Association between intestinal permeability and faecal microbiota composition in Italian children with beta cell autoimmunity at risk for type 1 diabetes

Maffeis, Claudio; Martina, Alessia; Corradi, Massimiliano; Quarella, Sara; Nori, Nicole; Torriani, Sandra; Plebani, Mario; Contreas, Giovanna; Felis, Giovanna E.

doi:10.1002/dmrr.2790

Cited by 88 publications

(71 citation statements)

References 41 publications

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“…metagenomic relative abundance) coincide with an increase in contributions from P. merdae in the total transcript pool. This behavior is in contrast with that of Dialister invisus : a bacterium predominantly associated with the human oral cavity, which has also been detected in the gut and been implicated in diseases such as IBD and type-1 diabetes 22 , 27 , 28 . While the average DNA abundance of D. invisus was comparable to that of P. merdae , and varied across samples, D. invisus was largely absent from our metatranscriptomic data ( Fig.…”

Section: Resultsmentioning

confidence: 81%

Dynamics of metatranscription in the inflammatory bowel disease gut microbiome

et al. 2018

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Inflammatory bowel disease (IBD) is a group of chronic diseases of the digestive tract affecting millions of people worldwide. Genetic, environmental and microbial factors have been implicated in onset and exacerbation of IBD. However, the mechanisms associating gut microbial dysbioses and aberrant immune responses remain largely unknown. The integrative Human Microbiome Project (iHMP) seeks to close these gaps by examining the dynamics of microbiome functionality in disease by profiling the gut microbiomes of more than 100 individuals sampled over a one year period. Here, we present the first results based on 78 paired fecal metagenomes/metatranscriptomes and 222 additional metagenomes from 59 Crohn’s disease (CD), 34 ulcerative colitis (UC), and 24 non-IBD control patients. We demonstrate several cases in which measures of microbial gene expression in the inflamed gut can be informative relative to metagenomic profiles of functional potential. First, while many microbial organisms exhibited concordant DNA and RNA abundances, we also detected species-specific biases in transcriptional activity, revealing predominant transcription of pathways by individual microbes per host (e.g. by Faecalibacterium prausnitzii). Therefore, a loss of these organisms in disease may have more far-reaching consequences than suggested by their genomic abundances. Further, we identified organisms that were metagenomically abundant but inactive or dormant in the gut with little or no expression (e.g. Dialister invisus). Lastly, certain disease-specific microbial characteristics were more pronounced or only detectable at the transcript level, such as pathways predominantly expressed by different organisms in IBD patients (e.g. Bacteroides vulgatus and Alistipes putredinis). This provides potential insights into gut microbial pathway transcription that can vary over time, inducing phenotypic changes complementary to those linked to metagenomic abundances. The study’s results highlight the strength of analyzing both the activity and presence of gut microbes to provide insight into the role of the microbiome in IBD.

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Section: Resultsmentioning

confidence: 81%

Dynamics of metatranscription in the inflammatory bowel disease gut microbiome

et al. 2018

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“…Maffeis and colleagues chose 10 healthy subjects and 10 children at risk for T1D to participate in a case‐control study to examine the relationship between intestinal permeability and T1D. The results showed that 3 bacteria, including Dialister invisus , Gemella sanguinis , and Bifidobacterium longum, were associated with altered intestinal permeability in T1D . In addition, many other studies revealed that the changes of certain microbes, such as Clostridium perfringens , Dialister invisus , Gemella sanguinis , and Bifidobacterium longum , were related to compromised gut integrity and increased T1D risk .…”

Section: Gut Microbiome and Type 1 Diabetesmentioning

confidence: 96%

“…The results showed that 3 bacteria, including Dialister invisus , Gemella sanguinis , and Bifidobacterium longum, were associated with altered intestinal permeability in T1D . In addition, many other studies revealed that the changes of certain microbes, such as Clostridium perfringens , Dialister invisus , Gemella sanguinis , and Bifidobacterium longum , were related to compromised gut integrity and increased T1D risk . When the intestinal permeability is increased, intestinal toxins, food antigens, and infection factors may translocate from gastrointestinal lumen to intestinal mucosal components, and finally to the pancreatic lymph nodes to induce or exacerbate T1D …”

Section: Gut Microbiome and Type 1 Diabetesmentioning

confidence: 99%

“…The results showed that 3 bacteria, including Dialister invisus, Gemella sanguinis, and Bifidobacterium longum, were associated with altered intestinal permeability in T1D. 57 In addition, many other stud- [206][207][208][209][210][211][212][213][214] , which were functional in vitro and in vivo. 43 These findings illustrate that certain diabetogenic microbes exist in the gut and can induce or speed up the occurrence of T1D through molecular mimicry.…”

Section: Intestinal Permeabilitymentioning

confidence: 99%

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Gut microbiome in type 1 diabetes: A comprehensive review

Zheng

Zhang

2018

Diabetes Metabolism Res

166

126

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SummaryType 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive familial and genome‐wide association studies have revealed more than 50 risk loci in the genome. However, genetic susceptibility cannot explain the increased incidence of T1D worldwide, which is very likely attributed by the growing impact of environmental factors, especially gut microbiome. Recently, the role of gut microbiome in the pathogenesis of T1D has been uncovered by the increasing evidence from both human subjects and animal models, strongly indicating that gut microbiome might be a pivotal hub of T1D‐triggering factors, especially environmental factors. In this review, we summarize the current aetiological and mechanism studies of gut microbiome in T1D. A better understanding of the role of gut microbiome in T1D may provide us with powerful prognostic and therapeutic tools in the near future.

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“…Studies of obese and non-obese diabetic mice have observed that this leads to increased cytokine production that may attack and damage pancreatic β-cells. [57][58][59] Bacterial metabolites may also attack the pancreatic islet directly. This was shown during a study of mice in which Streptomyces-derived toxins impaired glucose tolerance, reducing islet size and β-cell mass at low doses via adenosine triphosphatase inhibition.…”

Section: Mechanistic Linksmentioning

confidence: 99%

Association between Bioactive Molecules in Breast Milk and Type 1 Diabetes Mellitus

Yahaya¹,

Shemishere²

2020

Sultan Qaboos Univ Med J

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The association between breastfeeding and type 1 diabetes mellitus (T1DM) is controversial. However, several recent studies have established a link between these two factors, necessitating a need to review this subject to raise public awareness. Current research indicates that breast milk contains a variety of bioactive substances including immunoglobulins, oligosaccharides, insulin, lactoferrin, lysozyme, cytokines, epidermal growth factors, leukocytes, nucleotides, beneficial bacteria and vitamins. Such substances strengthen the breastfeeding infant’s immune system, both directly, by increasing gut microbiota diversity and attacking harmful bacteria and proinflammatory molecules, and indirectly, by increasing thymus performance. Accordingly, a lack of or inadequate breastfeeding may predispose infants to several autoimmune disorders, including T1DM. Nursing mothers and caregivers are therefore advised to follow optimal breastfeeding practices prior to introducing complementary foods.Keywords: Breastfeeding; Type 1 Diabetes Mellitus; Autoimmune Diseases; Immunoglobulins; Oligosaccharides; Review Literature.

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Association between intestinal permeability and faecal microbiota composition in Italian children with beta cell autoimmunity at risk for type 1 diabetes

Cited by 88 publications

References 41 publications

Dynamics of metatranscription in the inflammatory bowel disease gut microbiome

Dynamics of metatranscription in the inflammatory bowel disease gut microbiome

Gut microbiome in type 1 diabetes: A comprehensive review

Association between Bioactive Molecules in Breast Milk and Type 1 Diabetes Mellitus

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