Association between inflammatory markers and frailty in institutionalized older men

Lai, Hung-Wen; Chang, Hsiao-Ting; Lee, Yungling Leo; Hwang, Shinn‐Jang

doi:10.1016/j.maturitas.2014.07.014

Cited by 44 publications

(24 citation statements)

References 22 publications

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“…The Cardiovascular Health Study (CHS) by Walston et al showed a significant relation of elevated CRP levels with frailty after excluding cardiovascular disease and diabetes and adjusting for basic demographic characteristics, and the published data from the Longitudinal Aging Study Amsterdam (LASA) [28, 42]. Although a large number of studies show an association between serum CRP levels and the presence of frailty in older patients, few others do not support these findings, concluding that no significant associations are found [12, 16]. …”

Section: Frailty and Crpmentioning

confidence: 99%

C-Reactive Protein and Frailty in the Elderly: A Literature Review

et al. 2017

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Chronic inflammation is a well-established background process in many age-related diseases. Many recent studies investigate the use of various inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6, and interleukin-1 as predictors of physical and cognitive performance among elders. The phenotype of frailty has also been associated with underlying inflammatory mechanisms. The aim of this article was to review the literature referring to the correlation of CRP serum levels and frailty in older individuals. We tried to identify all relevant publications regarding the relation of CRP as an index of frailty in the elderly and its potential use. Although many studies in the recent medical literature positively associate serum CRP levels and frailty in older individuals, some do not, and some raise some interesting questions and set the basis for future studies. The association of CRP and frailty in elder patients should be considered when clinicians interpret inflammatory biomarkers in various clinical settings in such patients. Well-designed, prospective clinical trials are warranted to better assess the role and pathophysiology of frailty in the elderly and its mechanisms as also the exact role of CRP as an inflammatory marker and as a prognostic index in this syndrome.

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Section: Frailty and Crpmentioning

confidence: 99%

C-Reactive Protein and Frailty in the Elderly: A Literature Review

et al. 2017

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“…IL-6 was reported to be associated with frailty independent of underlying comorbidities in older men. 5 In a populationbased longitudinal study of 2,146 older people, CRP and fibrinogen were significant predictors of incident frailty in women. 6 In another study, CRP, IL-6, and TNF-a were found to be associated with frailty in individuals aged 85 and older, 7 although contrary to these findings, no association was seen in some studies.…”

Section: Comments/responses Associations Between Inflammation and Cogmentioning

confidence: 99%

Absence of Pleocytosis in Cerebrospinal Fluid does not Exclude Herpes Simplex Virus Encephalitis in Elderly Adults

Hébant

Miret²,

Bouwyn

et al. 2015

J American Geriatrics Society

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To the Editor: Herpes simplex virus encephalitis (HSVE) is the most-common cause of viral encephalitis in developing countries. HSVE is a medical emergency, and diagnosis is essential to reduce mortality and morbidity. Diagnosis is definitely established by the detection of viral deoxyribonucleic acid using polymerase chain reaction (PCR) in the cerebrospinal fluid (CSF). Initial CSF examination is nearly always abnormal and discloses pleocytosis. Two individuals who presented with HSVE confirmed using PCR despite lack of CSF pleocytosis are reported here. CASE REPORT Patient 1A 90-year-old man was referred for a fall with right shoulder trauma. His medical history included hypertension, dyslipidemia, and moderate chronic renal failure due to nephroangiosclerosis. At admission, he had a fever (39.9°C) and was confused. He had no neurological focal signs. Brain computed tomography (CT) was unremarkable. Blood tests revealed inflammation, with a high C-reactive protein level (39.9 mg/L; normal <5 mg/L) and normal white blood cell count (7,800/lL, normal <10,000/ lL). Cytobacteriological examination of the urine (CBEU) and blood culture were negative. CSF examination disclosed 1 leukocyte/lL (normal <5 leukocytes/lL) and 400 red blood cells/lL (normal <5/lL), protein level 1.23 g/L (normal <0.40 g/L), and glucose level 3.67 mmol/L (normal 3.0-4.5 mmol/L). Aerobic and anaerobic CSF cultures were negative, but HSV1 in the CSF was positive according to PCR. Intravenous acyclovir was introduced (10 mg/kg three times a day) for 15 days. Noticeable improvement allowed him to be discharged home. Patient 2An 80-year-old man was referred for dyspnea. His medical history included a myeloproliferative disorder diagnosed 5 years earlier with splenic, diaphragmatic, and pulmonary involvement. At diagnosis, no histopathological examination had been performed. Chloraminophene had been initiated 2 years before. He also had severe chronic obstructive pulmonary disease requiring oxygen therapy, cardiac arrhythmia, and a prostate adenocarcinoma treated by surgery and radiotherapy. At admission, clinical examination showed mild dyspnea, axillary nodes (related to the myeloproliferative disorder), and hepatosplenomegaly. He had no fever. The day after admission, he had a generalized tonic clonic seizure occurring with fever of 39°C without neurological focal signs. Brain CT was normal; electroencephalography revealed frontotemporal slow waves. Blood tests showed no inflammation. CBEU and blood culture were negative. CSF examination revealed 1 leukocyte/lL and 1 red blood cell/ lL, protein of 0.78 g/L, and glucose of 4.8 mmol/L.Because he was considered to be immunocompromised, and despite CSF examination results, intravenous acyclovir (10 mg/kg every 8 hours) was introduced. Ceftriaxone was also initiated because of a suspected associated pneumopathy. HSV1 PCR detection in CSF was positive. After temporary improvement, his neurological status worsened, with partial status epilepticus. He died 5 days after admission.Two individuals who p...

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“…The relationship between inflammatory mediators and oxidative stress with frailty, mainly Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), homocysteine and oxidative stress has been examined (Lai et al 2014). Significant relationships were reported with higher level of IL-6 (Almeida et al 2012;Collerton et al 2012;Lai et al 2014), whilst the relationships with higher level of CRP and TNF-α were controversial.…”

Section: Introductionmentioning

confidence: 99%

Blood Inflammatory Markers, Anabolic Hormone, Vitamin D and L-Carnitine Status According to Frailty Status among Older Adults

Badrasawi¹,

Shahar²,

Rajab³

et al. 2019

JSM

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Frailty is associated with functional decline and reduced ability to cope with physiological challenges. The pathophysiological changes in frailty include inflammation, endocrine disturbances, neuromuscular and immune dysfunction. However, comprehensive information on the relationship between biological markers and frailty is scarce. We aimed to determine the relationship between selected biomarkers and frailty among Malaysian older adults. In this cross sectional study, 600 community dwelling older adults were randomly selected from ten different areas in Klang Valley. A total of 382 participants met the inclusion criteria and consented to the study. Out of these, a subsamples of 91 participants were selected for biomarkers analysis. Frailty was defined using Fried's criteria. Fasting blood glucose, lipid profile, albumin, selected frailty biomarkers including IL-6, TNF-alpha and IGF-1 and vitamin D together with free L-carnitine and acetyl L-carnitine were analysed. The results showed a significantly higher level of serum IL-6 and TNF-α among participants classified as frail as compared to pre-frail and robust (p<0.05). With respect to nutritional biomarkers, binary logistic regression showed that vitamin D deficiency is associated with three times higher risk of frailty (p<0.05). There was no significant relationship between blood L-carnitines and frailty. Further research is required to explore the relationship between L-carnitine and frailty using different parameters involved in L-carnitine homeostasis such as CPTII enzyme and OCTN2 mutation. In conclusion, frailty was associated with increased level of inflammatory markers and vitamin D deficiency. It is empirical to promote healthy lifestyle or disease management to reduce inflammation and increase vitamin D status as one of the frailty prevention action plan among older adults.ABSTRAK Keuzuran adalah berkaitan dengan kemerosotan status kefungisan dan keupayaan dalam menangani cabaran fisiologi. Perubahan patofisiologi keuzuran termasuklah ketakfungsian ototneuro, ketakupayaan fungsi imun, inflamasi dan gangguan endokrin. Namun begitu, tidak banyak penyelidikan yang mengkaji hubungan antara petunjuk biologi dan keuzuran secara menyeluruh. Oleh itu, kajian ini menentukan hubungan antara petunjuk biologi tertentu dan status keuzuran dalam kalangan warga emas. Seramai 600 orang warga emas daripada komuniti dipilih secara rawak dari 10 buah kawasan di Lembah Klang. Seramai 382 peserta memenuhi kriteria kajian dan bersetuju mengambil bahagian. Seramai 91 subjek dipilih daripada sampel keseluruhan untuk analisis petunjuk biologi. Keuzuran didefinasikan daripada kriteria Fried. Petunjuk biokimia keuzuran yang dikaji termasuk IL-6, TNF-alfa dan IGF-1 serta vitamin D, bersamasama dengan L-karnitin bebas dan asetil L-karnitin dianalisis. Keputusan menunjukkan aras plasma darah IL-6 dan TNF-α adalah lebih tinggi secara signifikan dalam kumpulan uzur berbanding, prauzur dan robus (p<0.05). Berhubung dengan petunjuk biologi pemakanan, analisis logistik binari menunjuk...

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Association between inflammatory markers and frailty in institutionalized older men

Cited by 44 publications

References 22 publications

C-Reactive Protein and Frailty in the Elderly: A Literature Review

C-Reactive Protein and Frailty in the Elderly: A Literature Review

Absence of Pleocytosis in Cerebrospinal Fluid does not Exclude Herpes Simplex Virus Encephalitis in Elderly Adults

Blood Inflammatory Markers, Anabolic Hormone, Vitamin D and L-Carnitine Status According to Frailty Status among Older Adults

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