Association between keratoconus and the risk of adolescent‐ or adult‐onset atopic dermatitis

Chang, Yuh Shin; Weng, Shih Feng; Wang, Jhi Joung; Tseng, Sung Huei; Wang, Jiu Yao; Jan, Han Yi; Ko, Shun Yao; Tsai, Wen Hui; Chen, Hsien Yu; Liou, Cheng Wen; Jan, Ren Long

doi:10.1111/all.14320

Cited by 6 publications

(9 citation statements)

References 12 publications

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“…The limitations of each of these studies may account for why no association between atopy and keratoconus was found, whereas the majority of studies have found significantly higher rates of atopy in keratoconus patients compared to controls [9,10,[15][16][17][18][19]. Additionally, studies have found significantly higher rates of asthma [20][21][22][23][24][25][26][27], allergic rhinitis [20,21,[23][24][25]27], atopic dermatitis [24,25], and ocular allergy [13,22,25] in keratoconus populations (Supplemental Tables S1-S4). A multivariate regression analysis found that asthma was associated with increased odds of keratoconus diagnosis, although, on the contrary, allergic rhinitis was associated with reduced odds of severe KCN compared to mild KCN [27].…”

Section: Prevalence Of Atopy Within Keratoconus Populationsmentioning

confidence: 99%

Systemic Associations with Keratoconus

Unni

Lee

2023

Life

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Keratoconus is a disease of the cornea that results in progressive steepening and thinning of the cornea and subsequent vision loss. It nearly always presents as a bilateral disease, suggesting that there is an underlying abnormality of the corneas that becomes manifest with time. However, the mechanisms underlying the development of keratoconus are largely unknown. Associations reported between keratoconus and systemic diseases are abundant in the literature, and the list of possible associations is very long. We found that atopy, Down syndrome, and various connective tissue diseases were the most frequently cited associations in our broad literature search. Additionally, Diabetes Mellitus has been increasingly studied as a possible protective factor against keratoconus. In this review, we have summarized the evidence for and against these particular systemic conditions and keratoconus and have discussed some of the implications of keratoconus patients having these conditions.

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Section: Prevalence Of Atopy Within Keratoconus Populationsmentioning

confidence: 99%

Systemic Associations with Keratoconus

Unni

Lee

2023

Life

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“…A variety of intrinsic and extrinsic risk factors were identified to influence AE development and exacerbation (Figure 1). 19 Intrinsic risk factors for AE include parental atopic history, filaggrin (FLG) mutations, polysensitization, decreased short‐chain fatty acids in the gut of children, and underlying medical conditions as keratoconus 20‐25 . However, extrinsic factors as low microbial exposure and diversity, antibiotic exposure, urban environment, tobacco smoke exposure, stress, food and pollutants are as important for AE development 16 .…”

Section: Atopic Eczema As An Environmental Diseasementioning

confidence: 99%

A new era of atopic eczema research: Advances and highlights

Hülpüsch

Weins

Traidl‐Hoffmann

et al. 2021

Allergy

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Atopic eczema (AE) or atopic dermatitis (AD) is an inflammatory skin disease with involvement of genetic, immunological and environmental factors which are highly interconnected. 1,2 The heterogenic disease can be separated into different phenotypes and clinical presentations defined by the ethnicity, disease onset, disease severity, chronic vs acute, intrinsic vs extrinsic (IgE level), paediatric vs adult and inflammatory signature. [3][4][5] A common feature of all subtypes is a tremendous psychosocial burden for all patients with AE. 6 Prevalence varies by area and is reported to be 15-20% in children in Europe, persisting in up to 5-10% of adults. [7][8][9] Although severe cases are less abundant than mild or moderate disease pattern, 2% of affected children are severely suffering. 7,9 Therefore, AE remains to be a high and even increasing socio-economic burden in the United States and in Europe, 10,11 whereas slightly decreasing numbers were reported over the last few years in Japan. 12 Children often overcome atopic eczema, but set off on the so-called 'atopic march', that is begin a classic 'allergy career'. Scientifically, AE is a risk factor for the development of allergies. These are primarily type I allergies with clinical features such as hay fever and asthma. Allergies are increasingly becoming a widespread disease. Currently, almost every fourth person in Europe suffers from symptoms such as asthma or hay fever and the associated restrictions in everyday life or at work. For society, the reduced ability to perform at school, university and at work means great socio-economic damage.

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“…A variety of intrinsic and extrinsic risk factors were identified to influence AE development and exacerbation (Figure 1) [19]. Intrinsic risk factors for AE include parental atopic history, filaggrin (FLG) mutations, polysensitization, decreased short chain fatty acids in the gut of children, and underlying medical conditions [20][21][22][23][24][25]. However, extrinsic factors as low microbial exposure and diversity, antibiotic exposure, urban environment, tobacco smoke exposure, stress, food, and pollutants are as important for AE development [16].…”

Section: Ae As An Environmental Diseasementioning

confidence: 99%

Title: A new era of atopic eczema research: Advances and highlights

Hülpüsch

Weins

Traidl‐Hoffmann

et al. 2021

Preprint

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Atopic eczema (AE) is an inflammatory skin disease with involvement of genetic, immunological, and environmental factors. One hallmark of AE is a skin barrier disruption on multiple, highly interconnected levels: filaggrin mutations, increased skin pH, and a microbiome dysbiosis towards Staphylococcus aureus overgrowth are observed in addition to an abnormal type 2 immune response. Extrinsic factors seem to play a major role in the development of AE. As AE is a first step in the atopic march, its prevention and appropriate treatment is essential. Although standard therapy remains topical treatment, powerful systemic treatment options emerged in the last years. However, thorough endotyping of the individual patients is still required for ideal precision medicine approaches in the future. Therefore, novel microbial and immunological biomarkers were described recently for the prediction of disease development and treatment response. This review summarizes the current state of the art in AE research.

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Association between keratoconus and the risk of adolescent‐ or adult‐onset atopic dermatitis

Cited by 6 publications

References 12 publications

Systemic Associations with Keratoconus

Systemic Associations with Keratoconus

A new era of atopic eczema research: Advances and highlights

Title: A new era of atopic eczema research: Advances and highlights

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