Association Between Interleukin-3 Gene Polymorphism and Acute Rejection After Kidney Transplantation

Lee, D.-Y.; Song, Seung‐Dal; Moon, Ju Young; Jeong, Kyung Hwan; Park, S.J.; Kim, H.-J.; Kang, Sun Woo; Lee, S.-H.; Kim, Y.-H.; Chung, Joo Ho; Ihm, Chun Gyoo; Lee, T.-W.

doi:10.1016/j.transproceed.2010.09.153

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…Our study showed that in CYP3A5 non-expressers, the IL-3 rs181781 AA genotype showed higher TAC logC0/Ds than the AG genotypes at 30 and 90 d (P=0.004 and P=0.033, respectively), and the GG genotypes at 30 d (P=0.011) post-transplantation ( Figure 2). As reported by Lee et al, in the promoter SNP rs181781 site, 3 transcription factors (Sp1, SRF, and HNF2C) bind to the A-containing sequence, whereas only 1 (SP1) binds to the G-containing sequence; therefore, it is likely that rs181781 may influence the expression of IL-3 by influencing transcription factor binding [27] . Considering the role of IL-3 in the immune system, differences in the expression of IL-3 may influence the tacrolimus dose requirements.…”

Section: Discussionmentioning

confidence: 82%

“…Previous studies have demonstrated that a promoter SNP of IL-3, rs181781, is associated with acute rejection (AR) after kidney transplantation [27] . Our study showed that in CYP3A5 non-expressers, the IL-3 rs181781 AA genotype showed higher TAC logC0/Ds than the AG genotypes at 30 and 90 d (P=0.004 and P=0.033, respectively), and the GG genotypes at 30 d (P=0.011) post-transplantation ( Figure 2).…”

Section: Discussionmentioning

confidence: 99%

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IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients

Liu

Zhang

et al. 2017

Acta Pharmacol Sin

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The highly variable pharmacokinetics and narrow therapeutic window of tacrolimus (TAC) has hampered its clinical use. Genetic polymorphisms may contribute to the variable response, but the evidence is not compelling, and the explanation is unclear. In this study we attempted to find previously unknown genetic factors that may influence the TAC dose requirements. The association of 105 pathway-related single nucleotide polymorphisms (SNPs) with TAC dose-adjusted concentrations (C0/D) was examined at 7, 30 and 90 d post-operation in 382 Chinese kidney transplant recipients. In CYP3A5 non-expressers, the patients carrying the IL-3 rs181781 AA genotype showed a significantly higher TAC logC0/D than those with the AG genotype at 30 and 90 d post-operation (AA vs AG, 2.21±0.06 vs 2.01±0.03, P=0.004; and 2.17±0.06 vs 2.03±0.03, P=0.033, respectively), and than those with the GG genotype at 30 d (AA vs GG, 2.21±0.06 vs 2.04±0.03, P=0.011). At 30 d, the TAC logC0/D in the grouped AG+GG genotypes of CTLA4 rs4553808 was significantly lower than that in the AA genotype (P=0.041) in CYP3A5 expressers, but it was higher (P=0.008) in the non-expressers. We further validated the influence of CYP3A5 rs776746, CYP3A4 rs2242480 and rs4646437 on the TAC C0/D; other candidate SNPs were not associated with the differences in TAC C0/D. In conclusion, genetic polymorphisms in the immune genes IL-3 rs181781 and CTLA4 rs4553808 may influence the TAC C0/D. They may, together with CYP3A5 rs776746, CYP3A4 rs2242480 and rs4646437, contribute to the variation in TAC dose requirements. When conducting individualized therapy with tacrolimus, these genetic factors should be taken into account.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients

Liu

Zhang

et al. 2017

Acta Pharmacol Sin

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“…IL-3 is a haematopoiesis promoting factor and aids in embryo implantation and placental development, whose maternal serum level increases as a function of the trimester [9]. IL-3 gene polymorphisms were associated with acute rejection after kidney transplantation [10]. IL-6 plays a role in reproduction and immune balance, acting as a multifunctional cytokine with anti- and pro-inflammatory response and regulates the behaviour of the gestational tissues [11].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles

Lee

Yang

et al. 2019

IJERPH

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The aim of this study was to examine the association between interleukin (IL) genes polymorphisms and in vitro fertilization (IVF) outcome. A prospective cohort analysis was performed at a Women’s Hospital IVF centre of 1015 female patients undergoing fresh non-donor IVF cycles. The effects of the following six single nucleotide polymorphisms (SNPs) in five IL genes on IVF outcomes were explored: IL-1α (rs1800587 C/T), IL-3 (rs40401 C/T), IL-6 (rs1800795 C/G), IL-15 (rs3806798 A/T), IL-18 (rs187238 C/G) and IL-18 (rs1946518 G/T). The main outcome measures included clinical pregnancy, embryo implantation, abortion and live birth rates. There were no statistically significant differences in clinical pregnancy, embryo implantation and live birth rates in the analysis of 1015 patients attempting their first cycle of IVF. Infertile women with IL-3 homozygous major genotype had a higher abortion rate than those with heterozygous and homozygous minor genotype (16.5% vs. 7.9%, P = 0.025). In conclusion, our results indicated that the IL-3 rs40401 polymorphism is associated with increased risk of abortion of IVF patients. Future studies with inclusion of other ethnic populations must be conducted to confirm the findings of this study.

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“…In the past years, many researches have focused on the improvement of protective layer such as a doped MgO layer, 5-8 a double protective layer, [9][10][11] and new materials instead of MgO protective layer. [12][13][14] Recently, our group has investigated the discharge characteristics of electron-beam evaporated LaB 6 thin film coated on a dielectric layer.…”

Section: Introductionmentioning

confidence: 99%

Lowering of the firing voltage and reducing of the discharge delay time in alternating current plasma display panels by a discontinuous spin-coated LaB6 film on the MgO protective layer

et al. 2014

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A spin coated LaB6 discontinuous film is covered on MgO protective layer to improve the discharge performance of alternating current plasma display panels. Under the premise of high transmittance of more than 90%, a very small amount of polycrystal LaB6 powders added in an organic solvent are chosen as the coating solution. The discharge characteristics results show that with 250 torr 5% Xe-Ne pressure, the firing voltage and discharge delay time of the test panel with LaB6/MgO double protective layer are decreased by 13.4% and 36.5%, respectively, compared with that of conventional MgO protective layer, likely owing to the low work function of LaB6. Furthermore, the aging time of the proposed structure is comparable to that of pure MgO protective layer. Therefore, it will not increase the production costs and is highly suitable to be applied for alternating current plasma display panels with low electrical power consumption.

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Association Between Interleukin-3 Gene Polymorphism and Acute Rejection After Kidney Transplantation

Cited by 13 publications

References 15 publications

IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients

IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients

Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles

Lowering of the firing voltage and reducing of the discharge delay time in alternating current plasma display panels by a discontinuous spin-coated LaB6 film on the MgO protective layer

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