Association between liver cirrhosis and peri-implant diseases: a case-control study on implant- and patient-related risk factors

Background Strong evidence suggests the infectious nature of peri‐implant diseases occurring in susceptible hosts. Epidemiological reports, though, indicate that peri‐implantitis is a site‐specific entity. Hence, the significance of local factors that may predispose/precipitate plaque accumulation and the impact of systemic drivers that alter the immune response are relevant in the prevention and management of peri‐implant disorders. Purpose The purpose of the present review is to shed light on the significance of local and systemic factors on peri‐implant diseases, making special emphasis on the associations with peri‐implantitis. Methods The biologic plausibility and supporting evidence aiming at providing a concluding remark were explored in the recent scientific literature for local predisposing/precipitating factors and systemic drivers related to peri‐implant diseases. Results Local predisposing factors such as soft tissue characteristics, implant position and prosthetic design proved being strongly associated with the occurrence of peri‐implant diseases. Hard tissue characteristics, however, failed to demonstrate having a direct association with peri‐implant diseases. Robust data points toward the strong link between residual sub‐mucosal cement and peri‐implant diseases, while limited data suggests the impact of residual sub‐mucosal floss and peri‐implantitis. Systemic drivers/habits such as hyperglycemia and smoking showed a strong negative impact on peri‐implantitis. However, there is insufficient evidence to claim for any link between metabolic syndrome, atherosclerotic cardiovascular disease, and obesity and peri‐implant diseases. Conclusion Local predisposing/precipitating factors and systemic drivers may increase the risk of peri‐implant diseases. Therefore, comprehensive anamnesis of the patients, educational/motivational programs and exhaustive prosthetically‐driven treatment planning must be fostered aiming at reducing the rate of biological complications in implant dentistry.

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“…150,151 • Liver cirrhosis. 152 • Osteoporosis/bone metabolic disorders. 98 • Radiation/radiotherapy (for head and neck cancer).…”

Section: Other Potentially Systemic Driversmentioning

confidence: 99%

Impact of local predisposing/precipitating factors and systemic drivers on peri‐implant diseases

Monje

Kan

Borgnakke

2022

Clin Implant Dent Rel Res

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“…Cirrhosis, the severe liver damage caused by cigarette smoking, increases a person's vulnerability to several kinds of infections throughout the body ( 54 ). Innate and adaptive immune responses are disrupted, the complement system malfunctions and the number of white blood cells drops as a consequence of cirrhosis ( 54 ). It was shown that cirrhotic persons were 2.5 times more likely to have peri-implant infections compared to non-cirrhotic people.…”

Section: Other Complications Associated With Smoking and Nafldmentioning

confidence: 99%

“…It was shown that cirrhotic persons were 2.5 times more likely to have peri-implant infections compared to non-cirrhotic people. Smokers were also more vulnerable to and more likely to develop serious infections ( 54 ).…”

Section: Other Complications Associated With Smoking and Nafldmentioning

confidence: 99%

Association between smoking and non-alcoholic fatty liver disease in Southeast Asia

Mumtaz

Hameed²,

Sangah

et al. 2022

Front. Public Health

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An estimated 8 million people die each year from tobacco smoking, with an increasing frequency recently being observed in Southeast Asian countries, which is a preventable risk factor for mortality. NAFLD, fibrosis, advancement of hepatocellular carcinoma, and prognosis for those with severe liver disease are all negatively influenced. NAFLD and cigarette usage seem to be a direct link. Oxidative stress and oncogenic signals have been implicated in cancer development in animal models and human clinical trials. The elevated risk of cardiovascular disease and malignancies in those with steatohepatitis and those who have had liver transplants is exacerbated by smoking. We found that smoking cessation may increase treatment response and fibrosis regression rates, decrease hepatocellular carcinoma incidence, and improve liver transplant outcomes. In the last segment, we'll look at electronic cigarettes, a hot subject in public health right now, as well as additional repercussions of smoking.

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Assessment of risk factors and causes of inflammatory changes in the oral mucosa and bone tissue of the jaws surrounding dental implants

Ebrakhim,

Moiseev,

Strelnikov

et al. 2024

Rus. J. Oper. Surg. Clin. Anat.

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Association between liver cirrhosis and peri-implant diseases: a case-control study on implant- and patient-related risk factors

Cited by 3 publications

References 50 publications

Impact of local predisposing/precipitating factors and systemic drivers on peri‐implant diseases

Impact of local predisposing/precipitating factors and systemic drivers on peri‐implant diseases

Association between smoking and non-alcoholic fatty liver disease in Southeast Asia

Assessment of risk factors and causes of inflammatory changes in the oral mucosa and bone tissue of the jaws surrounding dental implants

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