2017
DOI: 10.1161/hypertensionaha.116.08427
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Association Between Long-Term Blood Pressure Variability and 10-Year Progression in Arterial Stiffness

Abstract: Experimental studies conducted on animal and human endothelium suggested that higher systolic blood pressure (SBP) variability reduces bioavailability of nitric oxide and increases vascular smooth muscle cell proliferation. These vascular wall changes could stiffen the arterial wall. Using data from the Multi-Ethnic Study of Atherosclerosis, we investigated the association between long-term SBP variability and ten-year percent change in arterial stiffness among 1122 individuals (mean age 57 years, 46% Males at… Show more

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Cited by 78 publications
(72 citation statements)
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References 47 publications
(55 reference statements)
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“…Increased long-term BPV was found to be associated with stroke [4], cardiovascular events [2], arterial stiffnes s [5] and decreased GFR [3] and is therefore considered an independent risk factor for all-cause and cardiovascular mortality in non-hemodialysis patients. These remain, however, less well-investigated in hemodialysis patients.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Increased long-term BPV was found to be associated with stroke [4], cardiovascular events [2], arterial stiffnes s [5] and decreased GFR [3] and is therefore considered an independent risk factor for all-cause and cardiovascular mortality in non-hemodialysis patients. These remain, however, less well-investigated in hemodialysis patients.…”
Section: Discussionmentioning
confidence: 99%
“…The latter includes variations in BP that occur over more prolonged periods of time, such as days, weeks, months, seasons, and even years [1]. A growing number of studies performed in the general population have shown that BPV is a risk factor for target organ damage and mortality, independent of absolute BP level [2-5]. …”
Section: Introductionmentioning
confidence: 99%
“…These changes are influenced by hemodynamic forces 15,16 and extrinsic factors, such as hormones 17 and inflammatory mediators 18 , which may be related to sodium and glucose balance. 19 Arterial rigidity is modulated by means of a fine balance between production and degradation of elastin and collagen.…”
Section: Review Articlementioning
confidence: 99%
“…16 Chronically higher BP is linked to lower cognitive function in individuals <50 years of age. 79 In addition to BP levels, our previous study revealed that BP variability over multiple time points (i.e., long-term visit-to-visit BP variability) in young adulthood may be associated with lower cognitive function, and memory function in particular, at middle age.…”
Section: Introductionmentioning
confidence: 99%