Association between interleukin‐18 gene polymorphism 105A/C and asthma

SummarySystemic lupus erythematosus (SLE) is a multisystem autoimmune connective tissue disorder characterized by various aberrations including increased production of IL-18.Since IL-18 105 A>C polymorphic variants have been linked to increased production of this cytokine, we investigated the prevalence of IL-18 105 A>C (rs549908) polymorphic variants in SLE patients (n=111) and controls (n=152).There were no significant differences in the distribution of IL-18 105 A>C polymorphic variants in SLE patients and controls. However, there was a significant association between the IL-18 105 AA genotype (recessive model) and renal manifestations OR=3.360 (1.523-7.415, P=0.0039) and the P value remained statistically significant after Bonferroni correction (P corr = 0.0351).Our findings indicate that the IL-18 105 AA genotype variant can contribute to renal manifestations in patients with SLE.

show abstract

“…Higa et al (2003) found that the frequency of the 105A allele was significantly higher in asthmatic patients than in controls [33].…”

Section: Discussionmentioning

confidence: 99%

“…Investigation has revealed the relationship between IL-18 gene polymorphic variants and predisposition to various malignant viral and autoimmune diseases [22][23][24][25][26][27][28][29][30][31][32][33]. Recently, a significant association was found between SLE and the IL-18 105 A>C (rs549908) polymorphic variants [32].…”

Section: Introductionmentioning

confidence: 99%

IL-18 105 A>C polymorphism contributes to renal manifestations in patients with SLE

et al. 2009

View full text Add to dashboard Cite

show abstract

“…In order to determine whether this difference was due to genetic factors, the þ 105 A4C SNP was genotyped throughout the cohort. 23 The frequency of the A allele for patients with asthma was 0.89, significantly higher than that for controls (0.82) (Po0.01). The odds ratio (OR) of carrying one of the two A alleles vs none was calculated as 1.83 (1.37-2.26).…”

mentioning

confidence: 82%

“…Despite various associations showing that it may be important in asthma (see section Asthma), the SNP was not shown to be associated with differences in plasma IL-18 levels. 23 However, studies using monocytes isolated from healthy volunteers show A þ 105C may have an effect on IL18 transcription in vitro. Unstimulated monocytes with þ 105 AA genotype showed significantly higher IL-18 production, than those with þ 105 AC genotype.…”

Section: Methods Of Actionmentioning

confidence: 99%

“…The frequency of Arg allele for patients with asthma was similar to that from controls. 23 In an attempt to repeat the above findings, Shin et al 65 genotyped a number of polymorphisms in a Korean asthma cohort. Although no polymorphism showed a significant association with the risk of asthma development, analyses of associations with specific serum immunoglobulin E (IgE) levels to Dermatophagoides farinae and D. pteronyssinus (common aeroallergens) revealed significant associations with þ 105.…”

mentioning

confidence: 97%

See 1 more Smart Citation

Interleukin-18 genetics and inflammatory disease susceptibility

Thompson¹,

Humphries²

2007

Genes Immun

View full text Add to dashboard Cite

IL18 was mapped to 11q22.2-22.3 in 1998. Owing to interleukin (IL)-18's important and novel role in immunomodulation, the gene itself has been subject to scrutiny, with the aim of discovering variants that may impact on disease susceptibility and/or progression. Despite being sequenced numerous times in different populations, no non-synonymous variants have been found. However, a number of polymorphisms within the proximal promoter have been verified that may interfere with transcriptionfactor-binding sites. Much of the subsequent association analyses have centred on these variants, but have yielded no consistent results, despite numerous different study populations being genotyped. IL18 has recently been resequenced in its entirety, enabling the tagging-single-nucleotide polymorphism (tSNP) methodology to be adopted. This approach has yielded interesting results, with genetic variation being shown to affect protein levels, and risk. This review aims to compile and reflect on the association data of interest published to date, with a focus on the diseases related to aberrant inflammatory control. Genes and Immunity (2007) 8, 91-99.

show abstract