Association between inflammatory markers in induced sputum and clinical characteristics in children with non‐cystic fibrosis bronchiectasis

Güran, Tülay; Ersu, Refika; Karadağ, Bülent; Akpınar, İhsan; Demirel, Gülderen Yanikkaya; Hekim, Nezih; Dağlı, Elif

doi:10.1002/ppul.20587

Cited by 34 publications

(28 citation statements)

References 39 publications

(57 reference statements)

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“…In previous studies, cases without an identified cause accounted for between 26 and 63% of all cases of non-CF pediatric bronchiectasis [17, 18] versus 55% in our study. All patients in whom the etiology could not be identified had a history of pneumonia.…”

Section: Discussionmentioning

confidence: 58%

“…In conclusion, our observations, together with those reported from other European countries [3, 8, 12, 17, 18, 42], provide additional insights into the characteristics of pediatric non-CF bronchiectasis in westernized societies. This study highlights the need for longitudinal evaluations, also using HRCT, of severe and nonresolving pneumonia in children.…”

Section: Discussionmentioning

confidence: 65%

“…Thanks to high-resolution computed tomography (HRCT), bronchiectasis is now identified more often in cystic fibrosis (CF) and in non-CF disease [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18]. Patients with bronchiectasis are generally treated in specialized centers.…”

Section: Introductionmentioning

confidence: 99%

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A Descriptive Study of Non-Cystic Fibrosis Bronchiectasis in a Pediatric Population from Central and Southern Italy

et al. 2008

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Background: Non-cystic fibrosis (CF) bronchiectasis is now identified more often than in the past. Objectives: It was the aim of this study to assess the high-resolution computed tomography (HRCT) localization and extent of bronchiectasis and to determine whether asthma status, atopy and bronchiectasis distribution are associated with the etiology of bronchiectasis. Methods: We retrospectively analyzed clinical, laboratory, functional and HRCT data of 105 children with non-CF bronchiectasis at 2 tertiary respiratory units in Italy. Forty cases had bronchiectasis associated with ongoing underlying conditions, namely primary ciliary dyskinesia, primary immunodeficiency or aspiration. Results: Age at the onset of chronic cough/wheeze and at the first X-ray-documented pneumonia as well as atopy prevalence were lower in patients with ongoing underlying conditions than in those without (p = 0.049, p = 0.003 and p = 0.0008, respectively). In most cases, bronchiectasis was multilobar, and a mean of 2.5 lobes were involved. The right side was more often involved than the left (88 vs. 70%; p = 0.002), and the upper lobes were relatively spared (p < 0.000001). Right lung involvement and multilobar disease were more prevalent in children younger than 2 years at first pneumonia (p < 0.05). Conclusions: Clinical information combined with laboratory data provides additional insights into the characteristics of non-CF bronchiectasis in a large population of Italian children. This study highlights the need for longitudinal evaluations, also using HRCT, of severe and non-resolving pneumonia in children.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 65%

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A Descriptive Study of Non-Cystic Fibrosis Bronchiectasis in a Pediatric Population from Central and Southern Italy

et al. 2008

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“…Bronchiectasis is a state of chronic inflammation. Although we did not measure inflammatory markers in our study population, we have recently shown that sputum IL-8 and TNF-α levels correlate positively with symptoms and severity scores of high-resolution CT, and negatively with lung function tests in children with non-CF bronchiectasis [28]. Increased inflammatory markers may also negatively affect BMD in patients with bronchiectasis [29].…”

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density in Children with Non-Cystic Fibrosis Bronchiectasis

Güran

Turan²,

Karadağ³

et al. 2007

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Background: Bronchiectasis presents as a common sequela of several chronic pulmonary diseases. Bone mineral density (BMD) is generally decreased in children with cystic fibrosis (CF). Although children with non-CF bronchiectasis have similar risk factors for osteopenia/osteoporosis, data on BMD in this group of patients are lacking. Objective: To evaluate BMD in children with non-CF bronchiectasis. Methods: In this study, we evaluated BMD of the radius and tibia in 32 children (17 girls) with non-CF bronchiectasis and in 23 healthy controls matched for age, sex and pubertal stage by quantitative ultrasound (speed of sound). Daily calcium intake and pulmonary function tests and data about steroid use were noted. Results: Mean age was 12.5 ± 4.6 years. Six children (18%) had moderate-to-severe lung disease (FEV₁ <60% predicted). All except 2 children (94%) were receiving inhaled steroids. There was no significant difference in BMD (expressed as z-score) of the radius and tibia between the patient and control groups (tibia z-scores: –0.1 ± 0.9 vs. –0.8 ± 0.8 and radius z-scores –1.3 ± 1.4 vs. –1.0 ± 0.9 in bronchiectasis patients and controls, respectively, p > 0.05). However, more children with non-CF bronchiectasis had osteopenia (z-scores between –1 and –2 SD) and osteoporosis (z-score ≤2 SD) compared to the control group (62 vs. 30%, p = 0.019). There was a significant correlation between age and radius z-scores (r = –0.365, p = 0.04). There was no correlation between BMD and severity of lung illness, calcium intake or cumulative steroid doses. Conclusion: Osteopenia is more common in children with non-CF bronchiectasis compared to controls and the risk of osteoporosis and osteopenia increases with age.

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“…Neutrophils are known to play a major role in the pathology of chronic obstructive respiratory diseases (COPD, chronic bronchitis and bronchiectasis) and are able to release chemokines such as IL-8 and RANTES as part of the inflammatory response [3,34,43,44,45,46,47,48,49]. MPO, the most abundant protein in neutrophils, plays a key role in neutrophil activation, catalyses the conversion of hydrogen peroxide (H 2 O 2 ) and chloride ions into hypochlorous acid (HOCl), and is an important enzyme in the host defence against bacteria, viruses and fungi [50].…”

Section: Discussionmentioning

confidence: 99%

Effect of Ambroxol and Beclomethasone on Lipopolysaccharide-Induced Nitrosative Stress in Bronchial Epithelial Cells

Ricciardolo¹,

Sorbello²,

Benedetto³

et al. 2015

Respiration

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Background: Nitrosative stress is involved in different airway diseases. Lipopolysaccharide (LPS) induces neutrophil-related cytokine release and nitrosative stress in human bronchial epithelial (BEAS-2B) cells alone or with human polymorphonuclear neutrophils (PMNs). Ambroxol protects against oxidative stress, and beclomethasone dipropionate is an anti-inflammatory drug. Objectives: We evaluated the ability of ambroxol and/or beclomethasone dipropionate to inhibit LPS-induced expression/release of RANTES, IL-8, inducible NO synthase (iNOS), myeloperoxidase (MPO) and 3-nitrotyrosine (3-NT: nitrosative stress biomarker) in BEAS-2B ± PMNs stimulated with LPS (1 μg/ml). Methods: The effect of ambroxol and/or beclomethasone dipropionate on IL-8, RANTES and iNOS levels was assessed by Western blot analysis; IL-8, MPO and 3-NT levels were measured by ELISA. Cell viability was assessed by the trypan blue exclusion test. Results: In BEAS-2B alone, LPS (at 12 h) increased RANTES/iNOS expression and IL-8 levels (p < 0.001). Ambroxol suppressed LPS-induced RANTES expression and IL-8 release (p < 0.001), whilst inhibiting iNOS expression (p < 0.05). Beclomethasone dipropionate had no effect on RANTES but halved iNOS expression and IL-8 release. Coculture of BEAS-2B with PMNs stimulated IL-8, MPO and 3-NT production (p < 0.001), potentiated by LPS (p < 0.001). Ambroxol and beclomethasone dipropionate inhibited LPS-stimulated IL-8, MPO and 3-NT release (p < 0.05). Ambroxol/beclomethasone dipropionate combination potentiated the inhibition of IL-8 and 3-NT production in BEAS-2B with PMNs (p < 0.05 and p < 0.01, respectively). Ambroxol and/or beclomethasone dipropionate inhibited nitrosative stress and the release of neutrophilic inflammatory products in vitro. Conclusion: The additive effect of ambroxol and beclomethasone dipropionate on IL-8 and 3-NT inhibition suggests new therapeutic options in the treatment of neutrophil-related respiratory diseases such as chronic obstructive pulmonary disease and respiratory infections.

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Association between inflammatory markers in induced sputum and clinical characteristics in children with non‐cystic fibrosis bronchiectasis

Cited by 34 publications

References 39 publications

A Descriptive Study of Non-Cystic Fibrosis Bronchiectasis in a Pediatric Population from Central and Southern Italy

A Descriptive Study of Non-Cystic Fibrosis Bronchiectasis in a Pediatric Population from Central and Southern Italy

Bone Mineral Density in Children with Non-Cystic Fibrosis Bronchiectasis

Effect of Ambroxol and Beclomethasone on Lipopolysaccharide-Induced Nitrosative Stress in Bronchial Epithelial Cells

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