Association between LINC-PINT and LINC00599 gene polymorphism and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China

Sun, Menghu; Cao, Yong; Wang, Tiantian; Liu, Tingting; An, Feimeng; Wu, Huiqiang; Wang, Jianzhong

doi:10.1016/j.steroids.2021.108886

Cited by 5 publications

(8 citation statements)

References 32 publications

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“…This indicates the effects of the rs1333049 C allele, rs4977574 G allele, and rs10757274 G allele on lipid profiles predominantly in the TG levels. Since TG levels were closely related to the pathogenesis of CAD (30)(31)(32)(33)(34)71), these three alleles of the three variants may be a potential marker for CAD.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, we attempted to utilize the light of evidence-based medicine by a meta-analysis to examine the differences and to identify the sources of heterogeneity across these independent studies to reveal a common truth (whether variants of rs1333049, rs4977574, rs10757274, rs10757278, and rs10811661 in 9p21.3 are statistically impacted or with a trend to influence lipid levels). Moreover, the specific reason to select these five variants rather than other variants loci in 9p21.3, such as LINC-PINT ( 30 ), LINC00599 ( 30 ), or rs1537373 ( 31 ), is due to only these five variants with sufficient data to execute meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

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Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile

Wei

Liu

et al. 2022

Front. Cardiovasc. Med.

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BackgroundSeveral 9p21.3 variants, such as rs1333049, rs4977574, rs10757274, rs10757278, and rs10811661, identified from recent genome-wide association studies (GWASs) are reported to be associated with coronary artery disease (CAD) susceptibility but independent of dyslipidemia. This study investigated whether these 9p21.3 variants influenced lipid profiles.Methods and resultsBy searching the PubMed and Cochrane databases, 101,099 individuals were included in the analysis. The consistent finding for the rs1333049 C allele on lipid profiles increased the triglyceride (TG) levels. Moreover, the rs4977574 G allele and the rs10757274 G allele, respectively, increased low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels. However, the rs10811661 C allele largely reduced LDL-C levels. Subgroup analyses indicated that the effects of the rs1333049 C allele, rs4977574 G allele, and rs10757274 G allele on lipid profiles were stronger in Whites compared with Asians. In contrast, the effect of the rs10811661 C allele on lipid profiles was stronger in Asians compared with Whites.ConclusionThe rs1333049 C allele, rs4977574 G allele, and rs10757274 G allele of lncRNA, and the rs10811661 G allele of CDKN2A/2B had a significant influence on lipid levels, which may help the understanding of the underlying mechanisms between 9p21.3 variants and CAD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile

Wei

Liu

et al. 2022

Front. Cardiovasc. Med.

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“…Furthermore, as noted above, LINC‐PINT rs10234094‐C was associated with complications in AD patients among APOEε4‐negative individuals (Reddy et al, 2021). Moreover, the relationship LINC‐PINT SNPs with steroid‐induced osteonecrosis of the femoral head (ONFH) in Han Chinese individuals showed, two SNPs rs157916 and rs16873842 showing association with low risk, while rs7781295 showed a protective effect for steroid‐induced ONFH (Sun et al, 2021). However, functional impact of these SNPs of LINC‐PINT on various diseases has barely studied.…”

Section: Polymorphisms In Linc‐pintmentioning

confidence: 99%

PINTology: A short history of the lncRNA LINC‐PINT in different diseases

et al. 2022

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LINC-PINT is a p53-induced long intergenic noncoding transcript that plays a crucial role in many diseases, especially cancer. This long noncoding RNA (lncRNA) gene produces in total 102 (LNCipedia) alternatively spliced variants (LINC-PINT:1 to LINC-PINT:102). The functions of known variants include RNA transcripts, host transcripts for circular RNA (circRNA) generation and as sources for the translation of short peptides. In most human tumors, LINC-PINT is down-regulated where it serves as a tumor suppressor. However, the diversity of its functions in other maladies signifies its general clinical importance. Current LINC-PINT molecular functions include RNA-protein interactions, miRNA sponging and epigenetic modulation with these mechanisms operating in different cellular contexts to exert effects on biological processes ranging from DNA damage responses, cell cycle and growth arrest, senescence, cell migration and invasion, and apoptosis. Genetic polymorphisms in LINC-PINT have also been functionally associated with cancer and other pathologies including the autoimmune diseases pemphigus foliaceus and arthritis. Hence, LINC-PINT shows great potential as a clinical biomarker, especially for the diagnosis and prognosis of cancer. In this review, we explore the current knowledge highlighting the distinctive molecular functions of LINC-PINT in specific cancers and other disease states.Ihtisham Bukhari and Muhammad Riaz Khan contributed equally to this study.

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“…LINC-PINT also regulates transforming growth factor beta (TGF-β) and Wnt/β-catenin pathways. SNP of this gene are related to several diseases, as cancer and increased susceptibility to steroid-induced osteonecrosis [ 35 ] ( Table 1 ).…”

Section: Pathogenesismentioning

confidence: 99%

“… Gene Risk Ref. ATP-binding cassette subfamily B member 1 (ABCB1) Reduced [ 24 ] Cytochrome P450 Reduced [ 25 ] IL1B Increased or reduced [ 26 ] Metalloproteinase 2, 8, and 10 Increased [ 27 , 28 ] Metalloproteinase 9 Reduced [ 32 ] RETN Increased [ 29 ] APOA5 Increased [ 30 ] APOE Increased [ 31 ] TIMP4 Reduced [ 33 ] PAI-1 Increased [ 34 ] LncRNA LINC-PINT Increased [ 35 ] VEGF Increased [ 13 ] NO Increased [ 13 ] …”

Section: Pathogenesismentioning

confidence: 99%