Association Between Large Numbers of Enlarged Perivascular Spaces in Basal Ganglia and Motor Performance in Elderly Individuals: A Cross-Sectional Study

Yang, Shuna; Li, Xuanting; Qin, Wei; Yang, Lei; Hu, Wenli

doi:10.2147/cia.s364794

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…The RUN DMC study concluded that WMH in the BG and lacunar infarcts in the thalamus are associated with lower velocities ( 32 ). And the latest study found that large numbers of BG-EPVS were related to lower gait speed and shorter stride length ( 33 ), which is consistent with our results. The degree of CSO-EPVS is associated with a higher incidence of CAA intracerebral hemorrhage, as well as lobar CMB ( 34 ).…”

Section: Discussionsupporting

confidence: 92%

Association of enlarged perivascular spaces with upper extremities and gait impairment: An observational, prospective cohort study

Hou

Yang

et al. 2022

Front. Neurol.

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Background and objectiveGait disturbances are common in the elderly and can lead to the loss of functional independence and even death. Enlarged perivascular space (EPVS) and motor performance may be related, but only few studies have explored this relationship. The aim of our study was to investigate the effects of both the severity and location of EPVS on movement disorders.MethodTwo hundred and six participants aged between 45 and 85 years old with complete magnetic resonance imaging (MRI) data were included in our analysis. EPVS were divided into basal ganglia (BG) and centrum semiovale (CSO), and their grades were measured. Gait was assessed quantitatively using a 4-m walkway and TUG test as well as semi-quantitatively using the Tinetti and SPPB tests. The function of upper extremities was evaluated by 10-repeat pronation–supination, 10-repeat finger-tapping, and 10-repeat opening and closing of the hands.ResultsBoth high-grade EPVS, whether in BG and CSO, were independently correlated with gait parameters, the TUG time, Tinetti, and SPPB tests. The EPVS located in BG had a significant association with 10-repeat finger-tapping time (β = 0.231, P = 0.025) and a similar association was also observed between CSO-EPVS and 10-repeat pronation–supination time (β = 0.228, P = 0.014).ConclusionOur results indicated that EPVS was associated with gait disturbances, and a further investigation found that EPVS has an association with upper extremities disorder. EPVS should be considered as a potential target for delaying gait and upper extremities damage since CSVD can be prevented to some extent.

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Section: Discussionsupporting

confidence: 92%

Association of enlarged perivascular spaces with upper extremities and gait impairment: An observational, prospective cohort study

Hou

Yang

et al. 2022

Front. Neurol.

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“…Personally, this reviewer believes that some of these conclusions are somewhat rigid but interested readers can find the original papers thereby included. Additionally, new research shows that enlarged perivascular spaces per se are also associated with gait and balance dysfunction [ 25 , 26 ].…”

Section: Small Vessel Disease and Balancementioning

confidence: 99%

Vascular neuro-otology: vestibular transient ischemic attacks and chronic dizziness in the elderly

Bronstein,

Kattah

2023

Current Opinion in Neurology

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Purpose of review To explore the differential diagnosis of posterior fossa transient ischemic attacks (TIA) associated with vertigo and/or imbalance. To review the contribution of cerebral small vessel (SVD) disease to balance dysfunction and dizziness in the elderly. Main findings TIAs involving vestibular structures that mediate the vestibulo-ocular and vestibulospinal reflexes remain a diagnostic challenge because they overlap with causes of benign episodic vertigo. Here, we summarize the results of multidisciplinary specialty efforts to improve timely recognition and intervention of peripheral and central vestibular ischemia. More papers confirm that SVD is a major cause of gait disability, falls and cognitive disorder in the elderly. Recent work shows that early stages of SVD may also be responsible for dizziness in the elderly. The predominant location of the white matter changes, in the frontal deep white matter and genu of the corpus callosum, explains the association between cognitive and balance dysfunction in SVD related symptoms. Summary The evaluation of patients with intermittent vascular vertigo represent a major diagnostic challenge, recent reviews explore the ideal design approach for a multidisciplinary study to increase early recognition and intervention. Hemispheric white matter microvascular ischemia has been the subject of research progress - advanced stages are known to cause gait disorder and dementia but early stages are associated with “idiopathic” dizziness in the elderly.

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Single- and dual-task gait parameters in determination of cerebral small vessel disease

He,

Huang,

et al. 2024

Preprint

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Background and objective: Gait disorder is one of the primary symptoms of cerebral small vessel disease (CSVD) and its potential diagnostic value was not known. We aimed to investigate the gait performance in CSVD and to determine the diagnostic value of gait parameters for CSVD under single-task and dual-task walking conditions. Methods: We prospectively recruited consecutive patients with CSVD from January 1, 2022 to August 31, 2023. A total of 129 CSVD patients and 71 healthy controls were enrolled. Direct gait parameters in the patient group and the control group were compared under single-task and dual-task conditions, controlling for covariates. Gait parameters were compared between the two groups, using the receiver operating characteristic curve. Results: Compared to controls, participants with CSVD had shorter stride length, slower stride speed, shorter cadence, longer stance time/phase, longer stride time, shorter swing phase, smaller average toe-off angle and smaller heel stride angle either in single-task walking test or in dual-task walking test (all P<0.05). Average heel strike angle could distinguish CSVD from healthy controls both in single-task (AUC = 0.858, P < 0.001, sensitivity, 83.1%; specificity, 76.7%) and dual-task walking tests (AUC = 0.865, P < 0.001, sensitivity, 91.5%; specificity, 70.5%) with moderate accuracy, independent of covariates. Conclusion: Gait patterns changed in patients with CSVD. Our findings suggest that average heel strike angle was one of the most valuable gait parameters of altered gait in CSVD and that could serve as a diagnostic marker of CSVD.

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Association Between Large Numbers of Enlarged Perivascular Spaces in Basal Ganglia and Motor Performance in Elderly Individuals: A Cross-Sectional Study

Cited by 4 publications

References 38 publications

Association of enlarged perivascular spaces with upper extremities and gait impairment: An observational, prospective cohort study

Association of enlarged perivascular spaces with upper extremities and gait impairment: An observational, prospective cohort study

Vascular neuro-otology: vestibular transient ischemic attacks and chronic dizziness in the elderly

Single- and dual-task gait parameters in determination of cerebral small vessel disease

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