Association between Iron Supplementation, Dietary Iron Intake and Risk of Moderate Preterm Birth: A Birth Cohort Study in China

Shao, Yawen; Mao, Baohong; Qiu, Jie; Bai, Yan; Lin, Ru; He, Xiaoxuan; Lin, Xiaojuan; Lv, Ling; Tang, Zhongfeng; Zhou, Min; Xu, Xiaoying; Yi, Bin; Liu, Qing

doi:10.18502/ijph.v50i6.6416

Cited by 6 publications

(4 citation statements)

References 31 publications

(32 reference statements)

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“…Dietary information was collected via a semi-quantitative food frequency questionnaire. Daily dietary vitamin A, C, E (VA, VC, VE), folate, and carotene intake was estimated from the frequency of consumption and portion size of food items using the Chinese Standard Tables of Food Consumption [26] for each time period, this estimation has been used and validated by another birth cohort conducted in Lanzhou site [30,31]. Information on vitamin or mineral supplements were asked for the following four time periods: pre-conception (12 months before pregnancy), first trimester (1-13 weeks), second trimester (14-27 weeks) and third trimester (> 27 weeks).…”

Section: Dietary Intake and Supplementationmentioning

confidence: 99%

Effects of Benzo[a]pyrene-DNA adducts, dietary vitamins, folate, and carotene intakes on preterm birth: a nested case–control study from the birth cohort in China

Zhao

Cui

et al. 2022

Environ Health

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Background Polycyclic aromatic hydrocarbons (PAHs) and its DNA adducts has been suggested to increase the risk of preterm birth (PB). Yet, few studies have been conducted to investigate this association, and the role of dietary nutrients intakes including vitamins, folate, and carotene during pre- and post-conception on this association has not been studied. Methods Building upon a birth cohort in Taiyuan China, we conducted a nested case control study including 83 PB and 82 term births. Benzo[a]pyrene (BaP)-DNA adducts were measured by an improved LC-MC/MC analytic method. Dietary nutrient intakes were estimated from food frequency questionnaire using the Chinese Standard Tables of Food Consumption. Multivariable logistic regression model was used to examine the associations. Results Increased risk of PB was observed as per interquartile increase in maternal BaP-DNA adduct level (OR = 1.27, 95%CI 0.95–1.67). Compared to low level (below mean) of maternal adducts, high level (above mean) of adducts was associated with the risk of PB (OR = 2.05, 95%CI 1.05–4.01). After stratified by dietary nutrients intakes, high adducts levels were associated with approximately 2–fourfold times increases in risk of PB among women with low vitamin A, C, E, folate, and carotene intakes during pre- and/or post-conception. Stronger stratified associations were consistently seen during preconception. Similar patterns were observed after additional adjustment for supplementation. Conclusions Our study supports the hypothesis that high level of maternal PAHs exposure was significantly associated with increased risk of PB, and provides the first evidence that dietary vitamins, carotene, and folate intake levels may modify this association during different pregnancy windows. Our findings are relevant to identify recommendation for environment management and prenatal nutrition regarding pregnant women and newborns. Further investigation in other populations is warranted.

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Section: Dietary Intake and Supplementationmentioning

confidence: 99%

Effects of Benzo[a]pyrene-DNA adducts, dietary vitamins, folate, and carotene intakes on preterm birth: a nested case–control study from the birth cohort in China

Zhao

Cui

et al. 2022

Environ Health

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“…As iron inadequacy leads to functional impairment and excess leads to cytotoxicity, the dose of iron supplementation remains debatable; hence further studies need to focus on the amount and duration of supplementation. 45,46,49 Magnesium Many studies reported a reduced incidence of preterm delivery with magnesium given to the mother <12 hours before delivery. 47,48 PROM has been linked with lower serum magnesium in mothers and higher in the placenta, implying distinct pathophysiological roles for magnesium compared to preterm birth (Figure 3).…”

Section: Ironmentioning

confidence: 99%

Micronutrients in Adverse Pregnancy Outcomes

et al. 2022

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About 10 to 20% of reported pregnancies have complications like spontaneous abortion (SA), preeclampsia (PE), preterm birth (PTB), and fetal growth restriction (FGR); 60% are attributed to maternal nutritional alterations. Multiple micronutrients (MMN) are supplemented in the antenatal period, but no proper validation/guidelines are available regarding dosing/time, the need for initiation, and the duration of supplementation. Studies have reported adverse pregnancy complications related to the overuse/unwanted use of multiple micronutrient supplementations during pregnancy. Identifying the exact population requiring supplementation is necessary to prevent its abuse. This article attempts to review the impacts of micronutrient deficiency/supplementation in cases of SA, FGR, and gestational diabetes mellitus (GDM), preterm delivery and PE. The study used a literature search using PubMed, Google Scholar, Mendeley, and Scopus Databases using search words pregnancy, spontaneous abortion, gestational diabetes mellitus (GDM), fetal growth restriction (FGR), preterm delivery, preeclampsia (PE) or “adverse pregnancy” associated with minerals, micronutrients, or supplementation. The review also considered in-house literature databases, a single-window search at Kasturba Medical College (KMC) Health sciences library, MAHE (Manipal Academy of Higher Education). The figures included in the study were created by Biorender.com. Micronutrients play multiple roles during pregnancy and fetoplacental growth stimulating growth hormone secretion, Lysyl oxidase (LOX), involved in the crosslinking between collagen and elastin in the amniotic membrane, downregulation of interleukin (IL)-1 alpha, IL-1 beta, IL-4, IL-6, Il-10, IL-12, tumor necrosis factor (TNF)-alpha and several chemokines involved in hypertension, immune-inflammatory pathways, attenuate insulin resistance a structural development of neurons and glia. Over-supplementation has led to complications such as spontaneous abortion and gestational diabetes mellitus. Since there is a lack of standardization concerning micronutrient supplementation during pregnancy, there is a need for systematic study related to the role of micronutrients during each trimester of pregnancy to optimize its supplementation and to prevent hazards associated with its abuse.

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“…It is known that essential trace elements (ETE), such as Fe, Cu, Zn, Se, Sr and Mo, are crucial for the fundamental metabolic processes, maintenance of cell proliferation and function, and play critical role in supporting successful pregnancy (13)(14)(15)(16) . Some studies have reported significant associations between the deficiency of trace elements and increased risk of PTB, or in other words, associations between the supplement of trace elements and decreased risk of PTB, including Fe (17)(18)(19)(20)(21) , Cu (22) , Zn (21,23,24) , Se (25)(26)(27)(28) and Sr (24) . However, some studies have revealed that the intake of trace elements were significantly associated with increased risk of PTB, including Fe (29)(30)(31) , Cu (31)(32)(33)(34)(35) and Zn (35)(36)(37) .…”

mentioning

confidence: 99%

“…Thus far, previous studies examining the association between prenatal exposure to essential trace minerals and PTB have yielded inconsistent results, and most of them have focused on overall PTB. Several studies have classified PTB and analysed SPTB separately, but the sample size is relatively small (20,21,(31)(32)(33)37) .…”

mentioning

confidence: 99%

Inverse association between maternal serum concentrations of trace elements and risk of spontaneous preterm birth: a nested case–control study in China

Li,

Yu,

Liu

et al. 2024

Br J Nutr

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Few studies have evaluated the joint effect of trace elements on spontaneous preterm birth (SPTB).This study aimed to examine the relationships between the individual or mixed maternal serum concentrations of iron (Fe), copper (Cu), zinc (Zn), selenium (Se), strontium (Sr) and molybdenum (Mo) during pregnancy, and risk of SPTB. Inductively coupled plasma mass spectrometry was employed to determine maternal serum concentrations of the six trace elements in 192 cases with SPTB and 282 controls with full-term delivery. Multivariate logistic regression, weighted quantile sum regression (WQSR) and Bayesian kernel machine regression (BKMR) were used to evaluate the individual and joint effects of trace elements on SPTB. The median concentrations of Sr and Mo were significantly higher in controls than in SPTB group (P < 0.05). In multivariate logistic regression analysis, compared with the lowest quartile levels of individual trace elements, the third- and fourth-quartile Sr or Mo concentrations were significantly associated with reduced risk of SPTB with adjusted odds ratios (aORs) of 0.432 (95% confidence interval (CI): 0.247-0.756), 0.386 (95% CI: 0.213-0.701), 0.512 (95% CI:0.297-0.883), and 0.559 (95% CI: 0.321-0.972), respectively. WQSR revealed the inverse combined effect of the trace elements mixture on SPTB (aOR: 0.368, 95%CI: 0.228-0.593). BKMR analysis confirmed the overall mixture of the trace elements was inversely associated with the risk of SPTB, and the independent effect of Sr and Mo was significant. Our findings suggest that the risk of SPTB decreased with concentrations of the six trace elements, with Sr and Mo being the major contributors.

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Association between Iron Supplementation, Dietary Iron Intake and Risk of Moderate Preterm Birth: A Birth Cohort Study in China

Cited by 6 publications

References 31 publications

Effects of Benzo[a]pyrene-DNA adducts, dietary vitamins, folate, and carotene intakes on preterm birth: a nested case–control study from the birth cohort in China

Effects of Benzo[a]pyrene-DNA adducts, dietary vitamins, folate, and carotene intakes on preterm birth: a nested case–control study from the birth cohort in China

Micronutrients in Adverse Pregnancy Outcomes

Inverse association between maternal serum concentrations of trace elements and risk of spontaneous preterm birth: a nested case–control study in China

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