Association between interferon-induced helicase (IFIH1 ) rs1990760 polymorphism and seasonal variation in the onset of type 1 diabetes mellitus

Abstract

The IFIH1 rs1990760 polymorphism seems to be associated with the seasonal manifestation of T1DM. Our findings suggest that this virus receptor gene may contribute to T1DM manifestation primarily in the summer period.

Genetic Association Study of IL2RA, IFIH1, and CTLA-4 Polymorphisms With Autoimmune Thyroid Diseases and Type 1 Diabetes

“…Genetic association between IFIH1 polymorphism and T1D development might be explained by the link of the disease with prior viral infection. Moreover, Jermedy et al found in their work that there is a seasonal manifestation of T1D was related to rs1990760 polymorphism as the AA genotype, that predisposes to the disease, was more frequent in patients who developed the disease in summer than in patients with onset in winter indicating that this virus receptor gene might influence T1D manifestation mainly during the summer months (59).…”

Screening key genes and signaling pathways in COVID-19 infection and its associated complications by integrated bioinformatics analysis

“…CXCL10 [76], SIGLEC1 [77] and IL1R2 [78] have been suggested to be associated with neurological diseases. CXCL9 [79], SIGLEC1 [80], IL1R2 [81], KLF15 [82] and CD207 [83] [146], STAT4 [147], CXCL8 [148], KLF2 [149], ADM (adrenomedullin) [150], EGR1 [151], TRIB1 [152], SOD2 [153], OXSR1 [154], IL6R [155], CD44 [156], LRG1 [157], PFKFB2 [158], PACSIN2 [159], MYH9 [160], DOT1L [161], CXCL16 [162], PTEN (phosphatase and tensin homolog) [163], FOXO3 [164], DDIT4 [165], PINK1 [166], IQGAP1 [167], ADIPOR1 [168], MTMR3 [169], USF2 [170], SGK1 [171], GSTO2 [172], ETS2 [173], TKT (transketolase) [174], CMIP (c-Maf inducing protein) [175], THBD (granzyme A) [464], IFNG (interferon gamma) [465], IFIH1 [466], STAT1 [467], CCR5 [468], ADCY5 [469], MT2A [470], DPP4 [471], FASLG (Fas ligand)…”

“…In the present investigation, a total of 738 DEGs between COVID-19 samples and non COVID-19 samples were identified, consisting of 415 [76], SIGLEC1 [77] and IL1R2 [78] have been suggested to be associated with neurological diseases. CXCL9 [79], SIGLEC1 [80], IL1R2 [81], KLF15 [82] and CD207 [83] [146], STAT4 [147], CXCL8 [148], KLF2 [149], ADM (adrenomedullin) [150], EGR1 [151], TRIB1 [152], SOD2 [153] [162], PTEN (phosphatase and tensin homolog) [163], FOXO3 [164], DDIT4 [165], PINK1 [166], IQGAP1 [167], ADIPOR1 [168], MTMR3 [169] [464], IFNG (interferon gamma) [465], IFIH1 [466], STAT1 [467], CCR5 [468], ADCY5 [469], MT2A [470], DPP4 [471], FASLG (Fas ligand) [472], HLA-DMB [473], CD3D [474], CMKLR1 [475], ICOS (inducible T cell costimulator) [476] [492], CFB (complement factor B) [493], TLR7 [494], SLAMF1 [495], BPIFA1 [496], CD300E [497], TAP2 [498], CD48 [499], APOL1 [500], BACH2 [501], CD226 [502], CXCL12…”

Advances in Knowledge of Candidate Genes Acting at the Beta-Cell Level in the Pathogenesis of T1DM

“…Additionally, several studies showed that the IFIH1 A946T risk allele exerts its effect via the IFNβ-mediated response rather than through IFN-α, and IFN-β can promote persistent LCMV (lymphocytic choriomeningitis virus) infection, which causes enduring beta-cell damage (61)(62)(63)(64)(65). Intriguingly, a previous study indicated an association between the SNP rs1990760 and seasonal variation in the onset of T1DM and found that the predisposing gene was more likely to be associated with the onset of T1DM in summer (66). This finding may be explained by the theory that T1DM is caused by environmental factors in individuals with a genetically susceptible background.…”