Association between Inflammatory Marker, Environmental Lead Exposure, and Glutathione S-Transferase Gene

Abstract

A number of studies suggested that lead is related to the induction of oxidative stress, and alteration of immune response. In addition, modifying these toxic effects varied partly by GST polymorphism. The objectives of this study were to assess the association between the lead-induced alteration in serum hs-CRP, with GSTM1, GSTT1, and GSTP1 Val105Ile genetic variations and the health consequence from environmental lead exposure. The 924 blood samples were analyzed for blood lead, CRP, and genotyping of three genes with real-time PCR. Means of blood lead and serum hs-CRP were 5.45 μg/dL and 2.07 mg/L. Both CRP and systolic blood pressure levels were significantly higher for individuals with blood lead in quartile 4 (6.48–24.63 μg/dL) compared with those in quartile 1 (1.23–3.47 μg/dL, P < 0.01). In particular, in men with blood lead >6.47 μg/dL the adjusted odds ratio (OR) of CRP levels for individuals with GSTP1 variants allele, GSTM1 null, GSTT1 null, double-null GSTM1, and GSTT1 compared with wild-type allele was 1.46 (95% CI; 1.05–2.20), 1.32 (95% CI; 1.03–1.69), 1.65 (95% CI; 1.17–2.35), and 1.98 (95% CI; 1.47–2.55), respectively. Our findings suggested that lead exposure is associated with adverse changes in inflammatory marker and SBP. GST polymorphisms are among the genetic determinants related to lead-induced inflammatory response.

Effect of occupational exposure to lead on new risk factors for cardiovascular diseases

“…Unequivocal results were obtained within the Electric Generating Authority of Thailand (EGAT 2) programme 21. The examined population of men environmentally exposed to Pb (n=924) was divided into quartiles based on the average Pb concentration in the blood (24.4; 39.5; 57.7; 92.1 µg/L).…”

Effects of genetic polymorphisms on antioxidant status and concentrations of the metals in the blood of riverside Amazonian communities co-exposed to Hg and Pb

“…Participants with GSTT1 null polymorphism had higher Pb in blood when compared to those that expressed the enzyme. A recent study carried out by Sirivarasai et al (2013) showed that polymorphisms in GSTM1, GSTT1, as well as double deletion of GSTM1/GSTT1 altered inflammatory parameters in Thai subjects exposed to Pb (levels ranged from 6.5 to 25 mg/dL). Here, we did not observed effects of GSTM1/GSTT1 double deletion on either Hg or Pb concentrations.…”

Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: The Normative Aging Study

“…Glutathione-s-transferase Pi1(GSTP1) has been shown to reduce the effects of oxidative stress through free radical clearance (Hayes and Strange, 2000), and may modify the relationship between lead and cognitive function in the elderly (Eum et al, 2013) and inflammatory markers in adult males (Sirivarasai et al, 2013). Finally, the gene TfC2 encodes the transferrin protein that is responsible for iron transport, and interacts with HFE (Namekata et al, 1997).…”