Association between levels of serum perfluorooctane sulfate and carotid artery intima–media thickness in adolescents and young adults

Lin, Chien Yu; Lin, Lian Yu; Wen, Ting Wen; Lien, Guang Wen; Chien, Kuo Liong; Hsu, Sandy Huey-Jen; Liao, Chien Chang; Sung, Fung Chang; Chen, Pau‐Chung; Su, Ta Chen

doi:10.1016/j.ijcard.2013.04.042

Cited by 79 publications

(76 citation statements)

References 68 publications

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“…The reliability of the CIMT measurements for the bilateral CCA (mean of the right and left CCA) was excellent. The intraobserver coefficient of correlation for the CIMT measurements was 98.8% for the right CCA and 98.5% for the left CCA 20) .…”

Section: Assessment Of the Imt Of The Carotid Arteriesmentioning

confidence: 86%

“…From 1992 to 2000, a nationwide mass urine screening for renal health was conducted among school children 6 to 18 years of age in Taiwan 8,[18][19][20] . The anthropometric status and blood pressure were also measured in all children diagnosed with positive proteinuria or glucosuria twice during the screening examinations (N = 103,756).…”

Section: Subjectsmentioning

confidence: 99%

“…The protocol for the carotid atherosclerosis measurements, including the CIMT and number of carotid atherosclerotic plaques, has been well documented 18,20,23,24) . An experienced technician measured the CIMT of the extracranial carotid arteries using high-resolution B-mode ultrasonography (GE Vivid ultrasound system, Horten, Norway) equipped with a 3.5-to 10-MHz real-time B-mode scanner.…”

Section: Assessment Of the Imt Of The Carotid Arteriesmentioning

confidence: 99%

“…Fig. 1 shows a flow chart of the present study starting from the urinary screening program to participant recruitment 20) . We sent invitation letters to the parents of eligible students in the Taipei area.…”

Section: Introductionmentioning

confidence: 99%

“…Among the 707 subjects with childhood EBP, 303 completed the follow-up health examinations, for a response rate of 42.9%. The detailed information is available in recent reports 18,20) . Among the 59,855 subjects with a normal BP in childhood with an address, 17,448 lived in Taipei.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

An Overweight or Obese Status in Childhood Predicts Subclinical Atherosclerosis and Prehypertension/Hypertension in Young Adults

Liao

Chien

et al. 2014

JAT

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Section: Assessment Of the Imt Of The Carotid Arteriesmentioning

confidence: 86%

Section: Subjectsmentioning

confidence: 99%

Section: Assessment Of the Imt Of The Carotid Arteriesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An Overweight or Obese Status in Childhood Predicts Subclinical Atherosclerosis and Prehypertension/Hypertension in Young Adults

Liao

Chien

et al. 2014

JAT

Self Cite

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Long Chain Per/Polyfluoroalkyl Acids (C8 and Above)

Dourson,

Kougias,

Anderson

et al. 2024

Patty's Toxicology

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This chapter is about a series of per‐ and polyfluoroalkyl substances (PFAS) that can also be described as “long‐chain” perfluoroalkyl acids (PFAAs). The overall structure of PFAAs is a lengthy carbon chain with fluorine atoms substituting for hydrogen atoms and either a carboxylic or sulfonate head group. PFAAs are unusually chemically stable, water and oil resistant, and useful for many industrial applications, such as in the formation of polymers. In biological systems, these chemicals are generally well‐absorbed, resistant to metabolism, but also have the unusual property of widely different elimination kinetics among and within mammalian species. The range of estimated elimination half‐lives in humans for the perfluorooctanoic acid (PFOA), for example, is quite large ranging from one‐half to as much as 14 years, although a recent estimate from an international collaboration places this value closer to 1 year. The available literature on PFAAs is voluminous. This chapter will not attempt to review all this literature. Rather human studies will be emphasized, but since these studies nearly always suggest associations between PFAA exposure and health outcomes, this will be followed by studies in experimental animals that give insights into the human evidence. Afterward, a summary of attempts to estimate potential human risk by various international agencies will be described. What will become obvious, however, is that the overall uncertainty in the database of these chemicals has led to widely divergent risk assessment positions that need to be resolved. Risk management decisions on this class of chemistries are seen to be premature without such scientific resolution.

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Protection of Taurine Against PFOS-Induced Neurotoxicity in PC12 Cells

Liu

et al. 2017

Advances in Experimental Medicine and Biology

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As a new member of persistent organic pollutants, the potent neurotoxicity of perfluorooctane sulfonates (PFOS) found in epidemiological studies and laboratory research has drawn increasing attention around the world. Previous studies showed that apoptosis driven by oxidative stress and autophagy were both observed in PFOS-induced toxicity. Taurine has been demonstrated to exert potent protections against oxidative stress as an efficient antioxidant. Whether taurine could protect against the PFOS neurotoxicity is not known. In the present study, PC12 cells were treated with several concentrations of PFOS (31.25, 250 μM) for 24 h. 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay was applied to assess the cell viability. DCFH-DA detector was used to explore the production of ROS. Caspase 3 activity was used to reflect the possible apoptosis pathway. The lyso-tracker red dying was invited to evaluate the autophagy. Our data showed that taurine could significantly reverse the decreased viability and the increased ROS production in PC12 cells treated with PFOS. Moreover, the increased autophagy and apoptosis elicited by PFOS in PC12 cells could also be attenuated by taurine. Collectively, our results indicate that taurine may be an effective antioxidant in fighting against PFOS cytotoxicity and therefore could potentially serve as a preventative and therapeutic agent for environmental pollution-related toxicities.

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Association between levels of serum perfluorooctane sulfate and carotid artery intima–media thickness in adolescents and young adults

Cited by 79 publications

References 68 publications

An Overweight or Obese Status in Childhood Predicts Subclinical Atherosclerosis and Prehypertension/Hypertension in Young Adults

An Overweight or Obese Status in Childhood Predicts Subclinical Atherosclerosis and Prehypertension/Hypertension in Young Adults

Long Chain Per/Polyfluoroalkyl Acids (C8 and Above)

Protection of Taurine Against PFOS-Induced Neurotoxicity in PC12 Cells

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