Association between Influenza Vaccination and Positive SARS-CoV-2 IgG and IgM Tests in the General Population of Katowice Region, Poland

Kowalska, Małgorzata; Niewiadomska, Ewa; Barański, Kamil; Kaleta-Pilarska, Angelina; Brożek, Grzegorz; Zejda, Jan

doi:10.3390/vaccines9050415

Cited by 13 publications

(9 citation statements)

References 32 publications

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“…Of the 92 full-text articles identified, 58 were excluded because they did not meet the inclusion criteria, and two others were obtained from the references. The remaining 36 articles reported on 55,996,841 subjects outcomes were included in this analysis [21–56] . None of the participants had received COVID-19 vaccination during the study period.…”

Section: Resultsmentioning

confidence: 99%

Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis

Jiang

Huang

Jia

et al. 2022

Chinese Medical Journal

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Background: World Health Organization recommends that influenza vaccines should benefit as much of the population as possible, especially where resources are limited. Corona virus disease 2019 (COVID-19) has become one of the greatest threats to health systems worldwide. The present study aimed to extend the evidence of the association between influenza vaccination and COVID-19 to promote the former. Methods: In this systematic review, four electronic databases, including the Cochrane Library, PubMed, Embase, and Web of Science, were searched for related studies published up to May 2022. All odds ratios (ORs) with 95% confidence intervals (CIs) were pooled by meta-analysis. Results: A total of 36 studies, encompassing 55,996,841 subjects, were included in this study. The meta-analysis for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection provided an OR of 0.80 (95% CI: 0.73-0.87). The statistically significant estimates for clinical outcomes were 0.83 (95% CI: 0.72-0.96) for intensive care unit admission, 0.69 (95% CI: 0.57-0.84) for ventilator support, and 0.69 (95% CI: 0.52-0.93) for fatal infection, while no effect seen in hospitalization with an OR of 0.87 (95% CI: 0.68-1.10). Conclusion: Influenza vaccination helps limit SARS-CoV-2 infection and severe outcomes, but further studies are needed. Registration: PROSPERO, CRD42022333747.

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Section: Resultsmentioning

confidence: 99%

Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis

Jiang

Huang

Jia

et al. 2022

Chinese Medical Journal

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“…In the study carried out in Poznań (Poland) after the first wave of COVID-19 (July-September 2020), based on the ELISA results, it was found that 1.67% (95%CI 1.13–2.45) had antibodies against SARS-CoV-2 [ 25 ]. However, there were regions in Poland highly affected by COVID-19 and in a cross-sectional study located in three large towns of Silesian Voivodeship (Poland), the authors studied 5479 subjects in which 1253 (22.9%) had a positive anti-SARS-CoV-2 IgG test [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Seroprevalence in Healthcare Workers before the Vaccination in Poland: Evolution from the First to the Second Pandemic Outbreak

Korona-Głowniak

Mielnik

Podgajna

et al. 2022

IJERPH

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Healthcare workers (HCWs) are on the frontline, struggling with the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To describe recent or past infections, the serological assays enabled the assessment of the immune response developed in coronavirus disease (COVID-19) in the period when testing was hardly available. In this study, we investigated SARS-CoV-2 seroprevalence in HCWs in a Polish teaching hospital and the Regional Occupational Medicine Center after both the first and the second waves. ELISA-based tests for anti-SARS-CoV-2 IgA and IgG were used to determine immune response to SARS-CoV-2 in volunteer HCWs who worked in those institutions in May 2020 (208 participants aged 47.1 ± 12.5, 88% women) and in December 2020 (179 participants aged 45.2 ± 12.4, 86% woman). Risk factors for seropositivity were also assessed using a questionnaire filled out by all participants. We reported a significant increase in seroprevalence after the second wave (22.9%) compared with the first outbreak (2.4%) (OR 12.1; 95%CI 4.6–31.3; p < 0.0001). An association between IgG seroprevalence and severity of infections was noted. Furthermore, we demonstrated that amongst medical personnel, nurses exhibited a proportionally higher SARS-CoV-2 seroprevalence. Moreover, given the high seroprevalence in non-clinical group of HCWs, we suggest that community transmission can play a superior role to workplace exposure.

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“…The results from our analysis confirmed that the course of the COVID-19 epidemic in both compared years in the Silesian voivodeship was similar to that of seasonal influenza with a maximum of infections in colder months of the year [ 16 ]. The previous publications from our team suggest that vaccination against seasonal influenza was negatively associated with SARS-CoV-2 infection in the studied region [ 17 ]. Numerical simulation of available data from ten countries of the world highlighted the necessity of considering seasonal factors when formulating future intervention strategies [ 18 ].…”

Section: Discussionmentioning

confidence: 98%

Spatial Variability of COVID-19 Hospitalization in the Silesian Region, Poland

Kowalska

Niewiadomska

2022

IJERPH

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Assessment of regional variation in the COVID-19 epidemic is an important task for the implementation of effective action in public health, especially in densely populated regions. In this descriptive study, the temporal and spatial variability of morbidity and in-hospital mortality of COVID-19 in the Silesian Voivodship (Poland) was analyzed. Secondary epidemiological data of hospitalized patients due to COVID-19 from 1 March to 31 December 2020 and from 1 January to 31 December 2021 were obtained from the regional registry of the Silesian Voivodship Office in Katowice. A year by year (2020 versus 2021) comparative analysis showed a similar course pattern of the COVID-19 pandemic in the Silesian Voivodeship; with the worst situation occurring in the colder months of the year. The percentage of in-hospital mortality remained at a high level, close to 20% during the second year of observation. The risk of death in patients hospitalized due to COVID-19 increased with the number of comorbidities. The highest number of patients was documented in densely inhabited regions with intensive population movement (Częstochowa and border counties). The epidemiological ‘map’ facilitates the generation of hypotheses needed for the explanation of the observed epidemic hazard in one of the most populated regions of Poland.

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Association between Influenza Vaccination and Positive SARS-CoV-2 IgG and IgM Tests in the General Population of Katowice Region, Poland

Cited by 13 publications

References 32 publications

Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis

Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis

SARS-CoV-2 Seroprevalence in Healthcare Workers before the Vaccination in Poland: Evolution from the First to the Second Pandemic Outbreak

Spatial Variability of COVID-19 Hospitalization in the Silesian Region, Poland

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