Association between lifetime alcohol consumption and prostate cancer risk: A case-control study in Montreal, Canada

Demoury, Claire; Karakiewicz, Pierre I.; Parent, Marie‐Élise

doi:10.1016/j.canep.2016.09.004

Cited by 26 publications

(27 citation statements)

References 23 publications

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“…This nding of ours is compatible with a prospective study in the United States, which also observed no association between consumption of alcohol and prostate cancer [38]. Similarly, Demoury and colleagues also showed no signi cant association between lifetime in-take of alcohol and prostate cancer in Canadian men [39]. Even-though there is yet unresolved biological justi cation between alcohol consumption and prostate cancer, reports of dose-dependent risk abound.…”

Section: Resultssupporting

confidence: 89%

Putative Risk Factors of Prostate Cancer in Unscreened Ghanaian Men

Gyamfi¹,

Anto²,

Acheampong³

et al. 2020

Preprint

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African countries with weak health systems and infrastructure are at risk of high incidence and mortality of prostate cancer. The absence of specific causative agents for prostate cancer calls for early detection strategies and the identification of susceptible factors. We undertook a community-based prostate-specific antigen screening of Ghanaian men to ascertain the association between putative risk factors and prostate cancer. Using an adjusted PSA cut-off we found a prostate cancer prevalence of 12.5% with most men diagnosed between 62–77 years (Mean; 69.50 ± 8.46). We found no statitsically significant association between putative risk factors such as obesity, hypertension, intake of alcohol, and smoking with prostate cancer. However, we observed a significant association between age and occupation, and prostate cancer. Prostate cancer is a growing challenge in Ghanaian men. Detection with PSA offers diagnostic significance and may help in reducing the burden in men. Differences in genetic and environmental differences between populations call for a population-specific assessment of risk factors.

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Section: Resultssupporting

confidence: 89%

Putative Risk Factors of Prostate Cancer in Unscreened Ghanaian Men

Gyamfi¹,

Anto²,

Acheampong³

et al. 2020

Preprint

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“… 10 Regarding types of alcohol consumption, in a large cohort of 3,927 subjects, Demoury et al showed that beer was associated with a 37% increase risk of high-grade PCa. 30 In the present study, we found that wine is not associated with an increased risk of PCa as other alcohol or beer consumption is. This could be based on several factors that make wine less harmful than other types of alcohols.…”

Section: Discussionsupporting

confidence: 39%

The impact of moderate wine consumption on the risk of developing prostate cancer

Vartolomei¹,

Kimura²,

Ferro³

et al. 2018

CLEP

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ObjectiveTo investigate the impact of moderate wine consumption on the risk of prostate cancer (PCa). We focused on the differential effect of moderate consumption of red versus white wine.DesignThis study was a meta-analysis that includes data from case–control and cohort studies.Materials and methodsA systematic search of Web of Science, Medline/PubMed, and Cochrane library was performed on December 1, 2017. Studies were deemed eligible if they assessed the risk of PCa due to red, white, or any wine using multivariable logistic regression analysis. We performed a formal meta-analysis for the risk of PCa according to moderate wine and wine type consumption (white or red). Heterogeneity between studies was assessed using Cochrane’s Q test and I2 statistics. Publication bias was assessed using Egger’s regression test.ResultsA total of 930 abstracts and titles were initially identified. After removal of duplicates, reviews, and conference abstracts, 83 full-text original articles were screened. Seventeen studies (611,169 subjects) were included for final evaluation and fulfilled the inclusion criteria. In the case of moderate wine consumption: the pooled risk ratio (RR) for the risk of PCa was 0.98 (95% CI 0.92–1.05, p=0.57) in the multivariable analysis. Moderate white wine consumption increased the risk of PCa with a pooled RR of 1.26 (95% CI 1.10–1.43, p=0.001) in the multi-variable analysis. Meanwhile, moderate red wine consumption had a protective role reducing the risk by 12% (RR 0.88, 95% CI 0.78–0.999, p=0.047) in the multivariable analysis that comprised 222,447 subjects.ConclusionsIn this meta-analysis, moderate wine consumption did not impact the risk of PCa. Interestingly, regarding the type of wine, moderate consumption of white wine increased the risk of PCa, whereas moderate consumption of red wine had a protective effect. Further analyses are needed to assess the differential molecular effect of white and red wine conferring their impact on PCa risk.

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“…Moreover, exposures in specific periods may be hypothesized to affect tumor aggressiveness. Aggressive and non-aggressive PCa appear to have different sets of anthropometric ( 31 ), lifestyle ( 32 ) and occupational ( 33 ) risk factors, supporting the notion that their etiology might be under distinct influences. Recent observations also indicate that grade is established early in prostate tumor pathogenesis ( 34 ).…”

Section: Introductionmentioning

confidence: 86%

Disadvantageous Socioeconomic Position at Specific Life Periods May Contribute to Prostate Cancer Risk and Aggressiveness

et al. 2018

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Background: Previous studies on socioeconomic position (SEP) and risk of prostate cancer (PCa) have produced contradictory results. Most measured SEP only once during the individuals' life span. The aim of the study was to identify life course models that describe best the relationship between SEP measured during childhood/adolescence, early- and late-adulthood, and risk of PCa overall as well as according to tumor aggressiveness at diagnosis.Methods: We used data from a population-based case-control study of PCa conducted in the predominantly French-speaking population in Montreal, Canada. Cases (n = 1,930) with new, histologically-confirmed PCa were ascertained across hospitals deserving the French-speaking population in 2005–2009. Controls (n = 1,991), selected from Quebec's list of French-speaking electors, were frequency-matched to cases (±5 years). In-person interviews collected information on socio-demographic and lifestyle characteristics, and a complete occupational history. Measures of SEP during childhood/adolescence included parents' ownership of a car and father's longest occupation, while the subject's first and longest occupations were used to indicate early- and late-adulthood SEP, respectively. We used the Bayesian relevant life course exposure model to investigate the relationship between lifelong SEP and PCa risk.Results: Cumulative exposure to disadvantageous SEP was associated with about a 50% increase in odds of developing PCa. Late-adulthood SEP was identified as a sensitive period for aggressive PCa. Childhood/adolescence SEP based on parents' ownership of a car was associated with non-aggressive PCa. Associations were independent from PCa screening.Conclusion: Disadvantageous SEP over the life course was associated with higher PCa incidence, with consistent evidence of sensitive time periods for cancer aggressiveness. The mechanisms through which disadvantageous SEP relates to PCa risk need to be further elucidated.

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Association between lifetime alcohol consumption and prostate cancer risk: A case-control study in Montreal, Canada

Abstract: Findings add to the accumulating evidence that high alcohol consumption increases the risk of high-grade PCa. This association largely reflected beer intake in our population, and was strengthened when taking into account PCa screening history.

Cited by 26 publications

References 23 publications

Putative Risk Factors of Prostate Cancer in Unscreened Ghanaian Men

Putative Risk Factors of Prostate Cancer in Unscreened Ghanaian Men

The impact of moderate wine consumption on the risk of developing prostate cancer

Disadvantageous Socioeconomic Position at Specific Life Periods May Contribute to Prostate Cancer Risk and Aggressiveness

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