Association Between Intermediate-Density Lipoprotein Particles and the Progression of Carotid Atherosclerosis: A Community-Based Cohort Study

Liu, Tianxiao; Zhao, Dong; Wang, Miao; Sun, Jiayi; Li, Jun; Li, Jiangtao; Duan, Youling; Hu, Piaopiao; Sun, Zhaoqing; Liu, Jing; Qi, Yue

doi:10.2139/ssrn.4168235

Cited by 1 publication

(1 citation statement)

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“…Thus, the results of Bell et al (11), demonstrating increases in free fatty acids (linoleate, linolenate, palmitoleate, oleate) in the serum, are in agreement with the increased levels of IDL particles. Increased numbers of IDL particles appear to be atherogenic (54). Similarly, plasma samples of patients with non-insulindependent diabetes displayed elevated levels of IDL ApoB, which are potentially atherogenic (55).…”

Section: Frontiers Inmentioning

confidence: 97%

Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis

Fererberger,

Buechler,

Kandulski

et al. 2024

Front. Med.

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IntoductionIdentification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification.MethodsNuclear magnetic resonance (NMR) spectroscopy revealed an altered metabolome and lipidome of 33 patients with PSC [24 patients with inflammatory bowel disease (IBD) and 9 patients without IBD] compared with 40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as well as 64 patients with IBD and other extraintestinal manifestations (EIM) but without PSC.ResultsIn particular, higher concentrations of pyruvic acid and several lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical relevance, a specific amino acid and lipid profile was determined in PSC compared with IBD and other EIM.DiscussionThese results have the potential to improve diagnosis by differentiating PSC patients from HC and those with IBD and EIM.

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Section: Frontiers Inmentioning

confidence: 97%