Association Between Immunosuppressive Therapy and Outcome of Clostridioides difficile Infection: Systematic Review and Meta-Analysis

Li, Yiting; Cai, Haifeng; Sussman, Daniel A.; Donet, Jean A.; Dholaria, Kevin; Yang, Jiajia; Panara, Ami; Croteau, Ryan; Barkin, Jamie S.

doi:10.1007/s10620-021-07229-2

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…The use of corticosteroids increases the risk of C. difficile colonization in adults admitted to the hospital [ 14 ] and immunosuppressive therapy is a risk factor for complicated CDI [ 15 ]. Immunocompromised patients have a higher risk of developing rCDI during hospitalization [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota Composition Associated with Clostridioides difficile Colonization and Infection

et al. 2022

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Clostridioides difficile is an anaerobic Gram-positive and spore-forming bacterium. The majority of C. difficile strains produce two toxins, A and B, associated with the development of acute diarrhea and/or colitis. In this review, two situations are distinguished: C. difficile infection (CDI) and asymptomatic colonization (AC). The main objective of this review is to explore the available data related to the link between the gut microbiota and the development of CDI. The secondary aim is to provide more information on why some people colonized with toxigenic C. difficile develop an infection while others show no signs of disease. Several factors, such as the use of antibiotics and proton pump inhibitors, hospitalization, and age, predispose individuals to C. difficile colonization and/or C. difficile infection. The gut microbiota of people with AC showed decreased abundances of Prevotella, Alistipes, Bacteroides, Bifidobacterium, Dorea, Coprococcus, and Roseburia. The gut microbiota of people suffering from CDI showed reductions in the abundances of Lachnospiraceae, Ruminococcaceae, Blautia spp., Prevotella spp., Dialister spp., Bifidobacterium spp., Roseburia spp., Anaerostipes spp., Faecalibacterium spp. and Coprococcus spp., in comparison with healthy people. Furthermore, increases in the abundances of Enterococcaceae and Enterococcus were associated with C. difficile infection.

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Section: Introductionmentioning

confidence: 99%

Gut Microbiota Composition Associated with Clostridioides difficile Colonization and Infection

et al. 2022

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Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

Di Bella,

Sanson,

Monticelli

et al. 2024

Clin Microbiol Rev

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SUMMARY Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections. This bacterium is constantly evolving and poses complex challenges for clinicians, often encountered in real-life scenarios. In the face of CDI, we are increasingly equipped with new therapeutic strategies, such as monoclonal antibodies and live biotherapeutic products, which need to be thoroughly understood to fully harness their benefits. Moreover, interesting options are currently under study for the future, including bacteriophages, vaccines, and antibiotic inhibitors. Surveillance and prevention strategies continue to play a pivotal role in limiting the spread of the infection. In this review, we aim to provide the reader with a comprehensive overview of epidemiological aspects, predisposing factors, clinical manifestations, diagnostic tools, and current and future prophylactic and therapeutic options for C. difficile infection.

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Association Between Immunosuppressive Therapy and Outcome of Clostridioides difficile Infection: Systematic Review and Meta-Analysis

Cited by 2 publications

References 62 publications

Gut Microbiota Composition Associated with Clostridioides difficile Colonization and Infection

Gut Microbiota Composition Associated with Clostridioides difficile Colonization and Infection

Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

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