Association between leukocyte telomere length and sex by quantile regression analysis

Gutierrez-Rodrigues, Fernanda; Alves-Paiva, Raquel M.; Scatena, Natália Ferreira; Martinez, Edson Zangiacomi; Scheucher, Priscila Santos; Calado, Rodrigo T.

doi:10.1016/j.htct.2020.12.005

Cited by 5 publications

(6 citation statements)

References 16 publications

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“…Considering that the telomere attrition rate significantly differs between the two genders with respect to age (Barrett and Richardson 2011; Gutierrez-Rodrigues et al, 2021), it seems that in studies such as the present study, gender of participants is an important confounding factor. Therefore, the present study was performed on male participants to avoid gender-confounding effects.…”

Section: Methodsmentioning

confidence: 79%

Morphine may have a role in telomere shortening

Darvishi

Saadat

2021

Psychiatric Genetics

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Morphine/heroin may increase oxidative stress in drug-dependent persons. The imbalance between oxidative stress and antioxidant defense mechanisms can accelerate the shortening of telomere length. This article reports two sets of data; comparison of relative telomere length between heroin-dependent patients and healthy control group, as well as, investigation of the effect of morphine on the relative telomere length of human SH-SY5Y cells treated by morphine. Study participants were composed of 163 heroin-dependent patients and 166 unrelated healthy controls. SH-SY5Y cells were treated with (5 μM) morphine hydrochloride and incubated for 40 and 60 days. The relative telomere length was calculated as the T/S (telomere/single-copy gene) ratio using 36B4 as a reference for each sample, using quantitative real-time PCR. The mean (± SE) value of relative telomere length was 4.81 ± 0.21 and 6.38 ± 0.23 in leukocytes of heroin-dependent and control groups, respectively. The telomere length was significantly decreased in heroin-dependent participants (t = 4.97; df = 327; P < 0.0001). The relative telomere length in cells treated with morphine for 60 days was 4.50 ± 0.14 and in untreated cells was 5.75 ± 0.08. The difference was highly significant (t = 7.68; df = 4; P = 0.002). Our present findings indicate that morphine and dependency on heroin are significantly associated with shorter telomeres. The present findings may help to explain some of the adverse effects of drug dependency on health such as accelerating biologic processes related to aging.

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Section: Methodsmentioning

confidence: 79%

Morphine may have a role in telomere shortening

Darvishi

Saadat

2021

Psychiatric Genetics

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“…The differences in methodology (Flow-FISH or qPCR) or statistical analysis (quantile or linear regression) may explain the controversial results of the median LTL between sexes. Therefore, further research needs to be done to better understand this phenomenon [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Association between leukocyte telomere length and COVID-19 severity

Mahmoodpoor

Sanaie

Eskandari

et al. 2023

Egypt J Med Hum Genet

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Background Inter-individual variations in the clinical manifestations of SARS-CoV-2 infection are among the challenging features of COVID-19. The known role of telomeres in cell proliferation and immune competency highlights their possible function in infectious diseases. Variability in telomere length is an invaluable parameter in the heterogeneity of the clinical presentation of diseases. Result In this study, our aim was to investigate the possible association between leukocyte telomere length (LTL) and COVID-19 severity. LTL was measured in 100 patients with moderate and severe forms of COVID-19 using the quantitative PCR (q-PCR) method. Statistical analysis confirmed a strong inverse correlation between relative LTL and COVID-19 severity. Conclusions These findings suggest that LTL can be a useful parameter for predicting disease severity in patients, as individuals with short telomeres may have a higher risk of developing severe COVID-19.

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“…Recent studies have demonstrated no sex difference in adult telomere length in vertebrates 71 , thus including female mice in our study is unlikely to change the interpretation of the mouse results. Yet, studies in humans have revealed differences in telomere length between sexes, depending on the age examined and the methodology used 72 – 74 . Thus, subsequent studies should consider telomere differences between sexes, especially given the rise in the number of female astronauts participating in space missions, and other reported differences in additional metrics between the sexes in other spaceflight studies 75 , 76 .…”

Section: Discussionmentioning

confidence: 99%

Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length

Tichy,

Lee,

et al. 2023

npj Microgravity

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Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity. Spaceflight elongates human telomeres in peripheral blood, which shorten upon return to Earth and approach baseline levels during postflight recovery. Astronauts also encounter muscle atrophy, losing up to 20% loss of muscle mass on spaceflights. Telomere length changes in muscle cells of astronauts remain unexplored. This study investigates telomere alterations in grounded mice experiencing radiation exposure and muscle atrophy, via a hindlimb unloading spaceflight mimicking model. We find telomere lengthening is present in muscle stem cells and in myofiber nuclei, but not in muscle-resident endothelial cells. We further assessed telomere length in the model following hindlimb unloading recovery. We find that telomere length failed to return to baseline values. Our results suggest a role for telomeres in muscle acclimatization, which is relevant for the well-being of astronauts in space, and upon their return to Earth.

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Association between leukocyte telomere length and sex by quantile regression analysis

Cited by 5 publications

References 16 publications

Morphine may have a role in telomere shortening

Morphine may have a role in telomere shortening

Association between leukocyte telomere length and COVID-19 severity

Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length

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