Association between insulin resistance and apolipoprotein B in normoglycemic Koreans

Sung, Ki Chul; Hwang, Sang Tai

doi:10.1016/j.atherosclerosis.2004.11.009

Cited by 31 publications

(19 citation statements)

References 20 publications

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“…Despite considerably lower LDLcholesterol values, the median apo B level of 109 mg/dl is comparable to that of other populations. 19 Insulin resistance, reported to be an independent predictor of apo B in normoglycaemic Koreans, 20 appeared to be a weaker independent determinant of apo B levels in our population sample.…”

Section: Discussionmentioning

confidence: 67%

“…With increasing number of ATP III criteria of MS and HOMA index, progressively higher concentrations of apo B were observed in normoglycemic Koreans. 20 Yet, as far as we could ascertain, prospective studies on prediction of these conditions by apo B were lacking, in contrast to the high number of papers that analyzed the predictive value of apo B in relation to CHD or cardiovascular disease. 8,21 The current study documents for the first time such predictive capability of apo B levels, not only for an isolated component of MS, but conjointly for atherogenic dyslipidemia, MS itself in the same cohort and, as concerns women, for hypertension and diabetes.…”

Section: Magnitude Of Associationsmentioning

confidence: 99%

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Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation

et al. 2007

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Objectives: To investigate the role of serum apolipoprotein (apo) B levels in predicting metabolic syndrome (MS), hypertension, atherogenic dyslipidemia and type II diabetes. Methods: Prospective evaluation of 1125 men and 1223 women, aged 28-74 years, participating in the survey 1997/1998 who had serum apo B determinations and were followed-up for a mean 5.9 years. Tertiles of apo B were formed by cut points by 120 and 95 mg/dl. MS was defined by modified ATPIII criteria. Results: Apo B values exhibited no significant difference among sexes. Low-density lipoprotein (LDL)-cholesterol and triglycerides were their leading determinants on linear regression analysis. By logistic regression analyses, the top versus bottom apo B tertile predicted significantly newly developing MS in both sexes separately with two-fold relative risks (RRs) (Po0.02) and the development of high triglyceride/low high-density lipoprotein-cholesterol dyslipidemia with nearly threefold RRs (P ¼ 0.001), after adjustment for waist circumference, C-reactive protein (CRP), physical activity grade and family income category. Development of hypertension was predicted only in women by the apo B top tertile (fully adjusted RR 1.71 [95% CI 1.001; 2.92]), while the significance of the prediction regarding age-adjusted diabetes in women (RR 1.86 [95% CI 1.04; 3.36]) attenuated after adjustment for the stated confounding factors. Conclusions: Apo B concentrations, which reflect the number of small, dense LDL particles in plasma, are a significant predictor of cardiometabolic risk among adults with a high prevalence of MS, independent of waist circumference and CRP.

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Section: Discussionmentioning

confidence: 67%

Section: Magnitude Of Associationsmentioning

confidence: 99%

Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation

et al. 2007

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“…33,34 Total cholesterol, high-density lipoprotein (HDL), and triglycerides (TGs) were measured on the Bayer Advia 1650 Autoanalyzer using standard reagents. 35,36 Total cholesterol was measured using a method based on an enzymatic assay using cholesterol ester hydrolase and cholesterol oxidase conversion followed by a colorimetric Trinder end point reaction. HDL-cholesterol (HDL-C) plasma concentrations were measured using the direct HDL-C method in serum and plasma without prior separation.…”

Section: Laboratory Measurementmentioning

confidence: 99%

Association Between Leukocyte Telomere Length and Plasma Homocysteine in a Singapore Chinese Population

Rane

Koh

Kanchi

et al. 2015

Rejuvenation Research

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Rationale: Leukocyte telomere length (LTL) and plasma homocysteine (HCY) have been independently associated with cardiovascular disease (CVD) morbidity and mortality. However, few studies have investigated the association between LTL and HCY levels. Objective: This study investigated the association of LTL with CVD risk factors, including HCY, in an overt CVD-free Singapore Chinese population comprised of middle aged and elderly, the age group at risk of developing CVD. Approach: The association of plasma HCY and other CVD biomarkers with LTL were assessed in 100 samples drawn from the Singapore Chinese Health Study (SCHS). SCHS, a population-based cohort, recruited Chinese individuals, aged 45-74 years, between 1993 and 1998. Questionnaire data were collected via face-to-face interviews. Known CVD biomarkers were measured from the blood collected at the time of recruitment, and LTL was measured using the conventional Southern blot method. Results: After adjustment for age, gender, smoking status, education, and dialect, LTL was found to be inversely associated with plasma HCY levels ( p for trend = 0.014). Serum urate showed a weak association ( p for trend = 0.056). Other CVD risk factors and nutrients, namely total cholesterol, low-density lipoprotein (LDL), triglycerides and creatinine, high-density lipoprotein (HDL), folate, and vitamin B6 showed the expected trend with LTL, but did not reach statistical significance. Conclusion: LTL displayed an inverse association with plasma HCY. This LTL-HCY inverse association in subjects lacking obvious cardiovascular events suggests that telomere length may be an intermediary in the biological mechanism by which elevated HCY leads to CVD.

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“…11,22,23 Although LDL particle numbers cannot be directly assessed by gel electrophoresis, apoB does provide a measure of combined LDL and triglyceride-rich lipoprotein (mainly VLDL) particle numbers 24 and is a good surrogate measure for increased LDL particle numbers in people with diabetic dyslipidemia 24 as well as with the MetSyn and insulin resistance. 25,26 …”

Section: Previous Studiesmentioning

confidence: 99%

Increased Small Low-Density Lipoprotein Particle Number

Kathiresan

Otvos²,

Sullivan³

et al. 2006

Circulation

270

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Background-Levels of LDL cholesterol (LDL-C) are frequently not elevated in individuals with the metabolic syndrome (MetSyn). However, the atherogenic potential of LDL may depend on the number and size of LDL particles in addition to the cholesterol content of LDL. Methods and Results-We examined the sex-specific cross-sectional relations of small LDL particle number (determined by nuclear magnetic resonance spectroscopy) to the presence of MetSyn and its components in 2993 Framingham Heart Study participants (mean age, 51 years; 53% women) without cardiovascular disease (CVD) and the relations of small LDL particle number to CVD incidence in people with MetSyn. The MetSyn (Ն3 of 5 traits as defined by the National Cholesterol Education Adult Treatment Panel III) was present in 27% of men and 17% of women. In both sexes, small LDL particle number increased from 0 to 5 MetSyn traits, a pattern partly accounted for by strong correlations between small LDL particle number and serum triglycerides (rϭ0.61, PϽ0.0001) and HDL-C (rϭϪ0.55, PϽ0.0001). Compared with participants without the MetSyn, those with the MetSyn had a higher CVD event rate. However, among participants with the MetSyn, CVD rates were similar for groups with an elevated versus a lower number of small LDL particles (defined by the sex-specific median). Conclusions-Small LDL particle number is elevated in the MetSyn, increases with the number of MetSyn components, and most prominently is correlated with triglycerides and HDL-C. Whereas increased small LDL particle number identified the MetSyn with high sensitivity, a higher small LDL particle number was not associated with greater CVD event rates in people with the MetSyn.

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Association between insulin resistance and apolipoprotein B in normoglycemic Koreans

Cited by 31 publications

References 20 publications

Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation

Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation

Association Between Leukocyte Telomere Length and Plasma Homocysteine in a Singapore Chinese Population

Increased Small Low-Density Lipoprotein Particle Number

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