Association between Malnutrition Assessed by the Global Leadership Initiative on Malnutrition Criteria and Mortality in Older People: A Scoping Review

Sánchez-Rodríguez, Dolores; Meester, Dorien De; Minon, Léa; Claessens, Marie; Gümüs, Neslian; Lieten, Siddhartha; Benoit, Florence; Surquin, Murielle; Marco, Ester

doi:10.3390/ijerph20075320

Cited by 9 publications

(4 citation statements)

References 40 publications

(149 reference statements)

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“…The skeletal muscle mass index (SMI) serves as a key indicator in evaluating the nutritional status of patients, with low skeletal muscle mass commonly identi ed as sarcopenia. 13,14 The present study found that patients with sarcopenia exhibited signi cantly lower OS rates compared to those without sarcopenia, suggesting sarcopenia as a negative prognostic factor for individuals with laNPC. The underlying reasons for this association may be multifactorial.…”

Section: Discussionsupporting

confidence: 47%

“…The Skeletal Muscle Mass Index (SMI) serve as key indicators for evaluating patients' nutritional statuses. 13 Within the Global Leadership Initiative on Malnutrition (GLIM) consensus, low skeletal muscle mass, known as sarcopenia, is a diagnostic criterion for malnutrition in hospitalized patients. 14 The SMI is typically calculated by evaluating the cross-sectional area of skeletal muscle tissue at the third lumbar vertebra (L3) in abdominal images and dividing by the square of height (cm2/m2).…”

Section: Introductionmentioning

confidence: 99%

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Predicting the risk of sarcopenia in Nasopharyngeal Carcinoma patients: Development and assessment of a new predictive nomogram

Liu,

Wang,

Chen

et al. 2024

Preprint

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Purpose Sarcopenia, as defined by the Global Leadership Initiative on Malnutrition (GLIM) consensus, serves as a diagnostic indicator for malnutrition and has been shown to influence cancer treatment and clinical results. However, the impact of sarcopenia on individuals diagnosed with nasopharyngeal carcinoma (NPC) remain insufficiently elucidated. The objective of this study was to investigate the prognostic significance of sarcopenia on the survival outcomes of NPC patients and to develop a nomogram. Patients and methods: 545 patients with stage III-IVa NPC were included in this retrospective study and randomly divided into training and validation cohort (381 and 164 patients, respectively). Sarcopenia was defined using the skeletal muscle index (SMI) determined at the C3 level based on baseline MRI. The nomogram was developed utilizing a multivariable Cox model with baseline variables from the training cohort, and validated with the validation cohort. The nomogram's discriminative ability and accuracy were evaluated using the consistency index (C-index), receiver operating characteristic curve (ROC), and calibration plots, while the net benefit was assessed and compared with the TNM clinical stage through decision curve analysis (DCA). Results The results of the multivariate analysis revealed that higher T stage (HR = 2.15, 95% CI: 1.3–3.57, P < 0.01), higher N stage (HR = 2.15, 95% CI: 1.56–2.95, P < 0.01), sarcopenia group (HR = 2.46, 95% CI: 1.58–3.83, P < 0.01), and a history of comorbidities (HR = 1.76, 95% CI: 1.16–2.67, P = 0.01) were identified as independent risk factors that significantly impacted both overall survival (OS). The C-index (0.731 for the training cohort and 0.72 for the validation cohort indicated satisfactory discriminative ability of the nomogram. The calibration plots showed favorable consistency between the prediction of the nomogram and actual observations in both the training and validation cohorts. Moreover, nomograms also showed higher outcomes of DCA and the area under the curve (AUC) compared to TNM clinical stage. Conclusion Sarcopenia, T stage, N stage, and comorbidities were identified as independent prognostic factors for locally advanced NPC (laNPC). The integration of these factors into a nomogram predictive model demonstrated enhanced predictive accuracy.

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Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Predicting the risk of sarcopenia in Nasopharyngeal Carcinoma patients: Development and assessment of a new predictive nomogram

Liu,

Wang,

Chen

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…There are to date only a limited number of studies examining the contribution of the so-called phenotypic and etiologic factors used by GLIM to allcause mortality. 20,21 The objective of the current study was to assess the association between either risk of malnutrition (by NRS 2002) or malnutrition according to the diagnostic assessment of GLIM with all-cause mortality in hospitalized patients during a 2-year follow-up. Further, we wanted to investigate which of the phenotypic and etiologic criteria were associated with mortality in our population.…”

Section: Introductionmentioning

confidence: 99%

Malnutrition as a prognostic factor for 2‐year mortality in hospitalized patients in Norway: A matched cohort study

Trollebø,

Tangvik,

Skeie

et al. 2024

J Parenter Enteral Nutr

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BackgroundRisk of malnutrition and malnutrition have been previously associated with increased risk of mortality. It remains unclear, however, whether the severity of malnutrition differentiates in association with all‐cause mortality. The aim was to assess the association between being at risk of malnutrition or being diagnosed with malnutrition according to the diagnostic assessment of the Global Leadership Initiative on Malnutrition (GLIM) with all‐cause mortality during a 2‐year follow‐up in hospitalized patients.MethodsA matched cohort study was conducted in hospitalized patients (excluding cancer, intensive care, and transmissible infections) at a university hospital in Bergen, Norway. All patients underwent nutrition screening with the Nutritional Risk Screening 2002 and a further nutrition assessment using the GLIM criteria. All‐cause mortality was estimated from the Norwegian death registry after 2 years, and risk factors were calculated by Cox regression analysis.ResultsAmong 326 patients included, 55 patients died within 2 years (17% mortality rate). Risk of malnutrition was associated with increased all‐cause mortality, which disappeared after adjustment for age and sex. Malnutrition was associated with an increased risk of all‐cause mortality at 2 years also after adjustment for age and sex and, additionally, for further comorbidities (hazard ratio = 2.50; 95% CI, 1.41–4.42). When analyzed separately only severe malnutrition was associated with mortality (hazard ratio = 2.73; 95% CI, 1.44–5.15).ConclusionThe findings highlight a strong association between inpatients with severe malnutrition, defined by the GLIM criteria, and an increased risk of all‐cause mortality within a 2‐year follow‐up.

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“…Anticoagulation treatment has been linked to lower all-cause mortality in community-dwelling older adults with atrial fibrillation, regardless of their health and functional condition ( Pilotto et al, 2016 ), showcasing the potential impact of therapeutic interventions on life expectancy. Malnutrition, evaluated by the Global Leadership Initiative on Malnutrition criteria, strongly correlates with mortality in both hospitalized and community-dwelling older individuals ( Sánchez-Rodríguez et al, 2023 ), underscoring the critical role of nutritional status. A decline in physical performance, as shown by finger tap reaction time, has been established as a risk factor for mortality and disability in older adults ( Shim et al, 2017 ), emphasizing the significance of assessing motor function in prognostic evaluations.…”

Section: Introductionmentioning

confidence: 99%

Serum Albumin as Prognostic Marker for Older Adults in Hospital and Community Settings

Riviati,

Legiran,

Indrajaya

et al. 2024

Gerontology and Geriatric Medicine

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Serum albumin, known for its multifaceted role in health, is hypothesized to serve as a prognostic marker for older adults, both in hospital and community settings. Nine studies were included in the review, revealing consistent associations between low serum albumin levels and increased mortality risk in hospitalized older individuals. In community settings, low serum albumin levels were linked to higher mortality rates compared to those with normal levels. The synthesis of evidence underscores the potential of serum albumin as a prognostic marker for older adults, offering valuable insights for risk stratification and targeted interventions. While robust evidence supports its utility in hospital settings, further research is warranted in community settings to address current limitations and enhance the applicability of serum albumin as a prognostic tool. This review merges existing knowledge of the prognostic significance of serum albumin in older adults across hospital and community settings. The findings emphasize the importance of serum albumin as a potential prognostic marker, urging continued research efforts to refine its application in diverse healthcare contexts and improve outcomes for the aging population.

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Association between Malnutrition Assessed by the Global Leadership Initiative on Malnutrition Criteria and Mortality in Older People: A Scoping Review

Cited by 9 publications

References 40 publications

Predicting the risk of sarcopenia in Nasopharyngeal Carcinoma patients: Development and assessment of a new predictive nomogram

Predicting the risk of sarcopenia in Nasopharyngeal Carcinoma patients: Development and assessment of a new predictive nomogram

Malnutrition as a prognostic factor for 2‐year mortality in hospitalized patients in Norway: A matched cohort study

Serum Albumin as Prognostic Marker for Older Adults in Hospital and Community Settings

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