Association between JC virus and colorectal cancer: systematic review and meta-analysis

Shavaleh, Rasoul; Kamandi, Mostafa; Disfani, Hamideh Feiz; Mansori, Kamyar; Naseri, Seyede Nafiseh; Rahmani, Kazem; Kanrash, Fakhradin Ahmadi

doi:10.1080/23744235.2019.1692145

Cited by 20 publications

(21 citation statements)

References 41 publications

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“…Additionally, JCV infection increased the odds for colorectal adenoma development (6-fold) more than colorectal cancer (4.1-fold). Our findings corroborate the results of recent meta-analyses indicating that the presence of JCV in colorectal tissues increased the odds of colorectal tumors by 4.4 to 4.7 times compared to the absence of the virus [50,51] . In these studies, however, colorectal cancer and adenoma were not looked at individually, and the association of JCV infection with EO-CRC was not assessed.…”

Section: Discussionsupporting

confidence: 91%

Does Human JC Virus Play a Role in the International Variations and Temporal Trends of Early-Onset Colorectal Cancer? A Meta-Analysis

Hamid¹,

Marc-Hern醤dez

Ruíz-Tóvar

2020

Journal of Gastroenterology and Hepatology Research

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The prevalence and incidence trend of early-onset colorectal cancer (EO-CRC) exhibit wide variations across the world, which could be attributed to early-life exposures such as diet and viral infections. We carried out a systematic review and meta-analysis to examine the association between John Cunningham virus (JCV) infection and EO-CRC. Literature was searched for studies comparing the presence of JCV DNA in colorectal cancerous and non-cancerous tissues.Countries where the studies were conducted were categorized into high and low prevalence settings for EO-CRC, and according to the time-weighted average annual per cent change in incidence rates of EO-CRC into rising-trend, stable-trend, and decreasing-trend settings. A total of 19 studies with 3065 participants were included. The metaanalysis showed that JCV increased the odds for colorectal adenoma development (6-fold) more than colorectal cancer (4.1-fold), in comparison to controls. The odds for colorectal tumor development with JCV infection were significantly higher in the high-prevalence settings than in the low-prevalence settings when compared with controls and matched adjacent colorectal tissues. Similarly, the odds for colorectal tumor development trended to be higher in the risingtrend settings than in the stable-trend settings when compared with controls and matched adjacent colorectal tissues; no JCV DNA was detected in the decreasing-trend settings in both cancerous and noncancerous colorectal tissues. These results suggest that JCV is likely involved in early stage of colorectal carcinogenesis, and may play a role in the international variations and temporal trends of EO-CRC in some parts of the world.

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Section: Discussionsupporting

confidence: 91%

Does Human JC Virus Play a Role in the International Variations and Temporal Trends of Early-Onset Colorectal Cancer? A Meta-Analysis

Hamid¹,

Marc-Hern醤dez

Ruíz-Tóvar

2020

Journal of Gastroenterology and Hepatology Research

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“…Furthermore, human polyomavirus 2 (also known as JCV) was reported to possibly play a role in the carcinogenesis of CRC [105]. One meta-analysis reported JCV as an oncogene virus that could increase the likelihood of CRC [106]. T-antigen (T-Ag), a transforming gene encoded by JCV, is involved in oncogenesis by inducing the methylation of tumor suppressor gene promoters [107,108].…”

Section: Colorectal Cancermentioning

confidence: 99%

The Human Virome: Viral Metagenomics, Relations with Human Diseases, and Therapeutic Applications

Bai

Lin

Hsu

et al. 2022

Viruses

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The human body is colonized by a wide range of microorganisms. The field of viromics has expanded since the first reports on the detection of viruses via metagenomic sequencing in 2002. With the continued development of reference materials and databases, viral metagenomic approaches have been used to explore known components of the virome and discover new viruses from various types of samples. The virome has attracted substantial interest since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic. Increasing numbers of studies and review articles have documented the diverse virome in various sites in the human body, as well as interactions between the human host and the virome with regard to health and disease. However, there have been few studies of direct causal relationships. Viral metagenomic analyses often lack standard references and are potentially subject to bias. Moreover, most virome-related review articles have focused on the gut virome and did not investigate the roles of the virome in other sites of the body in human disease. This review presents an overview of viral metagenomics, with updates regarding the relations between alterations in the human virome and the pathogenesis of human diseases, recent findings related to COVID-19, and therapeutic applications related to the human virome.

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“…Previous studies had shown a higher prevalence of BKPyV in urothelial and renal cancers and of JCPyV in brain tumors and colorectal cancers, compared to healthy tissue [ (Delbue et al, 2014;Keller et al, 2015;Starrett and Buck, 2019;Shavaleh et al, 2020;Shoraka et al, 2020); see Supplementary Table 1]. MCPyV is associated with approximately 80% of all MCC cases (Arora et al, 2012;Becker et al, 2017;Pietropaolo et al, 2020).…”

Section: Detection Of Novel Human Polyomaviruses In Tumor Samplesmentioning

confidence: 97%

“…Although the JCPyV LT-ag:β-catenin interaction was described in mouse medulloblastoma and in glioblastoma cell lines, it has been recently detected in human colorectal carcinoma, in which β-catenin and Wnt pathway are frequently increased (Enam et al, 2002). This suggests a role of JCPyV in colorectal malignancy through activation of the Wnt pathway, although JCPyV detection is frequent in both normal colorectal and colorectal cancer tissues [ (Shavaleh et al, 2020;Shoraka et al, 2020); Supplementary Table 1]. Infection of human bladder cancer cells with BKPyV activated the β-catenin signaling pathway, but an interaction between LT-ag and β-catenin was not investigated (Zeng et al, 2020).…”

Section: Novel Human Polyomaviruses and The Wnt Pathwaymentioning

confidence: 99%

Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer

2022

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As their name indicates, polyomaviruses (PyVs) can induce tumors. Mouse PyV, hamster PyV and raccoon PyV have been shown to cause tumors in their natural host. During the last 30 years, 15 PyVs have been isolated from humans. From these, Merkel cell PyV is classified as a Group 2A carcinogenic pathogen (probably carcinogenic to humans), whereas BKPyV and JCPyV are class 2B (possibly carcinogenic to humans) by the International Agency for Research on Cancer. Although the other PyVs recently detected in humans (referred to here as novel HPyV; nHPyV) share many common features with PyVs, including the viral oncoproteins large tumor antigen and small tumor antigen, as their role in cancer is questioned. This review discusses whether the nHPyVs may play a role in cancer based on predicted and experimentally proven functions of their early proteins in oncogenic processes. The functional domains that mediate the oncogenic properties of early proteins of known PyVs, that can cause cancer in their natural host or animal models, have been well characterized and we examined whether these functional domains are conserved in the early proteins of the nHPyVs and presented experimental evidence that these conserved domains are functional. Furthermore, we reviewed the literature describing the detection of nHPyV in human tumors.

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Association between JC virus and colorectal cancer: systematic review and meta-analysis

Cited by 20 publications

References 41 publications

Does Human JC Virus Play a Role in the International Variations and Temporal Trends of Early-Onset Colorectal Cancer? A Meta-Analysis

Does Human JC Virus Play a Role in the International Variations and Temporal Trends of Early-Onset Colorectal Cancer? A Meta-Analysis

The Human Virome: Viral Metagenomics, Relations with Human Diseases, and Therapeutic Applications

Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer

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