Association between iron‐deficiency anemia and depression: A web‐based Japanese investigation

Hidese, Shinsuke; Saito, Kenji; Asano, Shinya

doi:10.1111/pcn.12656

Cited by 67 publications

(53 citation statements)

References 35 publications

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“…In the Hidese et al . study a significant association was found between iron‐deficiency anemia and depression . In our study, iron in the diet reduced the risk of depression.…”

Section: Discussionsupporting

confidence: 64%

Screening of depression in overweight and obese pregnant women and its predictors

Salehi‐Pourmehr

Dolatkhah

Gassab-Abdollahi

et al. 2019

J of Obstet and Gynaecol

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Aim: The aim of this study was to investigate the screening result of depression and its predictors in overweight and obese pregnant women in second and third trimester of pregnancy. Methods: The present cross-sectional study was carried out on 232 overweight or obese pregnant women older than 18 years in the second and third trimesters of pregnancy. Edinburgh Postnatal Depression Scale questionnaire, the International Physical Activity Questionnaire and the Food Record were used. Independent t-test, Man-Whitney U, Pearson and Spearman correlation test, independent t-test, one-way analysis of variance and, multivariate linear regression were applied for data analysis using SPSS 21.Results: The results of the study showed that the mean (standard deviation) score of depression was 10.1 (4.4), and it was similar in both overweight and obese women (P = 0.784). Median (quartile 25-75) of physical activity was 891.0 (495.0-1336.0) metabolic equivalent of task -min/week. The total physical activity in obese women was statistically higher than overweight ones (P = 0.032). In linear regression model, the variables of parity, body mass index, physical activity education, protein, fat, oleic acid, monounsaturated fatty acids, potassium, magnesium, and zinc were the strong predictors of depression, and along with the others explained the 80% of variances. Conclusion: Considering the fact that nearly one-third of overweight and obese women in the present study were positive for depression screening, it is important to pay attention to strong predictors of depression in these women.

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“…In the Hidese et al . study a significant association was found between iron‐deficiency anemia and depression . In our study, iron in the diet reduced the risk of depression.…”

Section: Discussionsupporting

confidence: 64%

Screening of depression in overweight and obese pregnant women and its predictors

Salehi‐Pourmehr

Dolatkhah

Gassab-Abdollahi

et al. 2019

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…A hospital-based case-control study with 100 cases and 100 controls showed a relationship between IDA and depressive disorder; and the severity of symptoms of depressive disorder increased with the degree of IDA [15]. A web-based survey, which consisted of 1,000 individuals and 10,876 controls, indicated that IDA was associated with a self-reported history of depression [26]. A case-control study which included 2,957 IDA patients and 11,828 healthy controls showed a higher risk of psychiatric disorders, including mood disorders, autism spectrum disorder, attention deficit hyperactivity disorder, and developmental disorders [14].…”

Section: Discussionmentioning

confidence: 99%

Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis

Lee

Chao

Huang

et al. 2020

Preprint

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Background: It has been shown that iron deficiency anemia (IDA) is associated with psychosocial consequences and psychiatric morbidity. However, the association between adults with IDA and psychiatric disorders has not been clarified. The purpose of this study was to investigate the psychiatric disorder morbidity of an IDA group in comparison with a non-IDA group and to examine the risk of psychiatric disorders in IDA patients treated with iron supplementation. Methods: All study subjects were 20 years of age or over with newly diagnosed IDA enrolled in the Taiwan National Health Insurance Database from 2000 to 2012. We matched IDA and non-IDA subjects according to age and gender in a 1:2 ratio. Our primary outcome was diagnosis of psychiatric disorders and the patients were monitored until the end of 2013. A multivariate Cox proportional hazards regression model was used to explore the risk of psychiatric disorders in patients with IDA after adjustment for confounders, including demographic characteristics and comorbidities. Results: The adjusted hazard ratios (aHRs) of psychiatric disorders was 1.49 (95% CI = 1.43–1.56) in the IDA group compared with the non-IDA group. Among the different types of psychiatric disorders, the IDA group was associated with significantly higher incidence and risks of dementia, anxiety disorders, depression, sleep disorders, and psychotic disorders ( p < 0.05). Furthermore, iron supplementation in IDA subjects was associated with a significantly lower risk of psychiatric disorders compared to non-iron supplementation in IDA patients. Conclusions: Our study indicates that IDA subjects had an increased risk of psychiatric disorders, regardless of other confounders. In IDA patients, iron supplementation was associated with a decreased risk of psychiatric disorders. Moreover, IDA patients receiving iron supplementation also had a lower risk of sleep disorders.

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“…According to these criteria, anaemia is defined as haemoglobin levels below 13 g/L for men and below 12 g/L for women. In the remaining studies, anaemia was self-reported 25 26 or was defined according to tertiles of haemoglobin status 19 or bisection around the mean. 24…”

Section: Resultsmentioning

confidence: 99%

Association between anaemia and adult depression: a systematic review and meta-analysis of observational studies

Lee

Kim

2020

J Epidemiol Community Health

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BackgroundSeveral observational studies have been conducted to investigate the link between anaemia and adult depression but have shown inconsistent results. This systematic review and meta-analysis was performed to investigate this association.MethodsA comprehensive search of four electronic databases (PubMed, EMBASE, PsycINFO and the Cochrane Library) was conducted to identify relevant papers published up to November 2019 for the systematic review and meta-analysis. The Newcastle-Ottawa Scale was used to assess the methodological quality of selected studies. A random-effects model was used to draw metaestimates of the relationship between anaemia and adult depression.ResultsA total of 9706 papers were retrieved, and 14 observational epidemiological studies (9 case–control studies and 5 prospective cohort studies) comprising 10 764 cases of depression were finally included in this meta-analysis. The mean age of the participants ranged from 38.4 to 75.0 years. A significant association was identified between low haemoglobin levels and adult depression (OR or relative risk 1.43; 95% CI 1.23 to 1.65). Subgroup analyses according to study design, mean age, diagnostic criteria of anaemia, geographical region, number of participants, methodological quality and adjustment for various confounding factors such as education, smoking, comorbid disorders, physical activity, alcohol intake and medication use showed similar results.ConclusionsThe current study showed that anaemia was related to an increased risk of adult depression. One of the important limitations of our study was a moderate degree of heterogeneity due to the variety of assessment tools used to identify depression and the existence of publication bias. Another limitation of this meta-analysis was the lack of prospective cohort studies.

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Association between iron‐deficiency anemia and depression: A web‐based Japanese investigation

Abstract: Self-reported history of iron-deficiency anemia was associated with self-reported history of depression. Furthermore, self-reported history of iron-deficiency anemia was associated with higher psychological distress.

Cited by 67 publications

References 35 publications

Screening of depression in overweight and obese pregnant women and its predictors

Screening of depression in overweight and obese pregnant women and its predictors

Psychiatric disorders risk in patients with iron deficiency anemia and association with iron supplementation medications: a nationwide database analysis

Association between anaemia and adult depression: a systematic review and meta-analysis of observational studies

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