, or clinical stage of lung cancer. The data from the current study indicated that the Ala allele MnSOD polymorphism is associated with increased risk of prostate and esophageal cancers, but with decreased risk of lung cancer. The underlying molecular mechanisms warrant further investigation.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Sun

Wang²,

Lu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…17 Therefore, because of the use of oral contraception in the African female group, the multiple regression analyses were repeated by additionally adjusting for oral contraception. By doing so, the results remained unchanged.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study

et al. 2011

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Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory blood pressure measurements were taken for 101 black South African men and 99 women. The stiffness indices included ambulatory arterial stiffness index (AASI) and pulse pressure (PP). Reactive oxygen species (ROS) levels (Po0.0001) were higher in the African women compared with men. ROS levels were also higher in hypertensive compared with normotensive men. The 24 h systolic blood pressure (SBP; Po0.01), 24 h diastolic blood pressure (DBP; Po0.0001) and pulse wave velocity (PWV; Po0.01) were significantly higher in African men compared with women. There were unadjusted positive associations of 24 h SBP (r ¼ 0.33; P ¼ 0.001), 24 h DBP (r ¼ 0.26; P ¼ 0.008) and 24 h PP (r ¼ 0.29; P ¼ 0.003) with ROS in African men only. A positive association between AASI and ROS existed only in hypertensive men (r ¼ 0.27; P ¼ 0.035), but became nonsignificant (B ¼ 0.0014; P ¼ 0.14) after adjustments. Adjusted, positive associations of 24 h SBP (B ¼ 0.181; P ¼ 0.018) and 24 h PP (B ¼ 0.086; P ¼ 0.050) with ROS were again only evident in African men. ROS is positively associated with SBP and PP in African men, suggesting that increased ROS levels may contribute to hypertension in this population group.

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“…18 It has been shown that Mn-SOD genotypes containing the variant A allele were found to be associated with a 1.5-fold increased risk of breast cancer compared with those with the homozygous wild-type genotype (Mn-SOD VV). 17 Taysi et al 7 found that erythrocyte SOD activities were increased in BD compared to healthy controls whereas the other antioxidant enzymes, glutathione S transferase, catalase, and GPx were decreased. In another study, which investigated the oxidant-antioxidant status in whole blood from BD and controls, GPx was found to be decreased similarly to the previous paper.…”

Section: Discussionmentioning

confidence: 99%

“…[16][17][18] Oligonucleotides were purchased from Iontek (Iontek Medical A.. Moleküler Biyoloji ve Genetik Laboratuvarı, Istanbul, Turkey).…”

Section: Methodsmentioning

confidence: 99%

Genetic Polymorphism of Manganese Superoxide Dismutase in Behçet’s Disease

Yılmaz

Yağcı

et al. 2016

Arch Rheumatol

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Objectives: This study aims to investigate the genetic association between single nucleotide mutation in mitochondrial manganese superoxide dismutase and a Behçet's disease (BD) population by using molecular techniques. Patients and methods: Ninety-three BD patients (45 males, 48 females; mean age 33.15±8.99 years; range 17 to 65 years) and 125 controls (58 males, 67 females; mean age 28.33±7.31 years; range 18 to 62 years) were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. The genotypic distributions in BD patients and controls were consistent with the Hardy-Weinberg equilibrium. Results: Significant differences were observed between BD patients and controls in terms of genotypic distribution. Frequencies of alanine (Ala)/Ala, Ala/valine (Val), and Val/Val were 14.0% (n=13), 45.2% (n=42), and 40.9% (n=38) in BD patients and 21.6% (n=27), 53.6% (n=67), and 24.8% (n=31) in controls, respectively (p=0.033). Conclusion:The Val/Val genotype of the manganese superoxide dismutase gene is associated with the physiopathology of BD in a group of Turkish patients.Keywords: Behçet's disease; manganese superoxide dismutase; polymerase chain reaction-restriction fragment length polymorphism; polymorphism.Behçet's disease (BD) is a chronic, multi-systemic, relapsing, and inflammatory disorder characterized by ocular manifestations, in particular. 1 It is also characterized by uveitis, recurrent oral ulceration, genital ulceration, and skin lesions. BD exists worldwide, but it is relatively more widespread in Middle Eastern and East Asian countries including Japan. 2 The effect of autoimmune response and genetic factors on etiology of BD was well established. 2 However, the etiologic mechanisms underlying this vascular disease have not been well understood yet. Reactive oxygen species (ROS) have been hypothesized to play an important role in BD. Evidence from several studies suggests that neutrophils from patients with BD generate high levels of ROS and then this stress causes endothelial cell lysis in vitro. [3][4][5] On the other hand, different data reported in the literature show a variation for the activities of antioxidant enzymes in BD: erythrocyte superoxide dismutase (SOD) activity was found to be increased, 4,6,7 unchanged, 8 and decreased, 5,9

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Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk

Cited by 215 publications

References 9 publications

Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study

Genetic Polymorphism of Manganese Superoxide Dismutase in Behçet’s Disease

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