Association between industry affiliation and position on cardiovascular risk with rosiglitazone: cross sectional systematic review

Abstract

Objective To explore a possible link between authors' financial conflicts of interest and their position on the association of rosiglitazone with increased risk of myocardial infarction in patients with diabetes.

Reporting of Conflicts of Interest in Meta-Analyses of Trials of Pharmacological Treatments

“…[6][7][8] Compared with nonindustry-funded trials, pharmaceutical industry-funded studies more often yield results or conclusions in support of the sponsor's drug, [9][10][11][12][13][14][15][16] and authors' relationships with drug manufacturers have been linked to favorable assessments of drug efficacy and safety. [17][18][19][20] As a result, increased emphasis has been placed on the transparent disclosure of COI. The Consolidated Standards of Reporting Trials (CONSORT) guidelines require disclosure of study funding sources in trial reports.…”

Editor's Choice

“…A good practical example is that, in the wake of reports regarding the risk of myocardial infarction in diabetics treated with rosiglitazone, authors who had favourable views on the safety of rosiglitazone were three times more likely to have a financial conflict of interest with a pharmaceutical company than were authors who had unfavourable views. [8] The Ebola epidemic rages on … As the Ebola epidemic rages, [9,10] clinicians should ask every febrile patient: 'Which African country(ies) have you recently visited?' We are also reminded that the occupational risk of infection by blood-borne viruses (BBVs) in healthcare practitioners (HCPs) and students is significant, especially in the developing world.…”

Who will guard the guards? Medical leadership and conflict of interest in South African healthcare

“…Nearly a quarter of these articles with authors with COI did not disclose this, with 3.3% actively declaring no COI when one did in fact exist. [25] Interventions for dealing with COI Disclosure Much of the information on the effect of disclosure is derived from social science experiments on university student volunteers.…”