Association between lower body temperature and increased tau pathology in cognitively normal older adults

Blessing, Esther; Parekh, Ankit; Betensky, Rebecca A.; Babb, James S.; Saba, Natalie; Debure, Ludovic; Varga, Andrew W.; Ayappa, Indu; Rapoport, David M.; Butler, Tracy; Leon, Mony J. de; Wısnıewskı, Thomas; Lopresti, Brian J.; Osorio, Ricardo S.

doi:10.1016/j.nbd.2022.105748

Cited by 4 publications

(1 citation statement)

References 126 publications

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“…In studies with a limited number of patients and controls, individuals with PSP showed a significant increase in nighttime core-body temperature than those with Parkinson’s disease, a synucleinopathy [ 48 ], and a higher nighttime blood pressure compared to controls [ 49 ]. Higher tau-PET tracer retention was correlated with lower daytime body temperature in a cognitively normal adult [ 50 ]. In summary, despite the limited number of studies and methodological constraints, there is confluent evidence of circadian dysfunction in tauopathies.…”

Section: Circadian Dysfunction In Tauopathiesmentioning

confidence: 99%

Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models

Son,

Neylan,

Grinberg

2024

Mol Neurodegeneration

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Tauopathies, a group of neurodegenerative diseases that includes Alzheimer’s disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The circadian rhythm, a recurring 24-hour cycle governing human biological activity, is regulated by the hypothalamic suprachiasmatic nucleus (SCN) and endogenous transcriptional-translational feedback loops. Surprisingly, little attention has been given to investigating tauopathy-driven neuropathology in the SCN and the repercussions of SCN and circadian gene dysfunction in the human brain affected by tauopathies. This review aims to provide an overview of the current literature on the vulnerability of the SCN in tauopathies in humans. Emphasis is placed on elucidating the neuronal and glial changes contributing to the widespread disruption of the molecular circadian clock. Furthermore, this review identifies areas of knowledge requiring further investigation.

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Section: Circadian Dysfunction In Tauopathiesmentioning

confidence: 99%

Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models

Son,

Neylan,

Grinberg

2024

Mol Neurodegeneration

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Night-to-night reliability and agreement of obstructive sleep apnea pathophysiologic mechanisms estimated with phenotyping using polysomnography in cognitively normal elderly participants

Tolbert

Schoenholz

Parekh

et al. 2023

Sleep

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Study Objectives Phenotyping using polysomnography (PUP) is an algorithmic method to quantify physiologic mechanisms underlying obstructive sleep apnea (OSA): loop gain (LG1), arousal threshold (ArTH), and upper airway collapsibility (Vpassive) and muscular compensation (Vcomp). The consecutive-night test-retest reliability and agreement of PUP-derived estimates is unknown. From a cohort of elderly (age ≥55 years), largely non-sleepy, community-dwelling volunteers who underwent in-lab polysomnography (PSG) on 2 consecutive nights, we determined the test-retest reliability and agreement of PUP-estimated physiologic factors. Methods Subjects who had an apnea-hypopnea index (AHI3A) of at least 15 events per hour on the first night were included. PUP analyses were performed on each of 2 PSGs from each subject. Physiologic factor estimates were derived from NREM sleep and compared across nights using intraclass correlation coefficients (ICC) for reliability and smallest real differences (SRD) for agreement. Results Two PSGs from each of 43 subjects (86 total) were analyzed. A first-night effect was evident with increased sleep time and stability and decreased OSA severity on the second night. LG1, ArTH, and Vpassive demonstrated good reliability (ICC >0.80). Vcomp had modest reliability (ICC = 0.67). For all physiologic factors, SRD values were approximately 20% or more of the observed ranges, suggesting limited agreement of longitudinal measurements for a given individual. Conclusion For NREM sleep in cognitively normal elderly individuals with OSA, PUP-estimated LG1, ArTH, and Vpassive demonstrated consistent relative ranking of individuals (good reliability) on short-term repeat measurement. For all physiologic factors, longitudinal measurements demonstrated substantial intraindividual variability across nights (limited agreement).

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Predictors of Conversion to Dementia in Patients With Mild Cognitive Impairment: The Role of Low Body Temperature

Alagiakrishnan

Dhami

2023

J Clin Med Res

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Association between lower body temperature and increased tau pathology in cognitively normal older adults

Cited by 4 publications

References 126 publications

Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models

Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models

Night-to-night reliability and agreement of obstructive sleep apnea pathophysiologic mechanisms estimated with phenotyping using polysomnography in cognitively normal elderly participants

Predictors of Conversion to Dementia in Patients With Mild Cognitive Impairment: The Role of Low Body Temperature

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