Association between IL4 (–590), ACE (I)/(D), CCR5 (Δ32), CTLA4 (+49) and IL1-RN (VNTR in intron 2) gene polymorphisms and vitiligo

Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP

“…(2004b) reported an association with the ACE region insertion–deletion (indel) rs1799752 ( ACE I/D) (allelic P = 1.2E-02). Three subsequent studies failed to replicate this association: a UK study of 106 non-Hispanic white cases and 174 controls (Akhtar et al ., 2005), an Indian study of 125 cases and 156 controls (Dwivedi et al ., 2008), and a Turkish study of 48 cases and 50 controls (Pehlivan et al ., 2009). Indel rs1799752 is not in HapMap, but is in complete LD ( D ′ = 1, r 2 = 0.86) with rs4343 (Abdollahi et al ., 2008).…”

Lack of association between cytotoxic T-lymphocyte antigen-4+49A/G polymorphism and psoriasis and vitiligo: A meta-analysis of case–control studies

“…In the present study, we found significant between-study heterogeneity in the overall analysis for psoriasis (Table 2), which was eliminated by deleting one study (Hao et al, 2003). Similarly, a single study (Pehlivan et al, 2009) appeared to be the major source of significant between-study heterogeneity in the analysis of CTLA-4 + 49A/G polymorphism and vitiligo. Furthermore, our data suggest that population background differences are the likely explanation for the heterogeneity in this meta-analysis because removing the single psoriasis (Hao et al, 2003) or vitiligo (Pehlivan et al, 2009) study significantly decreased the heterogeneity in the overall population but not in analyses stratified by ethnicity or HWE.…”

“…For vitiligo, although the removal of one study (Pehlivan et al, 2009) did not change the results during the sensitivity analysis, it resulted in disappearance of the significant between-study heterogeneity in all comparison models (I 2 = 0.0%) ( Table 3). The Begg's funnel plot and Egger's tests indicated the existence of publication bias in overall analysis using allele model (G vs. A) for seven studies (P Egger = 0.036, Fig.…”

“…Furthermore, individuals with the G/G genotype at position +49 show higher proliferation and Studies further excluded (n = 5): Not case-control study (n = 1) Reported duplicated data (n = 2) Not provided relevant data (n = 1) Not focus on the polymorphism of rs231775 (n = 1) 1 contained data on two different groups activation of T cells than the A/A genotype (Kouki et al, 2000;Maurer et al, 2002). Some studies have looked for a possible association between CTLA-4 + 49A/G polymorphism and psoriasis (Hao et al, 2003;Kim et al, 2003;Tsunemi et al, 2003;Luszczek et al, 2008;Fernandez-Mestre et al, 2009;Muto et al, 2011) or vitiligo (Blomhoff et al, 2005;Gao et al, 2005;Tang, 2007;Birlea et al, 2009;Pehlivan et al, 2009;Deeba et al, 2010;Dwivedi et al, 2011), but the findings have been (Hao et al, 2003) which may be the major source of the heterogeneity. b Statistically significant result.…”

Platelet-derived Growth Factor Receptor Alpha Gene Mutations in Vitiligo Vulgaris

“…At present, it is generally accepted that the pathogenesis of the disease is multifactorial and genetically heterogeneous (4). Mutations or polymorphisms in several genes have been associated with development of vitiligo (5)(6)(7)(8). However, together they account for only a small proportion of the genetic susceptibility for vitiligo.…”