Association between magnesium status, oxidative stress and inflammation in preeclampsia: A case–control study

Rocha, Vivianne de Sousa; Rosa, Fernanda Brunacci Della; Ruano, Rodrigo; Zugaib, Marcelo; Colli, Célia

doi:10.1016/j.clnu.2014.12.001

Cited by 23 publications

(10 citation statements)

References 22 publications

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“…Women in the lowest tertile of the estimated average intake of magnesium showed decreased expression of placental GPx4. Consistently, in pregnant women with preeclampsia, a correlation has been found between GPx activity and plasmatic concentration of magnesium [24]. Evidence from animal studies shows that the activity of GPx is lower in the liver of rats with a magnesium-deficient diet [25].…”

Section: Discussionmentioning

confidence: 84%

Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit

Ballesteros-Guzmán

Legleu

Levario-Carrillo

et al. 2019

BioMed Research International

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Background. Obesity and pregnancy increase levels of maternal oxidative stress (OS). However, little is known about the maternal, placental, and neonatal OS status. Objective. To analyze the relation between prepregnancy obesity and the expression of OS markers and antioxidant capacity in the fetomaternal unit and their association with dietary intake. Methods. This cross-sectional study included 33 women with singleton, noncomplicated pregnancies. Two groups were formed: women with prepregnancy body mass index (pBMI) within normal range (18.5-24.9 kg/m2, n = 18) and women with pBMI ≥ 30 kg/m2, suggestive of obesity (n = 15). Dietary and clinical information was obtained by questionnaire and from clinical records. Total antioxidant capacity (TAC) and malondialdehyde (MDA) concentration were measured on maternal and cord serum by colorimetric techniques, and placental expression of glutathione peroxidase 4 (GPx4) was measured by immunohistochemistry. Results. Placental GPx4 expression was lower in the group with pBMI suggestive of obesity than in the normal weight group (ß = -0.08, p = 0.03, adjusted for gestational age and magnesium intake). Concentrations of TAC and MDA in maternal and cord blood were not statistically different between groups (p>0.05). Cord MDA concentration was related to maternal MDA concentration (ß = 0.40, p < 0.01), vitamin A intake (tertile 2: ß = -0.04, p = 0.40, tertile 3: ß = 0.13, p = 0.03, vs tertile 1), and placental GPx4 expression (ß = -0.09, p = 0.02). Conclusion. Prepregnancy obesity is associated with a decrease in GPx4 expression in the placenta, which is related to OS in the newborn. The influence of micronutrient intake on OS biomarkers highlights the importance of nutritional assessment during pregnancy and adequate prenatal care.

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Section: Discussionmentioning

confidence: 84%

Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit

Ballesteros-Guzmán

Legleu

Levario-Carrillo

et al. 2019

BioMed Research International

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“…In this regard, the information available in the literature supports the sensitivity of P. vulgaris to water shortage, especially during flowering initiation and development. Water stress during these stages results in excessive flowering, premature pods, and the abortion of seeds, which directly affect the final yield . Also, sustained deficit irrigation has been related to a reduction of the aboveground biomass and a lower number of pods and seeds per pod.…”

Section: Discussionmentioning

confidence: 99%

The Value of Legume Foods as a Dietary Source of Phytoprostanes and Phytofurans Is Dependent on Species, Variety, and Growing Conditions

García‐García

Río-Celestino

Gil‐Izquierdo

et al. 2019

Euro J Lipid Sci & Tech

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Bioactive phytoprostanes and phytofurans are synthesized in higher plants by non‐enzymatic oxidation of α‐linolenic acid (C18:3 n‐3), triggered by high concentrations of reactive oxygen species. In the current scenario of changing dietary patterns, additional information is needed on the concentrations of oxylipins in legumes and on the effect of sustained deficit irrigation on their concentration. The main objective of the work is to elucidate the phytoprostane and phytofuran profile (including eight and three compounds, respectively) of three Pisum sativum cultivars (“mangetout” (ssp. arvense), “BGE‐033620,” and “Lincoln”) and Phaseolus vulgaris (French bean cv. “Helda”), to unravel the oxidative response of these crops to sustained irrigation deficit in terms of oxidative stress, as well as in their importance as healthy dietary sources of new bioactive compounds. Phytoprostanes and phytofurans vary between varieties and species, with 9‐F1t‐PhytoP and ent‐16‐(RS)‐13‐epi‐ST‐Δ14‐9‐PhytoF being the most abundant. The level of phytoprostanes and phytofurans is also determined in sustained deficit irrigation (50% water needed), revealing modifications of their profile and concentration. In conclusion, bioactive phytoprostanes and phytofurans are present in legumes in high concentrations, being further modified by abiotic stress growing conditions, highlighting the importance of this plant food as a dietary source of these bioactive molecules. Practical Applications: This work is of high relevance from the lipidomic point of view, given that phytoprostanes and phytofurans have been promoted as new bioactive secondary metabolites due to their structural analogy with mammal oxylipins. These compounds can be further postulated as possible markers for the monitoring of the physiological status of legume plants under different agronomical conditions. The results obtained can contribute to the successful development of future research in the field of plant physiology and nutrition, significantly contributing to the advance of the current knowledge on the biological role of phytoprostanes and phytofurans in plants and complex biological systems. Species‐dependent modification of phytoprostanes and phytofurans by deficit irrigation in French‐bean, pea, and mangetout.

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“…This is due to increased production and secretion of pro-inflammatory adipokines by the adipose tissue, such as tumor necrosis factor alpha and interleukin 6 [21]. Additionally, excessive weight is directly related to oxidative stress, due to the intracellular accumulation of triglycerides, leading to mitochondrial dysfunction, a situation caused by the increase of electron transport and the generation of reactive oxygen and nitrogen species, potentializing the inflammatory process [22].…”

Section: Discussionmentioning

confidence: 99%

Intake of antioxidants nutrients by pregnant womem: Associated factors

et al. 2018

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Objective To evaluate the intake of antioxidant nutrients by pregnant women being cared for in the Brazilian public health system and associated factors. Methods A cross-sectional study was carried out with pregnant women cared for in the public health system in the city of Maceió, Brazil, in 2014, including 385 pregnant women and their newborns, and the collection of maternal information (socioeconomic, personal, prenatal, dietary and anthropometric data), and after the babies’ birth (gestational age, birth weight and length). Food intake was assessed by two 24-hour dietary reminders per pregnant woman with subsequent adjustments by the Estimated Average Requirement method. Data were processed and Pearson’s correlation was used to evaluate associations, considering p<0.05 as significant. Results A total of 388 pregnant women with a mean age of 24.06±5.92 years were studied, with inadequate intake and high variation of the following antioxidants: vitamin A (83.2%/62.7%), vitamin C (50.5%/75.7%), vitamin E (76.5%/60.2%), Selenium (60.8%/50.3%), Copper (98.5%/42.8%) and Zinc (79.6%/43.4%), respectively. Additionally, the following associations were observed: the intake of vitamin A (p=0.02), Copper (p=0.01), and Selenium (p=0.01) with the maternal Body Mass Index; the intake of vitamin A (0.04) and Selenium (p=0.02) with the birth weight; and between vitamin A (p=0.04) with the birth length. Conclusion The low intake of antioxidant nutrients by pregnant women is a reality, being associated to the maternal Body Mass Index and the birth weight and length of the newborn.

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Association between magnesium status, oxidative stress and inflammation in preeclampsia: A case–control study

Cited by 23 publications

References 22 publications

Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit

Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit

The Value of Legume Foods as a Dietary Source of Phytoprostanes and Phytofurans Is Dependent on Species, Variety, and Growing Conditions

Intake of antioxidants nutrients by pregnant womem: Associated factors

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