Association between impulsivity, reward responsiveness and body mass index in children

Berg, Linda van den; Pieterse, Karlijn; Malik, Jamil A.; Luman, Marjolein; Dijk, Ko Willems van; Oosterlaan, Jaap; Waal, Henriëtte A. Delemarre-van de

doi:10.1038/ijo.2011.116

Cited by 102 publications

(67 citation statements)

References 39 publications

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“…A recent study examining inhibitory control in children suggested that high impulsivity was linked with obesity (31). Impulsivity and reward sensitivity have specifically been found to influence BMI through overeating (32) and high levels of impulsivity may be associated with a rebound effect after eating (7). Impulsivity has also been linked to weight loss failure, with more impulsive children losing less weight.…”

Section: Discussionmentioning

confidence: 99%

Association between binge eating and attention‐deficit/hyperactivity disorder in two pediatric community mental health clinics

Reinblatt

Leoutsakos

Mahone

et al. 2014

Intl J Eating Disorders

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Objective Attention-Deficit/ Hyperactivity Disorder (ADHD) has been linked with obesity; however its relationship with binge eating (BE) is less clear. We aimed to explore the associations among ADHD, weight and BE in pediatric mental health clinics. Method We retrospectively reviewed consecutive intakes in two pediatric mental health clinics (N=252). BE was assessed using the C-BEDS scale. Associations between ADHD, BE, and BMI-z score were assessed via regression. Results Mean age was 10.8 (3.7 SD) years. Twelve percent (n= 31) had BE. The association between ADHD and BE was statistically significant (OR 16.1, p < 0.001), and persisted after adjusting for comorbid diagnoses, medications, demographic variables and clinic. There was a statistically significant association between ADHD and BMI z-scores (β=0.54, p < 0.001). After adjusting for BE, the relationship between ADHD and BMI z-scores was attenuated (β=0.35, p=0.025), and the coefficient for BE was decreased (β=0.75, p=0.001). Although stimulant use was associated with a three-fold increase in odds of BE (OR 3.16, p=0.006), stimulants were not associated with greater BMI-z scores (β=0.18, p=0.32). Discussion There was a significant association between ADHD and BE in two pediatric mental health clinics. Although these data are cross-sectional, and cannot be used to make causal inferences, these findings are compatible with the hypothesis that BE partially mediates the association between ADHD and BMI z-scores. In mental health clinics, children with ADHD may present as overweight or obese. Further, children with ADHD may exhibit BE. Future prospective studies should elucidate the complex relationships among ADHD, weight, stimulants and BE.

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Section: Discussionmentioning

confidence: 99%

Association between binge eating and attention‐deficit/hyperactivity disorder in two pediatric community mental health clinics

Reinblatt

Leoutsakos

Mahone

et al. 2014

Intl J Eating Disorders

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“…Impaired response inhibition is a behavioral trait of which impaired satiety may be one manifestation. A related trait – impulsivity – has been linked to obesity [36-38] and poor obesity treatment outcomes in children [37]. …”

Section: Discussionmentioning

confidence: 99%

Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention

et al. 2013

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BackgroundDopamine receptors are involved in midbrain reward circuit activation. Polymorphisms in two dopamine receptor genes, DRD2 and DRD4, have been associated with altered perception of food reward and weight gain. The objective of this study was to determine whether the same risk alleles were associated with overweight/obesity and with lower reduction of overweight after a 1-year lifestyle intervention.MethodsIn a longitudinal study the association of polymorphisms in DRD2 (rs18000497, risk allele: T, formerly A1 allele at the TaqI A1 polymorphism) and DRD4 (variable number of tandem repeats (VNTR); 48 bp repeat in exon III; risk alleles: 7 repeats or longer: 7R+) was tested on weight loss success following a 1-year lifestyle childhood obesity intervention (OBELDICKS). An additional exploratory cross-sectional case-control study was performed to compare the same DRD polymorphisms in these overweight/obese children and adolescents versus lean adult controls. Subjects were 423 obese and 28 overweight children participating in lifestyle intervention (203 males), age median 12.0 (interquartile range 10.0–13.7) years, body mass index - standard deviation score (BMI-SDS) 2.4 ± 0.5; 583 lean adults (232 males); age median 25.3 (interquartile range 22.5–26.8) years, BMI 19.1 ± 1.9 kg/m2. BMI, BMI-SDS and skinfold thickness measures were assessed at baseline and after 1 year; genotyping was performed for DRD2 risk variant rs1800497 and DRD4 exon III VNTR.ResultsThe DRD2 genotype had a nominal effect on success in the weight loss intervention. The weakest BMI-SDS reduction was in children homozygous for two rs1800497 T-alleles (n = 11) compared to the combined group with zero (n = 308) or one (n = 132) rs1800497 T-allele (-0.08 ± 0.36 vs. -0.28 ± 0.34; p < 0.05). There was no association between the DRD4 VNTR alleles and genotypes and success in the weight loss intervention. No associations of the risk alleles of the DRD2 and DRD4 polymorphisms and obesity were observed in the cross-sectional part of the study.ConclusionsWe did not find association between polymorphisms in DRD2 and DRD4 genes and weight status. However, obese carriers of two DRD2 rs1800497 T-alleles may be at risk for weak responses to lifestyle interventions aimed at weight reduction.Trial registrationObesity intervention program “Obeldicks” is registered at clinicaltrials.gov (NCT00435734).

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“…(Anzman and Birch 2009;Van den Berg et al 2011). Impulsive children exhibit externally motivated, emotional eating, but, notably, not when parents monitor them (Farrow 2012).…”

Section: ___________________mentioning

confidence: 99%

All in the Family? Parental Roles in the Epidemic of Childhood Obesity

2016

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Childhood obesity is a serious global health challenge. Families and consumption are at the nexus of the problem, as childhood weight issues depend significantly on family-related influences (genetic predispositions, physical activities, and household food consumption practices). This article focuses on how a family socializes a child toward or away from obesity. It advances a family consumer socialization framework to characterize key elements and processes.Biological predispositions, parent/family inputs, elements of child development, parent-child interactions, and intergenerational transfer are all major contributors to weight status and life course potentials. Time is also a crucial component, here represented in two forms --linear and cyclical. Drawing on extensive research from other disciplines and related consumer research, five "Foundational Properties" are distilled, representing fundamental tenets underpinning the family's role in this problem. Each property is then used to chart promising opportunities for consumer researchers and others interested in advancing knowledge on this pressing concern.

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Association between impulsivity, reward responsiveness and body mass index in children

Cited by 102 publications

References 39 publications

Association between binge eating and attention‐deficit/hyperactivity disorder in two pediatric community mental health clinics

Association between binge eating and attention‐deficit/hyperactivity disorder in two pediatric community mental health clinics

Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention

All in the Family? Parental Roles in the Epidemic of Childhood Obesity

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