Association Between Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Coronary Artery Disease in Bosnian Population

Abstract

One of the genes considered as a risk factor for coronary artery disease (CAD) is the angiotensin-converting enzyme (ACE) gene. Many studies have been published regarding the relation between the ACE gene insertion/deletion (I/D) polymorphism and CAD. However, studies have provided controversial results. To explore this further in the population of Bosnia and Herzegovina, we compared the ACE I/D genotypes and alleles distribution between two groups: 100 CAD patients and 100 healthy control subjects. The higher distribution of DD genotype (47.0%) and D allele (65.5%) were found in CAD patients compared to controls (DD 34.0%; D allele 51.0%). Genotype odds ratio, (DD + ID) on the II, was 2.471 (1.252 – 4.876; 95% CI; p < 0.05). This leads to the conclusion that the DD genotype of the ACE I/D polymorphism affects the risk for development of coronary artery disease in Bosnian population.

Role of Insertion/Deletion Polymorphism for Angiotensin Converting Enzyme Gene in Hypertension

“…It has been determined that distribution of genotypes DD + ID, in regards to genotype I/I in compared groups of subjects has a significant statistical difference, p<0.05, what is in accordance to the results of certain researches in Europe and in the world. In population of Bosnia and Herzegovina it has been proven that D/D genotype, is related to an increasement of risk of developing a coronary artery disease (CAD) [17], [18]. Barbalic et al [19] in the study that included 119 subjects with hypertension and 125 healthy subjects had proven a link between I/D ACE polymorphism and DD genotype with risk of hypertension development in Croatian population.…”