Association Between Knee Pain, Impaired Function, and Development of Depressive Symptoms

Sugai, Keiko; Takeda-Imai, Fujimi; Michikawa, Takehiro; Nakamura, Takahiro; Takebayashi, Toru; Nishiwaki, Yuji

doi:10.1111/jgs.15259

Cited by 27 publications

(29 citation statements)

References 28 publications

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“…However, the genetic correlations between hip pain and knee pain and depression were contrary to previous observations that depression and knee pain or hip pain are strongly related [36]. Previous studies have shown that knee pain from osteoarthritis increases a person's risk of developing subsequent depression [37]. A systematic review of the relationship between knee pain and multiple psychiatric traits also found an association between depression and knee pain [38].…”

Section: Discussionmentioning

confidence: 60%

Genetic correlations between pain phenotypes and depression and neuroticism

et al. 2019

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Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922-226,683) with depressive symptoms, major depressive disorders and neuroticism using the the crosstrait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h 2 = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.

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Section: Discussionmentioning

confidence: 60%

Genetic correlations between pain phenotypes and depression and neuroticism

et al. 2019

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“…36 Previous studies have shown that knee pain from osteoarthritis increases a person’s risk of developing subsequent depression. 37 A systematic review of the relationship between knee pain and multiple psychiatric traits also found an association between depression and knee pain. 38 While genetic factors may contribute to the pain at different sites, our findings suggest that non-genetic factors may be more important in the co-occurrence of knee or hip pain with depression.…”

Section: Discussionmentioning

confidence: 99%

Genetic correlations between pain phenotypes and depression and neuroticism

Wang

Adams

Deary

et al. 2018

Preprint

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19Correlations between pain phenotypes and psychiatric traits such as depression and 20 the personality trait of neuroticism are not fully understood. The purpose of this study 21 was to identify whether eight pain phenotypes, depressive symptoms, major 22 depressive disorders, and neuroticism are correlated for genetic reasons. Eight pain 23 phenotypes were defined by a specific pain-related question in the UK Biobank 24 questionnaire. First we generated genome-wide association summary statistics on 25 each pain phenotype, and estimated the common SNP-based heritability of each trait 26 using GCTA. We then estimated the genetic correlation of each pain phenotype with 27 depressive symptoms, major depressive disorders and neuroticism using the the 28 cross-trait linkage disequilibrium score regression (LDSC) method integrated in the 29 LD Hub. Third, we used the LDSC software to calculate genetic correlations among 30 pain phenotypes. All pain phenotypes were heritable, with pain all over the body 31showing the highest heritability (h 2 =0.31, standard error=0.072). All pain phenotypes, 32 except hip pain and knee pain, had significant and positive genetic correlations with 33 depressive symptoms, major depressive disorders and neuroticism. The largest 34 genetic correlations occurred between neuroticism and stomach or abdominal pain 35 (rg=0.70, P=2.4 x 10 -9 ). In contrast, hip pain and knee pain showed weaker evidence 36 of shared genetic architecture with these negative emotional traits. In addition, many 37 pain phenotypes had positive and significant genetic correlations with each other 38 indicating shared genetic mechanisms. Pain at a variety of body sites is heritable 39 and genetically correlated with depression and neuroticism. This suggests that pain, 40 neuroticism and depression share partially overlapping genetic risk factors. 41 experience of pain could help our understanding of its aetiology and prevention, and 56 might also offer opportunities for personalised medicine and drug targeting based on 57 identified genetic variants. Although some genetic studies have focused on pain in 58 specific body sites and have suggested possible genetic variants associated with 59 pain phenotypes, 5 the overall understanding of the genetic contributions of pain 60 remain unclear. Current limitations in our knowledge include: 1. the extent to which 61 pain as a phenotype is determined by additive genetic components mainly 62represented by single nucleotide polymorphisms (SNPs); 2. whether the genetic 63 mechanisms of pain in different body sites or in different disorders are similar or 64 different; and 3. whether the genetic connections between pain phenotypes and 65 other common co-morbidities are similar or different. Addressing these questions 66 brings further challenges when the severity and the frequency of pain are taken into 67 account. 68 4 Mental health disorders are among the commonest co-morbidities of pain. 6-7 69Depression was ranked as the third most important cause of disability worldwide, 70 a...

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“…Additionally, musculoskeletal conditions, including knee OA, were found to occur in conjunction with other illness as a predictor of quality of life in the rural Thai population (Hongthong Somrongthong, & Ward, ). Knee OA generally causes significant chronic pain and increases difficulty in performing daily activities (Fukutani et al, ; Sugai et al, ), as it affects locomotive functions, such as walking, standing, sitting, and ascending or descending stairs. Progressive physical limitations and disability lead to diminished quality of life (Mesci, Icagasioglu, Mesci, & Turgut, ).…”

Section: Introductionmentioning

confidence: 99%

“…Progressive physical limitations and disability lead to diminished quality of life (Mesci, Icagasioglu, Mesci, & Turgut, ). Pain subsequent to knee OA also impacts well‐being through incremental fatigue (Hodges et al, ), distress, and depressive symptoms, again affecting quality of life (Sugai et al, ). The symptom cluster of pain, fatigue, and depressive symptoms is related to functional status and quality of life among older people with knee OA (Jenkins & McCoy, ).…”

Section: Introductionmentioning

confidence: 99%

Path model of factors influencing health‐related quality of life among older people with knee osteoarthritis

Aree‐Ue

Kongsombun

Roopsawang

et al. 2019

Nursing & Health Sciences

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Chronic illness has a significant effect on quality of life, and a critical measure of health outcomes. Correlations between pain, depressive symptoms, fatigue, and physical function and their direct and indirect effects on quality of life were determined among 200 Thai older population with knee osteoarthritis using the Numeric Rating Scale, the Multidimensional Assessment of Fatigue, and the Thai Geriatric Depression Scale‐15. Physical function was investigated by using the Timed Up and Go test. Path analysis revealed significant negative direct paths from pain, depressive symptoms, fatigue, and Timed Up and Go test results to quality of life. Pain, fatigue, and the Timed Up and Go test results had indirect effects on quality of life, while depressive symptoms had no indirect effect on quality of life. Increases in pain, depressive symptoms, fatigue, and Timed Up and Go test results were associated with reductions in quality of life. An understanding of the complex relationship among these variables is beneficial for designing an appropriate intervention for improving quality of life among older people with knee osteoarthritis.

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Association Between Knee Pain, Impaired Function, and Development of Depressive Symptoms

Abstract: Examining elderly people's responses to questions about pain at night and difficulties performing daily activities may be an efficient way of identifying those at high risk of developing depressive symptoms.

Cited by 27 publications

References 28 publications

Genetic correlations between pain phenotypes and depression and neuroticism

Genetic correlations between pain phenotypes and depression and neuroticism

Genetic correlations between pain phenotypes and depression and neuroticism

Path model of factors influencing health‐related quality of life among older people with knee osteoarthritis

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