Association between Inflammation and Biological Variation in Hemoglobin A1c in U.S. Nondiabetic Adults

Liu, Shuqian; Hempe, James M.; McCarter, Robert; Li, Shengxu; Fonseca, Vivian

doi:10.1210/jc.2014-4454

Cited by 79 publications

(74 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These observations sit coherently with interrelationships of glucose, glycation, AGE production, oxidative stress, and inflammation in the genesis of diabetes complications (23), enhanced by the evidenced link between adipose dysmetabolism, inflammation, and the shift in LAR as a key orchestrator of such dysmetabolism (24). Regarding inflammation, we only measured PAI-1, but others have shown a relationship of CRP with hemoglobin glycation index (HGI) (25) and, further, with carotid artery intimal thickness (26).…”

Section: Discussionsupporting

confidence: 71%

Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes

et al. 2017

View full text Add to dashboard Cite

The phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in deglycation in turn leading to altered production of advanced glycation end products (AGEs). We hypothesized that variations in the level of the deglycating enzyme fructosamine-3-kinase (FN3K) might be associated with the GGap. We measured erythrocyte FN3K concentrations and enzyme activity in a population dichotomized for a large positive or negative GGap. FN3K protein was higher and we found a striking threefold greater activity (323%) at any given FN3K protein level in the erythrocytes of the negative-GGap group compared with the positive-GGap group. This was associated with lower AGE levels in the negative-GGap group (79%), lower proinflammatory adipokines (leptin-to-adiponectin ratio) (73%), and much lower prothrombotic PAI-1 levels (19%). We conclude that FN3K may play a key role in the GGap and thus diabetes complications such that FN3K may be a potential predictor of the risk of diabetes complications. Pharmacological modifications of its activity may provide a novel approach to their prevention.

show abstract

Section: Discussionsupporting

confidence: 71%

Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In addition, chronic in ammation was recognized to be involved in the development of hypertension [37]. The National Health and Nutrition Examination Survey previously suggested that HGI was independently associated with in ammatory biomarkers including C-reactive protein (CRP), polymorphonuclear leukocytes, and monocytes [38]. Following 6 weeks of low-AGEs diet intervention in diabetics, the concentrations of in ammatory markers such as high-sensitivity C-reactive protein and TNFα were signi cantly reduced [39].…”

Section: Discussionmentioning

confidence: 99%

Association of hemoglobin glycation index and its interaction with obesity /family history of hypertension on hypertension risk: a community-based cross-sectional survey

Song

Zhao

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: Hemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods : The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.Results: Specifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.Conclusion: High HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

show abstract

“…Lipid panel readings provided fasting high-and low-density lipoprotein cholesterol and triglycerides. 28 Serum adiponectin concentrations 29 and percentage of HbA1c 30 (in National Glycohemoglobin Standardization Program units, using a high−performance liquid chromatography system) were collected after a minimum 8 hours of fasting. Left ventricle fraction to the nearest 5%, derived by a study cardiologist from a modified Quinones technique, served as a semiquantitative measurement of left ventricular systolic function.…”

Section: Methodsmentioning

confidence: 99%

Perceived Discrimination and Trajectories of C-Reactive Protein: The Jackson Heart Study

Sims

Glover

et al. 2020

American Journal of Preventive Medicine

View full text Add to dashboard Cite

Introduction: Perceiving discriminatory treatment may contribute to systemic inflammation, a risk factor of cardiovascular pathophysiology. This study evaluated the association of self-reported discrimination with changes in high−sensitivity C-reactive protein and the mediating role of adiposity. Methods: The sample included 5,145 African-Americans, aged 21−92 years, in the Jackson Heart Study. Everyday, lifetime, and burden from perceived discrimination comprised primary predictors in 3 sets of multivariable linear regression models of baseline (2000−2004) discrimination and natural logarithm of high−sensitivity C-reactive protein. Multivariable linear mixed models assessed mean changes in natural logarithm of high−sensitivity C-reactive protein over the study period (2000−2013). Mediation was quantified by percentage changes in estimates adjusted for BMI, waist circumference, and waist-to-height ratio. Multiple imputation addressed missingness in baseline covariates and in high−sensitivity C-reactive protein taken at all 3 study examinations. Analyses were conducted in 2018. Results: In cross-sectional analyses, male participants in the middle and highest tertiles of lifetime discrimination had natural logarithm of high−sensitivity C-reactive protein levels that were 0.13 (95% CI= À0.24, À0.01) and 0.15 (95% CI= À0.27, À0.02) natural logarithm(mg/dL) lower than those in the lowest tertile. In longitudinal analyses, all participants reporting more frequent everyday discrimination had a 0.07 natural logarithm(mg/dL) greater increase in natural logarithm of high−sensitivity C-reactive protein per examination than those reporting none (95% CI=0.01, 0.12). A similar trend emerged for lifetime discrimination and changes in natural logarithm of high −sensitivity C-reactive protein (adjusted mean increase per visit: 0.04 natural logarithm[mg/dL], 95% CI=0.01, 0.08). Adiposity did not mediate the longitudinal associations. Conclusions: Everyday and lifetime discrimination were associated with significant high−sensitivity C-reactive protein increases over 13 years. The physiologic response to discrimination may lead to systemic inflammation.

show abstract

Association between Inflammation and Biological Variation in Hemoglobin A1c in U.S. Nondiabetic Adults

Abstract: HGI reflects the effects of inflammation on HbA1c in a nondiabetic population of U.S. adults and may be a marker of risk associated with inflammation independent of FPG, race, and obesity.

Cited by 79 publications

References 41 publications

Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes

Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes

Association of hemoglobin glycation index and its interaction with obesity /family history of hypertension on hypertension risk: a community-based cross-sectional survey

Perceived Discrimination and Trajectories of C-Reactive Protein: The Jackson Heart Study

Contact Info

Product

Resources

About