Association Between Insulin Resistance Estimated by Triglyceride Glucose Index and In-Stent Restenosis in Non-Diabetic Patients

Ferik, Özge Kurmuş; Sayin, Begum Yetis; Akbuğa, Kürşat; Zorlu, Çağrı

doi:10.32596/ejcm.galenos.2022.2021-11-060

Cited by 3 publications

(5 citation statements)

References 21 publications

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“…In the two studies focusing on CCS patients, the combined results showed that for each unit increase in the TyG index, the risk of ISR in patients increased by 37% (95% CI 1.19-1.57, I²=0%, p < 0.005, Fig. 3) [9,20]. A similar trend was observed in studies focusing on ACS patients (OR:1.48, 95% CI 1.19-1.85, I²=0, p < 0.005, Fig.…”

Section: Tyg Index and Isr In Ccs And Acs Patinentsmentioning

confidence: 94%

“…Five observational studies, comprising 3,912 participants who had previously undergone stent implantation and had no ISR at baseline, were included. Among these studies, three were conducted in China [10,19,20] and two in Turkey [9,21]. Participants' ages ranged from 56 to 63 Fig.…”

Section: Study Characteristics and Quality Assessmentmentioning

confidence: 99%

“…1 Flow diagram of study selection years, with male proportions varying from 60 to 80% and diabetes prevalence between 0% and 50%. All five studies analyzed the TyG index as a continuous variable [9,10,[19][20][21], with two additionally treating it as a categorical variable [19,20]. All the studies conducted adjustments for confounding factors (Tables 1 and 2).…”

Section: Study Characteristics and Quality Assessmentmentioning

confidence: 99%

“…Analysis of data from five studies showed that, in the context of CHD patients, each incremental unit in the TyG index, when treated as a continuous variable, corresponded to a 42% elevation in ISR risk (OR 1.42, 95% CI 1.26-1.59, I²=13%, p < 0.005, Fig. 2a) [9,10,[19][20][21]. Moreover, in studies where the TyG index was categorized, results indicated a significantly higher risk of ISR in CHD patients with the highest TyG index compared to those with the lowest TyG index (OR: 1.69, 95% CI 1.32-2.17, I²=0, Fig.…”

Section: Tyg Index and Isr In Chd Patientsmentioning

confidence: 99%

“…Observational studies also suggested a higher propensity for ISR in CHD patients with elevated TyG index levels. However, some of these studies have limitations due to their small sample sizes [9,10]. Therefore, this meta-analysis aimed to overcome these limitations by combining sample sizes and thereby enhancing the overall test efficacy to explore the TyG index-ISR relationship.…”

Section: Introductionmentioning

confidence: 99%

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The association between the triglyceride-glucose index and in-stent restenosis in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Jiang,

liu,

Guo

et al. 2024

BMC Cardiovasc Disord

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Background Insulin resistance (IR) can lead to cellular metabolic disorders, activation of oxidative stress, and endothelial dysfunction, contributing to in-stent restenosis (ISR). The triglyceride-glucose index (TyG index), a new indicator reflecting IR, is extensively researched in the cardiovascular field. This study, through a meta-analysis, aimed to utilize a larger combined sample size and thereby enhance the overall test efficacy to explore the TyG index-ISR relationship. Methods A thorough search was conducted in the PubMed, EMBASE, Web of Science, and Cochrane Library databases to find original papers and their references published between 1990 and January 2024. This search included both prospective and retrospective studies detailing the correlation between the TyG index and ISR in individuals with coronary heart disease (CHD). Outcomes The five included articles comprised 3,912 participants, and the odds ratio (OR) extracted from each study was combined using the Inverse Variance method. Results showed that, in the context of CHD patients, each incremental unit in the TyG index, when treated as a continuous variable, corresponded to a 42% elevation in ISR risk (95% CI 1.26–1.59, I²=13%, p < 0.005). When analyzing the TyG index categorically, the results revealed a higher ISR risk in the highest TyG index group compared to the lowest group (OR: 1.69, 95% CI 1.32–2.17, I²=0). Additionally, in patients with chronic coronary syndrome (CCS), each unit increase in the TyG index, the risk of ISR in patients increased by 37% (95% CI 1.19–1.57, I²=0%, p < 0.005). This correlation was also observable in acute coronary syndrome (ACS) patients (OR:1.48, 95% CI 1.19–1.85, I²=0, p < 0.005). Conclusions The TyG index, an economical and precise surrogate for IR, is significantly linked with ISR. Furthermore, this correlation is unaffected by the type of coronary heart disease.

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Section: Tyg Index and Isr In Ccs And Acs Patinentsmentioning

confidence: 94%

Section: Study Characteristics and Quality Assessmentmentioning

confidence: 99%

Section: Study Characteristics and Quality Assessmentmentioning

confidence: 99%

Section: Tyg Index and Isr In Chd Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The association between the triglyceride-glucose index and in-stent restenosis in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Jiang,

liu,

Guo

et al. 2024

BMC Cardiovasc Disord

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Triglyceride–Glucose Index as a Predictor of Major Adverse Cardiovascular Events in Post-PCI Patients Diagnosed with In-Stent Restenosis

Wang,

Kong,

Tao

et al. 2024

DMSO

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The impact of triglyceride-glucose index on the prognosis of post-PCI patients–a meta-analysis

Wang,

Kong,

Tao

et al. 2024

Front. Cardiovasc. Med.

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BackgroundPrevious research has demonstrated the validity of the triglyceride-glucose (TyG) index as a robust measure of insulin resistance (IR) and its association with coronary artery disease (CAD). The objective of this study is to elucidate the relationship between the TyG index and the prognosis of patients underwent percutaneous coronary intervention (PCI) through a comprehensive systematic review and meta-analysis. Our goal is to provide a thorough analysis of the available evidence to offer more clarity on this association.MethodsA systematic and thorough search was carried out in the PubMed, Embase, Cochrane Library, and Web of Science databases, covering studies published in English from the beginning until October 1, 2023. The focus of the search was to gather relevant studies pertaining to the occurrence of major adverse cardiovascular events (MACE). To address the variability among the included studies, random or fixed effect models were utilized to summarize the hazard ratios (HR). In cases where heterogeneity was detected, subgroup or sensitivity analyses were performed to explore potential sources. To evaluate publication bias, the Egger or Begg test was employed.ResultsThis study incorporated a total of 17 studies. Individuals with the highest TyG index exhibited an elevated risk of major adverse cardiovascular events (MACEs) compared to those with the lowest TyG index (HR = 1.69; 95% CI: 1.47–1.95; P < 0.001). When analyzing the TyG index as a continuous variable, each standard deviation increase was associated with an HR of 1.60 (95% CI: 1.48–1.73; P < 0.001). Moreover, in patients diagnosed with acute coronary syndrome (ACS), higher TyG index levels showed a trend of increased risk of MACE (HR = 1.54; 95% CI: 1.27–1.86; P < 0.001). Furthermore, an elevated TyG index was found to be associated with a higher risk of in-stent restenosis (HR = 1.62; 95% CI: 1.29–2.03; P < 0.001), new-onset atrial fibrillation (HR = 2.97; 95% CI: 2.10–4.06; P = 0.014), and a reduction in quantitative flow ratio (HR = 1.35; 95% CI: 1.101–1.592; P = 0.005). Subgroup analysis indicated the risk of MACE was comparable between varied durations of follow-up (P = 0.11). Furthermore, regression analysis revealed that the positive association between TyG index and the risk of MACE did not differ between individuals with or without diabetes (P = 0.23).ConclusionAn increase in the TyG index may lead to a higher vulnerability to major adverse cardiovascular events (MACE) in patients underwent PCI and there was no significant difference in the risk of major adverse cardiovascular events (MACE) between diabetic and non-diabetic individuals.

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Association Between Insulin Resistance Estimated by Triglyceride Glucose Index and In-Stent Restenosis in Non-Diabetic Patients

Cited by 3 publications

References 21 publications

The association between the triglyceride-glucose index and in-stent restenosis in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

The association between the triglyceride-glucose index and in-stent restenosis in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Triglyceride–Glucose Index as a Predictor of Major Adverse Cardiovascular Events in Post-PCI Patients Diagnosed with In-Stent Restenosis

The impact of triglyceride-glucose index on the prognosis of post-PCI patients–a meta-analysis

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