Association between macronutrients intake distribution and bone mineral density

Gao, Shihua; Qian, Xiaohong; Huang, Sicong; Deng, Wanxi; Li, Zhe; Hu, Yingyu

doi:10.1016/j.clnu.2022.05.019

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…This is consistent with our findings, where the researchers suggested that this negative correlation may be due to low calcium intake in children. This was supported by the report by Vatanparast et al, where the positive effect of dietary protein on bone mass was most significant in those who consumed sufficient calcium (>1000 mg/d) [ 37 ]. More studies have shown that long-term protein intake positively predicts whole-body BMC.…”

Section: Discussionsupporting

confidence: 55%

Opposing Effects of Nutritional Supply on Bone Health at Different Ages: Based on the National Health and Nutrition Examination Survey Database

Wei,

Zhang,

Yuan

et al. 2024

Nutrients

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(1) Background: Nutrients play an essential role in bone health, whether in achieving peak bone mineral density (BMD) or maintaining bone health. This study explores the relationship between nutrient supply and femoral bone health at different ages. (2) Methods: A total of 5603 participants meeting the inclusion and exclusion criteria were included in this study using the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2010, 2013 to 2014, and 2017 to 2018. Femoral bone mineral density and bone status were dependent variables, and dietary nutrient intake and nutrient intake status were independent variables. The relationship between dietary nutrient intake and bone mineral density was explored, and the importance of nutrients affecting bone status was analyzed through a neural network model. At the same time, we investigated the relationship between nutrient intake and bone status. (3) Results: The peak of age and femoral bone mineral density appeared at 20 years old in our study. After grouping by age, logistic regression analysis showed that before 20 years old, without adjusting other variables, high-fat diet was more likely to have normal bone mass than appropriate fat diet (OR: 4.173, 95%CI: 1.007–17.289). After adjusting for all demographic factors, niacin intake (OR: 1.062, 95%CI: 1.019–1.108) was beneficial for normal bone mass, while vitamin B6 intake (OR: 0.627, 95%CI: 0.408–0.965) was not. After 20 years old, after adjusting for carbohydrate, protein, vitamin B6, niacin, dietary fat, vitamin B2, and vitamin B12, vitamin B2 intake (OR: 1.153, 95%CI: 1.04–1.278) was beneficial for normal bone mass, while vitamin B6 intake (OR: 0.842, 95%CI: 0.726–0.976) was not. After adjusting for all confounding factors, vitamin B2 intake (OR: 1.288, 95%CI: 1.102–1.506) was beneficial for normal bone mass. In addition, we found that even if there was no statistical significance, the effects of high-fat diet on bone mass were different at different ages. (4) Conclusions: By conducting an in-depth analysis of the NHANES database, this study reveals that dietary factors exert divergent effects on bone health across different age groups, implying the necessity of implementing tailored dietary strategies to maintain optimal bone health at distinct life stages.

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Section: Discussionsupporting

confidence: 55%

Opposing Effects of Nutritional Supply on Bone Health at Different Ages: Based on the National Health and Nutrition Examination Survey Database

Wei,

Zhang,

Yuan

et al. 2024

Nutrients

View full text Add to dashboard Cite

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“…The result of our study also demonstrated that a high-fat diet was not considered to be a negative effect on BMD and the incidence of osteopenia or osteoporosis. A similar study also revealed fat intake appeared to be positively correlated with BMD [10].…”

Section: Discussionmentioning

confidence: 59%

“…Among the numerous risk factors for osteoporosis such as age, gender, body weight, estrogen, genetic factors, smoking, alcohol consumption, environmental and various metabolic diseases, low BMD is of utmost importance [9]. Bone mass begins to decrease with age after peak bone mass in adults, and bone health is also affected by dietary macronutrient intake [10,11]. Overwhelming evidence indicates that a high-fat diet that can affect bone mass, bone microarchitecture and impair bone metabolism (bone growth and bone loss) [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Association of High Fat Diet with Bone Mineral Density in the General American Population

Cheng

Jin

et al. 2022

Preprint

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Background The effect of a high-fat diet on bone mineral density is still controversial. The present study is to evaluate the relationship between a high-fat diet and bone mineral density in the American adults. Methods We performed a cross-sectional analysis of the US population aged 50 years or older based on data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. The primary outcome measure was the femur bone mineral density by dual energy x-ray absorptiometry (DXA) of osteoporosis or osteopenia. Multivariable logistic regression analysis was used to evaluate the effect of high-fat diet on the presence of osteopenia and osteoporosis. Results The prevalence of total femur, femoral neck, trochanter and intertrochanter osteopenia or osteoporosis respectively was 22.8%, 51.3%, 22.6% and 19.4% in men and 43.5%, 66.9%, 39% and 38% in women. Multivariable logistic regression analysis after adjustment for confounders showed that a high-fat diet was significantly associated with higher odds of total femur and trochanter osteopenia or osteoporosis in men and intertrochanteric osteopenia or osteoporosis in women. However, a high-fat diet was negatively associated with the occurrence of osteopenia or osteoporosis in male femoral neck and total femur and femoral neck in female. There were no significant associations between high-fat diet and osteopenia or osteoporosis in male intertrochanteric and in female trochanter. The subgroup analyses found that compared with normal fat intake, the highest fat intake levels were only significantly and negatively associated with femoral neck osteopenia or osteoporosis in men and total femur, trochanter and intertrochanteric in women. Conclusions The effects of a high-fat diet as a separate contribution to the incidence of osteopenia or osteoporosis were biphasic with both positive and negative effects that varied by femoral sites and were not gender-related. In addition, higher levels of dietary fat intake did not increase subject's the odds of osteopenia or osteoporosis.

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“…Another analysis also studied the NHANES database and extracted data from 4,447 subjects. The result showed that diets with a higher percentage of energy from protein were associated with higher T-scores ( 49 ). However, the two studies did not record the duration of HP diets.…”

Section: The Effect Of High-protein Diets On Bone Healthmentioning

confidence: 99%

The effects of popular diets on bone health in the past decade: a narrative review

Peng,

Zhong,

Huang

et al. 2024

Front. Endocrinol.

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Bone health encompasses not only bone mineral density but also bone architecture and mechanical properties that can impact bone strength. While specific dietary interventions have been proposed to treat various diseases such as obesity and diabetes, their effects on bone health remain unclear. The aim of this review is to examine literature published in the past decade, summarize the effects of currently popular diets on bone health, elucidate underlying mechanisms, and provide solutions to neutralize the side effects. The diets discussed in this review include a ketogenic diet (KD), a Mediterranean diet (MD), caloric restriction (CR), a high-protein diet (HP), and intermittent fasting (IF). Although detrimental effects on bone health have been noticed in the KD and CR diets, it is still controversial, while the MD and HP diets have shown protective effects, and the effects of IF diets are still uncertain. The mechanism of these effects and the attenuation methods have gained attention and have been discussed in recent years: the KD diet interrupts energy balance and calcium metabolism, which reduces bone quality. Ginsenoside-Rb2, metformin, and simvastatin have been shown to attenuate bone loss during KD. The CR diet influences energy imbalance, glucocorticoid levels, and adipose tissue, causing bone loss. Adequate vitamin D and calcium supplementation and exercise training can attenuate these effects. The olive oil in the MD may be an effective component that protects bone health. HP diets also have components that protect bone health, but their mechanism requires further investigation. In IF, animal studies have shown detrimental effects on bone health, while human studies have not. Therefore, the effects of diets on bone health vary accordingly.

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Association between macronutrients intake distribution and bone mineral density

Cited by 11 publications

References 36 publications

Opposing Effects of Nutritional Supply on Bone Health at Different Ages: Based on the National Health and Nutrition Examination Survey Database

Opposing Effects of Nutritional Supply on Bone Health at Different Ages: Based on the National Health and Nutrition Examination Survey Database

Association of High Fat Diet with Bone Mineral Density in the General American Population

The effects of popular diets on bone health in the past decade: a narrative review

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