Association Between Liver Function and Peak Oxygen Uptake in Heart Failure Patients: A Retrospective Observational Study

Hanada, Satoru; Kudo, Takeaki; Kanzaki, Tomohiro; Sakata, Koji; Iwakiri, Hironao

doi:10.2490/prm.20170014

Cited by 2 publications

(2 citation statements)

References 26 publications

(23 reference statements)

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“…Further research is needed on the pathophysiological principles involved. Our study raises objections to the hypothesis that liver function impairment and elevated TBIL lead to deterioration of AHF [37,38]. However, whether TBIL can independently represent liver function is still an unknown issue.…”

Section: Discussionmentioning

confidence: 83%

A Novel Nomogram for Predicting the Risk of Acute Heart Failure in ICU Patients with COPD

Wu,

Zhan,

Qiao

et al. 2023

Preprint

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Background This study developed a novel nomogram to predict the incidence of acute heart failure (AHF) in patients of chronic obstructive pulmonary disease (COPD) and evaluated the predictive value of the nomogram. Methods 3730 patients of chronic obstructive pulmonary disease from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database were analysed. The patients were randomly divided into two groups in a seven-to-three ratio to form a training cohort (n = 2611) and a validation cohort (n = 1119). Least absolute shrinkage and selection operator (LASSO) regression analyses were used to identify associated risk variables. A nomogram was established to predict the rate of acute heart failure in patients of chronic obstructive pulmonary disease. The new model was assessed in terms of the concordance index (C-index), the area under the curve (AUC) of receiver operating characteristic (ROC) analysis, calibration curve, and decision curve analysis (DCA). Results Least absolute shrinkage and selection operator regression analysis identified ten potential predictors of acute heart failure. Multivariate logistic regression analysis was used to evaluate the effects of these predictors and create a final model. The concordance index values were 0.820. The areas under the curves for the training and validation sets were 0.8195 and 0.8035, respectively. Conclusion The age, body mass index (BMI), urine output, carbon dioxide partial pressure (pCO2), bicarbonate, partial thromboplastin time (PTT), total Bilirubin (TBIL), urea, chloride and ventilation status were identified as predictors. Our nomogram is a reliable convenient approach for predicting acute heart failure in patients with chronic obstructive pulmonary disease.

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Section: Discussionmentioning

confidence: 83%

A Novel Nomogram for Predicting the Risk of Acute Heart Failure in ICU Patients with COPD

Wu,

Zhan,

Qiao

et al. 2023

Preprint

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“…Normal liver function is crucial for the circulatory system. Liver failure and circulatory dysfunction are strongly related to one another [29,30]. Alkaline phosphatase (ALP) has been reported to be a biomarker for liver congestion in patients with heart failure [31].…”

Section: Discussionmentioning

confidence: 99%

Hematological and demographic profile of Pakistani children with isolated ventricular septal defects (VSDs)

Sarwar

Shabana

Ehsan

et al. 2020

Egypt J Med Hum Genet

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Background Cardiac morphogenesis is a dynamic and complex process that involves a complex interaction of many genetic and environmental factors. Ventricular septal defects (VSDs) are the commonest congenital heart defects (CHDs), accounting for ~ 40% of all cardiac malformations. In Pakistan, the prevalence of VSD is increasing (4–6 in 1000 live births). In the current study, we aimed to determine the pattern of different hematological parameters and various risk factors in VSDs in local pediatric patients. We recruited the clinically diagnosed VSD children (n = 125) from various hospitals. The diagnosis was made based on echocardiography, size, number, and exact location of the defect. Hematological parameters, chemical pathological assays, and liver function analysis were performed. The blood group distribution and various risk factors were also assessed. The statistical analysis was done using the SPSS (IBM statistics version 22) software. Results The results showed that for RBCs, 20% of patients in category of 0 to 3 months are above normal range; for WBCs, 33.3% of patients are above normal range in category of 4–5 years and 12–14 years. For hemoglobin, highest percentage of patients was observed below normal range; 30% of patients in category of 0 to 3 months, 40% of patients in category 4–9 months, 35.2% of patients in category of 10 months–3 years, and 33.3% of patients in category of 12–14 years were below normal range. For platelet count, 5.66% patients were below normal range and 16.9% were above normal range. For prothrombin time (PT) and activated partial thromboplastin time (APTT) more than 90% patients were in normal range value. Elevated ALP level and significantly lower albumin levels were observed. In age range of 13–14 years, 50% patients were below range for both calcium and serum creatinine. The prevalence of cousin marriages was 62.3%, about 60% mothers used antibiotics during pregnancy, B + ve and O + ve had the highest frequencies, and most of the patients were seen in age group of 2–35 months. Conclusion All tested parameters show divergence from normal values their predictive capabilities of VSDs. To the best of our knowledge, the present study is the first to report data on hematological parameters and demographic risk factor associated with VSDs, in the Pakistani children. This data may have implication on the characterization and diagnosis of VSDs as well as on the assessment of related risk factors.

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Association Between Liver Function and Peak Oxygen Uptake in Heart Failure Patients: A Retrospective Observational Study

Cited by 2 publications

References 26 publications

A Novel Nomogram for Predicting the Risk of Acute Heart Failure in ICU Patients with COPD

A Novel Nomogram for Predicting the Risk of Acute Heart Failure in ICU Patients with COPD

Hematological and demographic profile of Pakistani children with isolated ventricular septal defects (VSDs)

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