Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population

Abstract

Objective:Emerging evidence suggests that interleukin 37 (IL-37) plays an important role in the pathogenesis of several autoimmune diseases (ADs), but the correlations are still unclear. We conducted a meta-analysis to explore whether IL-37 gene (rs3811047) polymorphism was associated with susceptibility to multiple ADs in a Chinese population.Methods:Relevant studies were searched in the PubMed, Embase, Chinese National Knowledge Infrastructure, and Chinese Wangfang databases up to August 31, 2017. Odds ratio (OR) and its 95% confidence interval (95% CI) was used to estimate the strength of the association in different genetic models. The results of fixed or random models were adopted according to the heterogeneity. Publication bias and sensitive analysis were also performed to evaluate the reliability of results.Results:A total of 3161 patients and 4078 controls from 6 studies were included in this meta-analysis. Pooling all data together, a significant association between IL-37 gene (rs3811047 A/G) polymorphism and susceptibility to ADs in the Chinese population was found in all 4 genetic models (allelic model A vs G: OR = 0.73 95% CI = 0.67∼0.79; recessive model AA + AG vs GG: OR = 0.72, 95% CI = 0.65∼0.79; dominant model AA vs AG + GG: OR = 0.59, 95% CI = 0.45∼0.77; homozygous model AA vs GG: OR = 0.55, 95% CI = 0.42∼0.72). No heterogeneity and publication bias was detected in all models. Sensitive analysis indicated that all of the positive results are reliable.Conclusion:The IL- 37 (rs3811047) polymorphism contributes to the development of ADs in a Chinese population.

Correlation analysis of IL‐37 gene polymorphisms and susceptibility to chronic HBV infection among Han people in Central China

“…This study is the first to discuss the relationship between this locus and susceptibility to chronic HBV infection in the Chinese Han population, and we also did not obtain statistically significant results. However, evidence suggests that rs3811047 is associated with susceptibility to PU, ankylosing spondylitis, RA, autoimmune thyroid diseases and Behcet's disease (Davarpanah et al., 2020; Lin et al., 2018; Özgüçlü et al., 2019; Tan et al., 2016). Interestingly, a similar study found a significant association between the two SNPs and susceptibility to COVID‐19 among Iraqi patients (Ahmed & Ad'hiah, 2022).…”

Interleukin-37: associations of plasma levels and genetic variants in gout

“…Variant rs3811047 has been associated with susceptibility to or protection against several infectious, inflammatory, and autoimmune diseases as ankylosing spondylitis, rheumatoid arthritis, auto-immune thyroid disease, Behcet’s disease, and Vogt-Koyanagi-Harada disease [ 28 ]. The current study showed that TG genotype of rs3811046 may increase the risk of developing COVID-19 [ 21 ].…”

Interleukin-37 gene polymorphism and susceptibility to coronavirus disease 19 among Iraqi patients

“…Studies have highlighted this variant more than rs3811046. This SNP has been associated with susceptibility to or protection against several infectious, inflammatory and autoimmune diseases (Al-Anazi et al, 2019;Allam et al, 2016;Lin et al, 2018;Offenbacher et al, 2018;Özgüçlü et al, 2019). Tuberculosis is the only infectious disease of the respiratory tract studied and susceptibility to disease was not associated with rs3811047, but C allele and CC genotype of another IL37 gene SNP (rs2723176) occurred significantly more frequently in patients with active tuberculosis (Allam et al, 2016).…”

“…With respect to inflammatory and autoimmune diseases, G allele and GG genotype of rs3811047 SNP showed significantly increased frequencies in Chinese patients with Behcet's disease in comparison with controls (Tan et al, 2016), but these findings were not confirmed in Turkish patients, and Behcet's disease did not show association with rs3811047 ( Özgüçlü et al, 2019). A meta-analysis of multiple autoimmune diseases in Chinese patients (ankylosing spondylitis, rheumatoid arthritis, autoimmune thyroid disease, Behcet's disease and Vogt-Koyanagi-Harada disease) revealed a significant association between rs3811047 variant and susceptibility to autoimmune diseases in four genetic models (allele, recessive, dominant and heterozygous) (Lin et al, 2018). In ankylosing spondylitis patients, it was interesting to note that expressions of Creactive protein and erythrocyte sedimentation rate (inflammatory markers) were influenced by GG genotype of rs3811047 (Chen et al, 2011).…”

“…IL37 gene (Gene ID: 27178) is mapped to the long arm of human chromosome 2 (2q14.1), spans 3.617 kb and consists of seven exons (www.ncbi.nlm.nih.gov/gene/27178). The gene harbors many single nucleotide polymorphisms (SNPs), and genetic association studies have linked some of these SNPs with susceptibility to several autoimmune, inflammatory and infectious diseases (for instance, Behçet disease, systemic lupus erythematosus, periodontal inflammation, hepatitis viral infection and tuberculosis) (Al-Anazi et al, 2019;Allam et al, 2016;Lin et al, 2018;Offenbacher et al, 2018;Özgüçlü et al, 2019). Of particular interest is the exon SNP rs3811047, and some of these studies have suggested a role for this variant in the risk of various human diseases.…”