Association between Immunosenescence, Mitochondrial Dysfunction and Frailty Syndrome in Older Adults

Buondonno, Ilaria; Sassi, Francesca; Cattaneo, Francesco

doi:10.3390/cells12010044

Cited by 5 publications

(3 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ilaria Buondonno et al. also reported decreased numbers of CD4+ and CD8+ T cells in frail subjects, while CD4+/CD8+, memory, and naive T cells were unaffected by frailty [ 51 ]. Interestingly, Gilda Varricchi et al.…”

Section: Discussionmentioning

confidence: 99%

Elucidating the causal nexus and immune mediation between frailty and chronic kidney disease: integrative multi-omics analysis

Zheng,

Cheng,

Wang

et al. 2024

Renal Failure

View full text Add to dashboard Cite

Background Empirical research has consistently documented the concurrent manifestation of frailty and chronic kidney disease (CKD). However, the existence of a reverse causal association or the influence of confounding variables on these correlations remains ambiguous. Methods Our analysis of 7,078 participants from National Health and Nutrition Examination Survey(NHANES) (1999–2018) applied weighted logistic regression and Mendelian Randomization (MR) to investigate the correlation between the frailty index (FI) and renal function. The multivariate MR analysis was specifically adjusted for type 2 diabetes and hypertension. Further analysis explored 3282 plasma proteins to link FI to CKD. A two-step network MR highlighted immune cells’ mediating roles in the FI-CKD relationship Result Genetically inferred FI and various renal function markers are significantly correlated, as supported by NHANES analyses. Multivariate MR analysis revealed a direct causal association between the FI and CKD. Additionally, our investigation into plasma proteins identified Tmprss11D and MICB correlated with FI and CKD, respectively. A two-step network MR to reveal 15 immune cell types, notably Central Memory CD4+ T cells and Lymphocytes, as crucial mediators between FI and CKD. Conclusion Our work establishes a causal connection between frailty and CKD, mediated by specific immune cell profiles. These findings highlight the importance of immune mechanisms in the frailty-CKD interplay and suggest that targeting shared risk factors and immune pathways could improve management strategies for these conditions. Our research contributes to a more nuanced understanding of frailty and CKD, offering new avenues for intervention and patient care in an aging population.

show abstract

Section: Discussionmentioning

confidence: 99%

Elucidating the causal nexus and immune mediation between frailty and chronic kidney disease: integrative multi-omics analysis

Zheng,

Cheng,

Wang

et al. 2024

Renal Failure

View full text Add to dashboard Cite

show abstract

“…Interestingly, frail people present an immune profile more senescent than robust people with a higher rate of terminally differentiated CD8 + CD28-T cells [ 28 , 29 ] and a lower IL-17 production after in vitro stimulation [ 29 ].…”

Section: The Impact Of Physiological Aging Focus On Immunosenescencementioning

confidence: 99%

The impact of age-related syndromes on ICU process and outcomes in very old patients

Vallet

Guidet

Boumendil

et al. 2023

Ann. Intensive Care

View full text Add to dashboard Cite

In this narrative review, we describe the most important age-related “syndromes” found in the old ICU patients. The syndromes are frailty, comorbidity, cognitive decline, malnutrition, sarcopenia, loss of functional autonomy, immunosenescence and inflam-ageing. The underlying geriatric condition, together with the admission diagnosis and the acute severity contribute to the short-term, but also to the long-term prognosis. Besides mortality, functional status and quality of life are major outcome variables. The geriatric assessment is a key tool for long-term qualitative outcome, while immediate severity accounts for acute mortality. A poor functional baseline reduces the chances of a successful outcome following ICU. This review emphasises the importance of using a geriatric assessment and considering the older patient as a whole, rather than the acute illness in isolation, when making decisions regarding intensive care treatment.

show abstract

“…The flu vaccination is undoubtedly that which has been studied and known for the longest time; it is known that when carried out annually, it is able to reduce complications, hospitalizations, and deaths due to this infection [ 28 , 29 ]. Although vaccine effectiveness may be lower in older adults than younger individuals due to age-related changes in the immune system, getting vaccinated can still provide significant benefits, reducing the risk of serious disease in less compromised older adults and minimizing the annual risk of frailty [ 30 , 31 ]. A meta-analysis showed that the flu vaccine was capable of inducing effective immunization in 51% of individuals up to 65 years of age and only 43% of people over 65 years of age [ 32 ].…”

Section: Efficacy Of Vaccines In the Elderlymentioning

confidence: 99%

Efficacy and Safety of Vaccinations in Geriatric Patients: A Literature Review

Ciarambino,

Crispino,

Buono

et al. 2023

Vaccines

View full text Add to dashboard Cite

With the progressive lengthening of the average age of the population, especially in some countries such as Italy, vaccination of the elderly is a fixed point on which most of the public health efforts are concentrating as epidemic infectious diseases, especially those of the winter, have a major impact on the progression of severe disease, hospitalization, and death. The protection of the elderly against acute infectious diseases should not only limit mortality but also have a positive impact on the fragility of these people in terms of less disability and fewer care needs. However, vaccination of the elderly population differs in efficacy and safety compared to that of other population categories since aging and the consequent loss of efficiency of the immune system lead to a reduction in the immunogenicity of vaccines without achieving a lasting antibody coverage. There are various strategies to avoid the failure of immunization by vaccines such as resorting to supplementary doses with adjuvant vaccines, increasing the dosage of the antigen used, or choosing to inoculate the serum relying on various routes of administration of the vaccine. Vaccination in the elderly is also an important factor in light of growing antibiotic resistance because it can indirectly contribute to combating antibiotic resistance, reducing theoretically the use of those agents. Furthermore, vaccination in old age reduces mortality from infectious diseases preventable with vaccines and reduces the same rate of resistance to antibiotics. Given the importance and complexity of the topic, in this review, we will deal with the main aspects of vaccination in the elderly and how it can influence mortality and healthcare costs, especially in those countries where population aging is more evident. Therefore, we conducted a systematic literature search in PubMed to identify all types of studies published up to 31 May 2023 that examined the association between vaccination and the elderly. Data extraction and quality assessment were conducted by two reviewers (PC and TC) who independently extracted the following data and assessed the quality of each study.

show abstract

Association between Immunosenescence, Mitochondrial Dysfunction and Frailty Syndrome in Older Adults

Cited by 5 publications

References 62 publications

Elucidating the causal nexus and immune mediation between frailty and chronic kidney disease: integrative multi-omics analysis

Elucidating the causal nexus and immune mediation between frailty and chronic kidney disease: integrative multi-omics analysis

The impact of age-related syndromes on ICU process and outcomes in very old patients

Efficacy and Safety of Vaccinations in Geriatric Patients: A Literature Review

Contact Info

Product

Resources

About