Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population

Abstract

Objective: To investigate the role of interleukin 6 (IL6) and IL16 single nucleotide polymorphisms (SNPs) in coronary artery disease (CAD) risk in a Chinese population. Methods: Patients with CAD and healthy control subjects were recruited. IL6 (rs1800795 and rs1800796) and IL16 (rs8034928, rs3848180, rs4577037, rs1131445, rs4778889 and rs11556218) genotyping was performed on the MassARRAY Õ platform (Sequenom Õ , San Diego, CA, USA). Results: Frequencies of rs8034928 variant C allele and rs11556218 variant T allele were higher in patients with CAD (n ¼ 326) than controls (n ¼ 341). The rs8034928 C/C genotype (odds ratio [OR] 2.03; 95% confidence intervals [CI] 1.16, 3.62) and C allele (OR 1.97; 95%CI 1.15, 3.45) were associated with increased risk of CAD compared with wild type. Similarly, the rs11556218 T/T genotype (OR 2.44; 95%CI 1.15, 5.44) and T allele (OR 2.37; 95%CI 1.13, 5.24) were associated with increased CAD risk compared with wild type. Conclusion: The SNPs rs8034928 and rs11556218 are associated with CAD risk in the Chinese population, and may be useful predictive markers for CAD susceptibility. KeywordsCoronary artery disease, interleukin 6, interleukin 16, IL6, IL16, polymorphism, predictive markers Date

Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease

“…IL-6 itself is a multifunctional cytokine produced by immune and many non-immune cells, with roles both as an inflammatory mediator and also as a regulator of endocrine and metabolic function. Several studies have found that IL-6 might be involved in the development of CAD (Ghazouani et al, 2011;Phulukdaree et al, 2013;Satti et al, 2013;Tong et al, 2013), but the results have been inconsistent. Therefore, we conducted a case-control study to investigate the relationship between the two common polymorphisms of the IL-6 gene and CAD, in order to gain a more reliable conclusion.…”

“…Another recent study conducted by Phulukdaree et al (2013) reported that the IL-6 -174G allele influenced the levels of IL-6 and the risk of CAD in South African Indians. However, two additional studies reported conflicting results (Ghazouani et al, 2011;Tong et al, 2013). Ghazouani et al (2011) and Tong et al (2013) reported that the IL-6 -174 G>C variant was not correlated with an increased risk of CAD in Tunisians or in a Chinese population, respectively.…”

“…However, two additional studies reported conflicting results (Ghazouani et al, 2011;Tong et al, 2013). Ghazouani et al (2011) and Tong et al (2013) reported that the IL-6 -174 G>C variant was not correlated with an increased risk of CAD in Tunisians or in a Chinese population, respectively. However, a recent meta-analysis of 50 studies suggested that the IL-6 -174 G>C polymorphism was positively associated with susceptibility to CAD (Yin et al, 2013), which is in line with the results of our study.…”

IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease

“…IL-6 plays an important role in mediating inflammatory and regular metabolism (Bowcock et al, 1988). Several studies have reported the association between IL-6-174G/C and IL-6-572C/G gene polymorphisms and the risk of CAD (Jang et al, 2008;Phulukdaree et al, 2013;Tong et al, 2013;Elsaid et al, 2014). Phulukdaree et al (2013) reported that the presence of the IL-6-174G allele influences levels of IL-6 and increases the risk of CAD in South African Indians.…”

The Role of Interleukin-6 Gene in Development of Idiopathic Sick Sinus Syndrome

“…Так, при исследованиях, проводимых среди лиц ази-атской популяции, было установлено, что полимор-физмы 174G/C, С572G, ОНП rs8034928 и rs11556218 гена IL-6 статистически значимо связаны с повы-шенным риском ИБС [5][6][7][8]. Учеными из Мексики во главе с Fragoso JM, et al в 2015г выявлена ассоци-ация полиморфизмов rs1800796 и rs2069827 гена IL-6 с развитием рестенозов коронарных артерий у мекси-канских пациентов [9].…”