Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case–control study in Thailand

Poosari, Arisara; Nutravong, Thitima; Sa-Ngiamwibool, Prakasit; Namwat, Wises; Chatrchaiwiwatana, Supaporn; Ungareewittaya, Piti

doi:10.1186/s40001-021-00561-3

Cited by 11 publications

(13 citation statements)

References 43 publications

(33 reference statements)

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“…The elevated abundance of Streptococcus in the gut microbiota is related to gastric cancer occurrence and liver metastasis (Yu et al, 2021). Although no evidence supports a direct relationship between Campylobacter and breast cancer, Campylobacter is related to esophageal cancer occurrence (Poosari et al, 2021). The commonly increased taxa Streptococcus, Campylobacter, and Moraxellaceae in BN and BM subjects could be risk factors for breast cancer occurrence.…”

Section: Discussionmentioning

confidence: 99%

Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis

Xie

Chen

et al. 2022

Front. Microbiol.

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Breast cancer is the most common cancer in women and the second most common cancer overall. Although advancements in the early diagnosis and therapy of breast cancer have occurred in recent years, the prognosis of breast cancer bone metastasis remains poor and this type of cancer is rarely cured. The gut microbiota is indispensable for internal homeostasis and regulates various biological processes. Understanding the gut microbiota profiles in normal controls (NCs), breast cancer patients with no metastasis (BNs), and breast cancer patients with bone metastasis (BMs) may shed light on the development of diagnostic and therapeutic targets for breast cancer and bone metastasis. We comprehensively analyzed the gut microbiota from NCs, BNs, and BMs and found that the community diversity decreased in the order of NCs, BNs, and BMs. Streptococcus, Campylobacter and Moraxellaceae showed higher abundances in BNs and BMs than in NCs. The lack of Megamonas and Akkermansia in the BM compared with those in the NC and BN groups was considered related to bone metastasis. Additionally, based on the distinct gut microbiota profiles, we predicted that lipid transportation and metabolism, as well as folate biosynthesis, participate in breast cancer occurrence and that steroid hormone biosynthesis influences bone metastasis. Our study demonstrated that variations in gut microbiota are associated with breast cancer occurrence and bone metastasis, providing attractive targets to develop therapeutic and diagnostic methods.

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Section: Discussionmentioning

confidence: 99%

Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis

Xie

Chen

et al. 2022

Front. Microbiol.

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“…A large body of published research has consistently demonstrated poor oral hygiene was associated with a higher risk of cancers, such as oral cancer (Deng et al, 2021), gastric cancer (Zhang et al, 2021), colorectal cancer (Wang et al, 2021). Based on the outcomes of two case-control studies, poor oral hygiene was an important risk factor for EC (Mmbaga et al, 2020;Poosari et al, 2021). And patients who received dental prophylaxis had a reduced risk of EC (Lee et al, 2014).…”

Section: Oral Hygienementioning

confidence: 99%

Human Microbiota in Esophageal Adenocarcinoma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Implications

et al. 2022

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Esophageal adenocarcinoma (EAC) is one of the main subtypes of esophageal cancer. The incidence rate of EAC increased progressively while the 5-year relative survival rates were poor in the past two decades. The mechanism of EAC has been studied extensively in relation to genetic factors, but less so with respect to human microbiota. Currently, researches about the relationship between EAC and the human microbiota is a newly emerging field of study. Herein, we present the current state of knowledge linking human microbiota to esophageal adenocarcinoma and its precursor lesion—gastroesophageal reflux disease and Barrett’s esophagus. There are specific human bacterial alternations in the process of esophageal carcinogenesis. And bacterial dysbiosis plays an important role in the process of esophageal carcinogenesis via inflammation, microbial metabolism and genotoxicity. Based on the human microbiota alternation in the EAC cascade, it provides potential microbiome-based clinical application. This review is focused on novel targets in prevention, diagnosis, prognosis, and therapy for esophageal adenocarcinoma.

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“…Other studies that suggested EC risk factors in Asian populations reported heterogeneous results from retrospective or casecontrol studies, and from cohort studies conducted decades ago, when environmental factors and lifestyles were very different. [27][28][29][30][31] There are obvious differences between risk factors and survival rates. The survival rate of SCC is lower than that of adenocarcinoma, so it is necessary to conduct a detailed comparative analysis of histological differences.…”

Section: Discussionmentioning

confidence: 99%

“…However, tobacco and alcohol consumption are not strong risk factors in that belt. Other studies that suggested EC risk factors in Asian populations reported heterogeneous results from retrospective or case–control studies, and from cohort studies conducted decades ago, when environmental factors and lifestyles were very different 27–31 . There are obvious differences between risk factors and survival rates.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological landscape of esophageal cancer in Asia: Results from GLOBOCAN 2020

et al. 2023

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Background Esophageal cancer (EC) is a global health problem. Asia represents a huge burden of EC globally, and incidence and mortality vary considerably across different Asian regions. Methods Data on incidence, mortality, and preference were extracted from GLOBOCAN 2020. Age‐standardized incidence and mortality rates were calculated overall by sex, age, country, region, and continent. The predicted burden of incidence and mortality in 2040 was calculated based on global demographic projections. Results It was estimated there were 481 552 new cases of and 434 363 deaths from EC in Asia in 2020, accounting for 79.7% and 79.8% of world EC cases and deaths, respectively. EC incidence and mortality in Asia ranked the highest among all continents. Eastern Asia represents the highest age‐standardized world incidence rate (ASWIR) of 12.3 per 100 000 for all Asian regions. Western Asia represents the lowest ASWIR of 1.7 per 100 000, accounting for 0.7% of the globe. There exist obvious differences in epidemiological features in Asian countries, including incidence, mortality, prevalence, and mortality incidence ratio. There is forecast to be up to 781 000 new cases of EC in Asia by 2040, with increasing rates of 63% for incidence and 72% for mortality from 2020. Conclusions Asia has an increasing number of EC cases and deaths. Strategies for targeting in high‐incidence areas, the elderly, and survival should be prioritized to reduce the global EC burden, especially in low‐ and middle‐income countries in Asia.

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Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case–control study in Thailand

Cited by 11 publications

References 43 publications

Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis

Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis

Human Microbiota in Esophageal Adenocarcinoma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Implications

Epidemiological landscape of esophageal cancer in Asia: Results from GLOBOCAN 2020

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