Association between insulin resistance and total plasma homocysteine levels in type 2 diabetes mellitus patients in south west Nigeria

Ala, Oluwabukola; Akintunde, Adeseye A; Ikem, Rosemary; Kolawole, Babatope; Olufemi, Ogundipe; Adedeji, Tewogbade Adeoye

doi:10.1016/j.dsx.2017.06.002

Cited by 29 publications

(20 citation statements)

References 23 publications

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“…In this study, human HOMA-IR was positively associated with plasma Hcy levels, consistent with previous studies [ 24 , 25 , 26 ]. A positive association between plasma IL1β and Hcy levels was further observed in humans.…”

Section: Discussionsupporting

confidence: 93%

“…Apart from the cardiovascular effect of Hcy, a series of clinical studies have also revealed a closely association between HHcy and insulin resistance. Patients with insulin resistance and type II diabetes mellitus display increased plasma levels of Hcy [ 24 , 25 , 26 ]. A methylenetetrahydrofolate reductase C677T polymorphism that interferes with the methionine cycle and elevates plasma Hcy levels, is positively associated with insulin resistance [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

et al. 2018

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The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be a DAMP that activates adipocyte NLRP3 inflammasomes, participating in insulin resistance. Hcy-induced activation of NLRP3 inflammasomes were observed in both adipocytes and adipose tissue macrophages (ATMs) and mediated insulin resistance. Lysophosphatidylcholine (lyso-PC) acted as a second signal activator, mediating Hcy-induced adipocyte NLRP3 inflammasome activation. Hcy elevated adipocyte lyso-PC generation in a hypoxia-inducible factor 1 (HIF1)-phospholipase A2 group 16 (PLA2G16) axis-dependent manner. Lyso-PC derived from the Hcy-induced adipocyte also activated ATM NLRP3 inflammasomes in a paracrine manner. This study demonstrated that Hcy activates adipose NLRP3 inflammasomes in an adipocyte lyso-PC-dependent manner and highlights the importance of the adipocyte NLRP3 inflammasome in insulin resistance.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

et al. 2018

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“…Though the pathogenesis of GDM is still unknown, it is well-established that IR plays an important role in the onset of GDM. Many studies have showed that plasma tHcy levels are positively correlated with the degree of IR 6 , 7 . Hence, in recent years, some studies have explored the role of plasma tHcy in GDM.…”

Section: Discussionmentioning

confidence: 99%

The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population

Deng

Zhou

Tang

et al. 2020

Sci Rep

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To assess the correlation between plasma total homocysteine (tHcy) level and gestational diabetes mellitus (GDM) in a Chinese Han population. This case–control study included 350 GDM patients and 346 gestational week-matched normal glucose tolerance (NGT) pregnant women. Plasma tHcy and insulin levels were analyzed by HPLC and ELISA respectively. Logistic regression analysis was used to investigate the correlation between plasma tHcy level and risk of GDM. Women with GDM had a higher plasma tHcy level than NGT women (6.61 ± 1.32 vs. 6.17 ± 1.29 μmol/L, P = 0.001)). The GDM risk was 1.79 (OR = 1.79, 95% CI 1.18–2.72, P = 0.006) times higher in women whose plasma tHcy level was ≥ 7.29 μmol/L compared to women with plasma tHcy level < 5.75 μmol/L. Stratified analysis showed the GDM risk were much higher when HOMA-IR index ≥ 2 (OR = 5.42, 95% CI 2.51–11.74, P < 0.001), age ≥ 30 years (OR = 5.14, 95% CI 2.78–9.52, P < 0.001), or women with a family history of type 2 diabetes mellitus (T2DM) (OR = 4.13, 95% CI 1.78–9.56, P = 0.001). In the Chinese Han population, an elevated plasma tHcy level may increase the overall risk of GDM especially in women with a high HOMA-IR index, increasing age or with family history of T2DM.

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“…With regard to diabetes, the blood Hcy concentration was thought to increase under conditions of insulin resistance ( 61 , 62 ), which induces vitamin B consumption due to accelerated gluconeogenesis in the liver. Li et al previously showed that plasma Hcy levels in patients with T2DM were significantly increased compared with those in subjects without diabetes, and that higher plasma Hcy levels were independently associated with osteoporotic fractures in patients with T2DM ( 63 ).…”

Section: Dysfunction Of Osteoblasts and Osteocytes In Dmmentioning

confidence: 99%

Diabetes Mellitus-induced Bone Fragility

Kanazawa

Sugimoto

2018

Intern. Med.

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Accumulating evidence has shown that the risk of osteoporotic fractures is increased in patients with diabetes mellitus (DM). Thus, DM-induced bone fragility has been recently recognized as a diabetic complication. Because the fracture risk is independent of the reduction in bone mineral density, deterioration of the bone quality may be the main cause of bone fragility. Although its mechanism remains poorly understood, accumulated collagen cross-links of advanced glycation end-products (AGEs) and dysfunctions of osteoblast and osteocyte may be involved. Previous studies have suggested that various diabetes-related factors, such as chronic hyperglycemia, insulin, insulin-like growth factor-I, AGEs, and homocysteine, are associated with the risk of bone fragility caused by impaired bone formation and bone remodeling. Furthermore, several anti-diabetic drugs are known to affect bone metabolism and fracture risk. We herein review the association between DM and fracture risk as well as the mechanism of DM-induced bone fragility based on recent evidence.

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Association between insulin resistance and total plasma homocysteine levels in type 2 diabetes mellitus patients in south west Nigeria

Cited by 29 publications

References 23 publications

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population

Diabetes Mellitus-induced Bone Fragility

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