Association between left atrial strain and left ventricular diastolic function in patients with acute coronary syndrome

Fernandes, Rafael Modesto; Bihan, David Costa de Souza Le; Vilela, Andréa Andrade; Barretto, Rodrigo B M; Santos, Elizabete Silva dos; Assef, Jorge Eduardo; Pedra, Simone Fontes; Sousa, Amanda G.M.R.; Timerman, Ari

doi:10.1007/s12574-018-0403-7

Cited by 16 publications

(16 citation statements)

References 31 publications

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“…The ratio of transmitral E wave velocity to left ventricular diastolic parameter, such as E/Ea and E/left ventricular early diastolic strain rate, had a significant correlation with left ventricular filling pressure [12,24] and could usefully predict mortality in various populations, including in patients with heart failure with reduced ejection fraction [25], in the general population [25], and in patients with acute myocardial infarction [26,27]. Many previous studies have shown that LA strain has a significant correlation with left ventricular diastolic function [28][29][30]. In the present study, we also found LA strain had a significant correlation with Ea, an established left ventricular diastolic parameter, so the combination index, E/LA strain, should have a significant correlation with left ventricular filling pressure and a potential to predict mortality.…”

Section: Discussionmentioning

confidence: 99%

Ratio of Transmitral E Wave Velocity to Left Atrial Strain as a Useful Predictor of Total and Cardiovascular Mortality in Hemodialysis Patients

Tsai

Lee

et al. 2019

JCM

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The ratio of transmitral E-wave velocity (E) to a left ventricular diastolic parameter is reported to be well correlated with left ventricular filling pressure and is useful in the prediction of mortality. Left atrial (LA) strain has been demonstrated to be associated with left ventricular diastolic function. The aim of the study is to examine the ability of E/LA strain in predicting total and cardiovascular mortality in hemodialysis (HD) patients. In 197 routine HD patients, global LA strain during the reservoir phase was estimated by taking the average of longitudinal strain data obtained from the apical four-chamber and two chamber views by two-dimensional speckle tracking echocardiography. Twenty-nine total mortality and 14 cardiovascular mortality were documented during the 2.7 ± 0.6-year follow-up. After adjusting age, comorbidities, albumin, E/early diastolic mitral annular velocity (Ea), and LA strain, increased E/LA strain (hazard ratio (HR) = 1.191, 95% confidence interval (CI) = 1.072−1.324, p = 0.001) was still associated with increased total mortality. After adjusting age, comorbidities, albumin, E/Ea, left ventricular ejection fraction, and LA strain, increased E/LA strain (HR = 1.195, 95% CI = 1.041−1.372, p = 0.011) was still associated with increased cardiovascular mortality. In conclusion, E/LA strain is a useful parameter in the prediction of total and cardiovascular mortality in HD patients. Hence, E/LA strain deserves to be calculated in HD patients for better survival prediction.

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Section: Discussionmentioning

confidence: 99%

Ratio of Transmitral E Wave Velocity to Left Atrial Strain as a Useful Predictor of Total and Cardiovascular Mortality in Hemodialysis Patients

Tsai

Lee

et al. 2019

JCM

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“…Secondly, the system was originally developed for the prediction of a clinical event, but not the categorization of functional impairment. Notwithstanding these shortcomings, a Absolute value of B is presented b Adjusted according to systolic blood pressure, heart rate, hemoglobin levels, low-density lipoprotein levels, cigarette smoking, left circumflex artery stenosis, singlevessel disease, obesity, and nitrate use CI, confidence interval; LAScd, left atrial longitudinal strain during the conduit phase; LASct, Left atrial longitudinal strain during the contraction phase; LASr, Left atrial longitudinal strain during the reservoir phase; pLASRcd, peak left atrial longitudinal strain rate during the conduit phase; pLASRct, Peak left atrial longitudinal strain rate during the contraction phase; pLASRr, peak left atrial longitudinal strain rate during the reservoir phase LA function is not completely independent of LV systolic and diastolic functions insofar as LV systolic and diastolic dysfunction can lead to LA dysfunction [37,38]. The factors incorporated in the CHA 2 DS 2 -VASc scoring system can impair LV systolic and diastolic functions.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the ability of the CHA2DS2-VASc scoring system to grade left atrial function by 2D speckle-tracking echocardiography

Hadadi

Mohseni-Badalabadi

Hosseinsabet

2021

BMC Cardiovasc Disord

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Background The CHA2DS2-VASc scoring system is correlated with left atrial (LA) reservoir function in patients with atrial fibrillation (AF) rhythm or paroxysmal AF. We assessed the ability of CHA2DS2-VASc to grade LA function in patients with sinus rhythm who were candidates for coronary artery bypass grafting (CABG). Methods This cross-sectional study recruited 340 consecutive candidates for CABG and categorized them according to their CHA2DS2-VASc scores as mild-, moderate-, and high-risk score groups with 34 (10%), 83 (24%), and 223 (66%) patients, respectively. LA function was evaluated via 2D speckle-tracking echocardiography in terms of global longitudinal strain and strain rate during the reservoir, conduit, and contraction phases. In-hospital mortality, postoperative AF, prolonged intensive care unit (ICU) stay, and prolonged mechanical ventilation were assessed. Results LA strain and strain rate during the reservoir phase was statistically significantly lower in the high-risk score group than the low- and moderate-risk score groups (27.8 ± 6.9% vs 31.0 ± 5.0% vs 29.8 ± 6.1%, respectively; P = 0.004 and 2.6 ± 0.7 s−1 vs 2.9 ± 0.6 s−1 vs 2.9 ± 0.6 s−1, correspondingly; P = 0.009) and regarding LA strain and strain rate during the conduit phase (9.7 [7.1–12.5]% vs 12.9 [9.4–15.1]% vs 11.5 [9.1–13.8]%, correspondingly; P < 0.001 and 2.1 [1.6–2.7] s−1 vs 2.8 [2.4–3.6] s−1 vs 2.6 [2.2–3.0] s−1, respectively; P < 0.001). In addition, LA strain rate during the conduit phase was lower in the moderate-risk score group than the low-risk score group. After adjustments for possible confounders, these differences remained statistically significant. The risk of postoperative AF and prolonged ICU stay was highest in the high-risk score group (relative risk = 9.67 (1.31–71.43) and 8.05 (1.08–60.16), respectively; P = 0.026 and P = 0.042, respectively). Conclusions LA reservoir and conduit functions decreased in the high-risk score group, which was accompanied by an increased risk of postoperative AF and prolonged ICU stay.

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“…4, 16 Recently, peak atrial longitudinal strain has been suggested as a reliable method for the evaluation of LA dysfunction, and it is applicable for acute MI. 17, 18 However, strain analysis requires special equipment, as well as standardization and validation, and there are inter-vendor variability in strain imaging. 19 Therefore, we believe that the greatest merit of a′ is that it is a simple and easily repeatedly measured index that could be a useful and reliable marker of LA function.…”

Section: Data Availabilitymentioning

confidence: 99%

Clinical Significance of Late Diastolic Tissue Doppler Velocity at 24 Hours or 14 Days After Onset of ST-Elevation Acute Myocardial Infarction

et al. 2021

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Background:The significance of late diastolic velocity (a′) obtained by tissue Doppler imaging (TDI), which reveals atrial function, in ST-elevation myocardial infarction (STEMI) remains unclear. This study evaluated the association of TDI parameters determined either immediately or 2 weeks after percutaneous coronary intervention (PCI) with long-term outcomes. Methods and Results:In all, 740 patients with first-time STEMI underwent immediate PCI (i.e., within 12 h of onset). Echocardiography was performed in 307 patients 2 weeks after onset (Group A; mean age 64 years, 249 males), in 277 patients immediately after PCI (Group B; mean age 65 years, 229 males), and in 156 patients twice (i.e., immediately and 2 weeks after PCI; Group C; mean age 65 years, 135 males). Patients were followed-up for up to 10 years (mean 81 months). The primary endpoints were cardiac death or heart failure hospitalization. Major adverse cardiovascular events (MACE) occurred in 143 patients (19%) during the follow-up period. Both univariate and multivariate Cox hazard analyses were used to determine predictors of MACE. At 24 h and 2 weeks after STEMI onset, a′ and E/e′ were the strongest predictors of MACE, respectively.Conclusions: TDI parameters have different implications depending on the timing of echocardiography after a first-time STEMI. Based on the results of this study, atrial dysfunction measured by TDI 24 h after STEMI onset may indicate a poor prognosis.

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Association between left atrial strain and left ventricular diastolic function in patients with acute coronary syndrome

Cited by 16 publications

References 31 publications

Ratio of Transmitral E Wave Velocity to Left Atrial Strain as a Useful Predictor of Total and Cardiovascular Mortality in Hemodialysis Patients

Ratio of Transmitral E Wave Velocity to Left Atrial Strain as a Useful Predictor of Total and Cardiovascular Mortality in Hemodialysis Patients

Assessment of the ability of the CHA2DS2-VASc scoring system to grade left atrial function by 2D speckle-tracking echocardiography

Clinical Significance of Late Diastolic Tissue Doppler Velocity at 24 Hours or 14 Days After Onset of ST-Elevation Acute Myocardial Infarction

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