ASSOCIATION BETWEEN INSULIN,GHRELIN, HOMA-IR, HOMA-β, WHR AND BMI TO PLASMA GLUCOSE AND HbA1C AND ITS CLINICAL USEFULNESS IN T2DM PATIENTS WITH OBESITY

Abstract

Objectives: To evaluate new diabetic control monitoring parameters insulin, ghrelin, body mass index, waist-to-hip ratio, homeostasis model assessment-insulin resistance (HOMA-IR), and HOMA-β for Type 2 diabetes mellitus (T2DM) with obesity and to compare them with the existing diabetic control markers plasma glucose and glycosylated hemoglobin (HbA1c) and to recommended these additional tests to assess complications associated with kidney, liver, cardiac, and pancreas. Methods:A total of 100 T2DM patients with obesity who attended the sugar clinic attached to Apollo Speciality Hospitals, Vanagaram and who were on standard treatment and 50 age and sex matched controls attending the routine master health check in the same hospital were enrolled for the study. Fully automated analyzers and reagents and controls were used for all assays to ensure validity of the results obtained. For insulin and ghrelin assays, established commercial kits were used and all other parameters were calculated using formulae established previously. Graphpad online calculator was used to calculate t and p values. Results:The results obtained for both controls and patients for the set of additional parameters were compared with fasting plasma glucose (FPG), post prandial plasma glucose (PPPG), and HbA1c between controls, patients and controls with patients by calculating r and p values. Highly significant correlations were obtained in all comparisons. Conclusions:Very good associations (p<0.0001) were found between FPG, PPPG, and HbA1c to each of the new parameters for controls, patients and between controls and patients. These additional parameters may be done at fixed intervals of time to evaluate kidney, liver, cardiac and pancreatic complications/dysfunction in T2DM patients with obesity.