Association between lens opacities and mortality in the Priverno Eye Study

Nucci, Carlo Alberto; Cedrone, C; Culasso, Franco; Cesareo, Massimo; Regine, Federico; Cerulli, L

doi:10.1007/s00417-003-0837-z

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…This may be contributed to by lack of reliable capture of date of death data within the EMR as it is not automatically retrieved from the hospital administration system unless a record number is typed into the EMR and hence is not reliably recorded within the dataset we are able to extract. We report a 0.45% death rate in 7 years compared with 5.1%–21.4% for patients >45–55 years in other studies 22 23. In addition, patients may have presented with RD to other units, but this factor was mitigated by searching the database of our closest neighbouring units.…”

Section: Discussionmentioning

confidence: 59%

Risk factors for retinal detachment following cataract surgery: the impact of posterior capsular rupture

et al. 2016

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Section: Discussionmentioning

confidence: 59%

Risk factors for retinal detachment following cataract surgery: the impact of posterior capsular rupture

et al. 2016

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“…Among the 10 studies, 2 were conducted in Asia [22]–[23], 2 were in Australia [21], [24], 2 were in Europe [25]–[26] and the remaining 4 were in the United States [1]–[2], [27]–[28]. The 10 cohort studies comprised a total of 39,659 individuals at baseline.…”

Section: Resultsmentioning

confidence: 99%

Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis

Song

Sun

et al. 2014

PLoS ONE

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PurposeChanges in lens may reflect the status of systemic health of human beings but the supporting evidences are not well summarized yet. We aimed to determine the relationship of age-related cataract, cataract surgery and long-term mortality by pooling the results of published population-based studies.MethodsWe searched PubMed and Embase from their inception till March, 2014 for population-based studies reporting the associations of any subtypes of age-related cataract, cataract surgery with all-cause mortality. We pooled the effect estimates (hazards ratios [HRs]) under a random effects model.ResultsTotally, we identified 10 unique population-based studies including 39,659 individuals at baseline reporting the associations of any subtypes of cataract with all-cause mortality from 6 countries. The presence of any cataract including cataract surgery was significantly associated with a higher risk of death (pooled HR: 1.43, 95% CI, 1.21, 2.02; P<0.001; I2 = 64.2%). In the meta-analysis of 9 study findings, adults with nuclear cataract were at higher risks of mortality (pooled HR: 1.55, 95% CI, 1.17, 2.05; P = 0.002; I2 = 89.2%). In the meta-analysis of 8 study findings, cortical cataract was associated with higher risks of mortality (pooled HR: 1.26, 95% CI, 1.12, 1.42; P<0.001, I2 = 29.7%). In the meta-analysis of 6 study findings, PSC cataract was associated with higher risks of mortality (pooled HR: 1.37, 95% CI, 1.04, 1.80; P = 0.03; I2 = 67.3%). The association between cataract surgery and mortality was marginally non-significant by pooling 8 study findings (pooled HR: 1.27, 95% CI, 0.97, 1.66; P = 0.08; I2 = 76.6%).ConclusionsAll subtypes of age-related cataract were associated with an increased mortality with nuclear cataract having the strongest association among the 3 cataract subtypes. However, cataract surgery was not significantly related to mortality. These findings indicated that changes in lens may serve as markers for ageing and systemic health in general population.

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“…In our study, Figure c shows a clear correlation between visual acuity and long‐term mortality, and this persisted after adjustment for age, sex, diabetes mellitus and hypertension (Table ). There are several other long‐term epidemiology studies in different populations that explore the relationship between vision and mortality . They show visual impairment (best‐corrected visual acuity [BCVA] worse than Snellen 6/12) is associated with higher mortality, despite differences in study design, follow‐up periods, definition of ocular conditions and variables adjusted for statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Well‐known factors associated with increased long‐term mortality include increasing age, male sex, low socio‐economic status and chronic disease. Vision is also an important variable associated with mortality and has been investigated by studies in various populations …”

Section: Introductionmentioning

confidence: 99%

Ten‐year all‐cause mortality and its association with vision among Indigenous Australians within Central Australia: the Central Australian Ocular Health Study

Liu

Kahawita

et al. 2017

Clinical Exper Ophthalmology

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The 10-year all-cause mortality rate of Indigenous Australians over the age of 40 years and living in remote communities of Central Australia was 29.3%. This is more than double that of the Australian population as a whole. Mortality was significantly associated with visual acuity at recruitment. Further work designed to better understand this association is warranted and may help to reduce this disparity in the future.

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Association between lens opacities and mortality in the Priverno Eye Study

Abstract: The analysis of the Priverno data seems to confirm an association between lower survival and cataracts, particularly those confined to the lens nucleus and those that had already prompted surgery.

Cited by 16 publications

References 27 publications

Risk factors for retinal detachment following cataract surgery: the impact of posterior capsular rupture

Risk factors for retinal detachment following cataract surgery: the impact of posterior capsular rupture

Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis

Ten‐year all‐cause mortality and its association with vision among Indigenous Australians within Central Australia: the Central Australian Ocular Health Study

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