Association Between Laryngopharyngeal Reflux and Radiation-induced Mucositis in Head and Neck Cancer

Eguchi, Kohtaro; Suzuki, Masami; Ida, Shota; Mori, Keita; Imai, Hisao; Kudo, Shigehiro; Ando, Ken; Higuchi, Keiko; Ebara, Takeshi

doi:10.21873/anticanres.12247

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…LPR has been demonstrated to be not only a potential factor for LCG development, but also an independent risk factor for severe radiation-induced mucositis in the prelaryngeal area. Previously, Eguchi et al ( 24 ) reported that patients with a high RFS, indicating high LPR likelihood before radiation, were more susceptible to radiation damage and developed severe laryngeal mucositis earlier than patients with low LPR likelihood. When PPI therapy was administrated, the mucositis was quickly ameliorated ( 25 ).…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, we believe that under chronic stress of LPR, the laryngeal mucosa may be vulnerable to irradiation damage and may well facilitate radiation-related LCG formation after radiation. Following Eguchi et al ’s study ( 24 ), we used the RFS for LPR assessment before radiotherapy in our series. Unexpectedly, LCG tended to develop sooner post radiation in the high LPR likelihood group than in the low LPR likelihood group but had a longer remission time.…”

Section: Discussionmentioning

confidence: 99%

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Laryngeal contact granuloma after radiotherapy in patients with nasopharyngeal carcinoma: a case series

Mo¹,

Chen²,

Huang³

et al. 2023

Ann Transl Med

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Background Laryngeal contact granuloma (LCG) is a benign hypertrophic lesion and phonatory injury after abnormal vocal behavior is regarded as its major etiology. Patients receiving radiation for non-laryngeal head and neck tumors are troubled by persistent voice impairment. The occurrence of LCG after radiotherapy for nasopharyngeal carcinoma (NPC) in our practice has implored us to re-exam their underlying etiology. We hypothesize that a proportion of LCG results from voice change caused by non-laryngeal head and neck cancer radiotherapy and firstly describe a distinct LCG population originated after radiotherapy for NPC with respect to the clinical profile, presentation, prognosis and response to treatment of patients. Methods We retrospectively reviewed the laryngoscopic examination and tumor study findings to elucidate the common clinical features of patients who presented with LCG after radiotherapy for NPC. All patients were regularly monitored with telescopic examination until lesions disappeared. Data on age, sex, clinical presentation, telescopic findings, management, latency time of lesion formation, remission time and clinical outcome were reviewed. Results The medical review identified 27 cases of LCG secondary to radiotherapy for NPC. All lesions had been diagnosed during routine endoscopy following radiation. The interval between radiation onset and endoscopic diagnosis was 3.77 months (range, 0.67–11 months). 20 cases were resolved through simple observation, 4 cases were resolved with the administration of proton pump inhibitors (PPIs), and 3 cases with a poor response to PPI therapy required subsequent surgical resection. The mean remission time in the observation and PPI groups was 4.42 months (range, 0.73–18.9 months) and 5.78 months (range, 2.17–14.63 months), respectively. All patients recovered completely and none experienced recurrence during a mean follow-up of 32.44 months (range, 5.6–71.67 months). Conclusions Iatrogenic granulomas of vocal process are presenting after radiation for non-laryngeal head and neck cancers. In contrast with spontaneous granulomas, these granulomas can be cured at high remission rates and low recurrence trend without specific intervention. Thus, simple observation may be sufficient for radiation-induced LCG.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Laryngeal contact granuloma after radiotherapy in patients with nasopharyngeal carcinoma: a case series

Mo¹,

Chen²,

Huang³

et al. 2023

Ann Transl Med

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“…Pyrosis can also contribute to the development of stomatitis; in fact, it represents an inflammatory alteration to the mucosa of the upper gastrointestinal (GI) tract, most frequently occurring as a consequence of excessive acid reflux from the stomach to the esophagus or even the laryngopharynx [35]. Some preliminary studies have identified possible associations between chronic gastro-esophageal or laryngeal reflux disease and an increased onset of H&N cancers, particularly within the larynx [36]. Moreover, a higher severity of reflux disease has been described as a potential, significant risk factor for more serious radiation-induced mucositis in patients with stage I-II laryngeal and hypopharyngeal cancers [36].…”

Section: Stomatitismentioning

confidence: 99%

“…Some preliminary studies have identified possible associations between chronic gastro-esophageal or laryngeal reflux disease and an increased onset of H&N cancers, particularly within the larynx [36]. Moreover, a higher severity of reflux disease has been described as a potential, significant risk factor for more serious radiation-induced mucositis in patients with stage I-II laryngeal and hypopharyngeal cancers [36].…”

Section: Stomatitismentioning

confidence: 99%

Nutritional Management of Oncological Symptoms: A Comprehensive Review

Garutti,

Noto,

Pastò

et al. 2023

Nutrients

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Throughout their experience of illness and during the course of treatment, a substantial proportion of cancer patients are prone to develop nutritional and/or metabolic disturbances. Additionally, cancer patients often encounter long-term side effects from therapies, which may lead to impaired digestion, nutrient absorption or bowel motility. Therefore, the preservation and maintenance of an optimal and balanced nutritional status are pivotal to achieving a better prognosis, increasing the tolerance and adherence to cancer therapies and improving the overall quality of life. In this context, personalized nutritional programs are essential for addressing conditions predisposing to weight loss, feeding difficulties, digestion problems and intestinal irregularity, with the goal of promoting adequate nutrient absorption and minimizing the detrimental effects of treatment regimens. The focus of this research is to examine the most common clinical conditions and metabolic changes that cancer patients may experience, including stomatitis, xerostomia, diarrhea, nausea, vomiting, dysphagia, sub-occlusion, dysgeusia, dysosmia, anorexia, and cachexia. Furthermore, we present a pragmatic example of a multidisciplinary workflow that incorporates customized recipes tailored to individual clinical scenarios, all while maintaining the hedonic value of the meals.

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Association between salivary secretary function and laryngopharyngeal reflux: a prospective study

Kim

Park

et al. 2019

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Association Between Laryngopharyngeal Reflux and Radiation-induced Mucositis in Head and Neck Cancer

Abstract: High RFS (i.e., increased likelihood of LPR) appears to be a potential risk factor for developing severe radiation-induced mucositis.

Cited by 4 publications

References 11 publications

Laryngeal contact granuloma after radiotherapy in patients with nasopharyngeal carcinoma: a case series

Laryngeal contact granuloma after radiotherapy in patients with nasopharyngeal carcinoma: a case series

Nutritional Management of Oncological Symptoms: A Comprehensive Review

Association between salivary secretary function and laryngopharyngeal reflux: a prospective study

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