Association between IL-17A, IL-17F and IL-17RA gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis

Villalpando-Vargas, Fridha Viridiana; Rivera-Valdés, Juan José; Alvarado-Navarro, Anabell; Huerta-Olvera, Selene G.; Macías-Barragán, José; Martínez-López, Érika; Graciano-Machuca, Omar

doi:10.1007/s00011-021-01514-6

Cited by 9 publications

(7 citation statements)

References 54 publications

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“…We have not identified any new genetic biomarkers useful in the diagnosis of PsA since the last meta-analyses on the subject, and these analyses on genetic polymorphisms had not identified any useful biomarkers for the practical diagnosis of PsA ( 135 , 136 ). Our systematic review did not identify all publications on HLA and PsA association, which may be due to the fact that our search algorithm was not specifically focused on genetics.…”

Section: Discussionmentioning

confidence: 98%

Biomarkers in psoriatic arthritis: A meta-analysis and systematic review

et al. 2022

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IntroductionPsoriatic arthritis (PsA) is a chronic inflammatory disease that frequently develops in patients with psoriasis (PsO) but can also occur spontaneously. As a result, PsA diagnosis and treatment is commonly delayed, or even missed outright due to the manifold of clinical presentations that patients often experience. This inevitably results in progressive articular damage to axial and peripheral joints and entheses. As such, patients with PsA frequently experience reduced expectancy and quality of life due to disability. More recently, research has aimed to improve PsA diagnosis and prognosis by identifying novel disease biomarkers.MethodsHere, we conducted a systematic review of the published literature on candidate biomarkers for PsA diagnosis and prognosis in MEDLINE(Pubmed), EMBase and the Cochrane library with the goal to identify clinically applicable PsA biomarkers. Meta-analyses were performed when a diagnostic bone and cartilage turnover biomarker was reported in 2 or moredifferent cohorts of PsA and control. ResultsWe identified 1444 publications and 124 studies met eligibility criteria. We highlighted bone and cartilage turnover biomarkers, genetic markers, and autoantibodies used for diagnostic purposes of PsA, as well as acute phase reactant markers and bone and cartilage turnover biomarkers for activity or prognostic severity purposes. Serum cartilage oligometrix metalloproteinase levels were significantly increased in the PsA sera compared to Healthy Control (HC) with a standardized mean difference (SMD) of 2.305 (95%CI 0.795-3.816, p=0.003) and compared to osteoarthritis (OA) with a SMD of 0.783 (95%CI 0.015-1.551, p=0.046). The pooled serum MMP-3 levels were significantly higher in PsA patients than in PsO patients with a SMD of 0.419 (95%CI 0.119-0.719; p=0.006), but no significant difference was highlighted when PsA were compared to HC. While we did not identify any new genetic biomarkers that would be useful in the diagnosis of PsA, recent data with autoantibodies appear to be promising in diagnosis, but no replication studies have been published. ConclusionIn summary, no specific diagnostic biomarkers for PsA were identified and further studies are needed to assess the performance of potential biomarkers that can distinguish PsA from OA and other chronic inflammatory diseases.

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Section: Discussionmentioning

confidence: 98%

Biomarkers in psoriatic arthritis: A meta-analysis and systematic review

et al. 2022

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“…Moreover, the IL17A gene variant has been linked to an increased risk of colorectal cancer in Asians and Caucasians [86,87], osteoarthritis in Caucasians [88], IgA nephropathy in Chinese Hans [89], polycystic ovarian syndrome in Chinese people [90], diabetic nephropathy in Iranians [91], diverse cancer in Asians [92], preeclampsia in Chinese people [93], and rheumatoid arthritis in Europeans [94]. However, IL17A polymorphism has been reported to show no association with many diseases, such as European and Asian psoriasis [95], Egyptian multiple myeloma [96], and Polish periodontitis [97].…”

Section: Discussionmentioning

confidence: 99%

Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage

Ali

Majid

Ali

et al. 2022

JCM

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Interleukin-17A (IL17A) is a proinflammatory cytokine and is assumed to play an important role in fetal rejection. In order to evaluate the potential role of IL17A polymorphism in the pathogenesis of recurrent miscarriage (RM), serum IL17A levels were estimated by ELISA. Single-nucleotide polymorphism was assessed by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) using gene-specific primers and the EcoNI restriction enzyme. Serum IL17A levels were nonsignificantly (p > 0.5) low in RM patients compared with the control group. IL17A gene amplification by PCR yielded the undigested product of 815 bp, and its digestion with EcoNI enzyme produced 815, 529, 286, and 270 bp fragments for the GG genotype; 529, 286, and 270 bp fragments for the GA genotype; and 529 and 286 bp fragments for the AA genotype. The genotype frequency between the RM and control groups exhibited a significant difference (p = 0.001), whereas no significant difference was observed between allele frequencies in the two groups (p = 0.0954). These data suggest that the IL17A gene polymorphism exhibits no significant effect on IL17A gene expression. However, it significantly decreases and increases RM risk in the homozygous and recessive models, suggesting its potential pregnancy-protecting and -harming roles in the AA and GA + GG genotypes, respectively.

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“… 47 The T allele and TT genotype of the IL-17F rs763780 polymorphism were associated with a decreased risk of psoriasis. 48 The IL-17F His161Arg polymorphism was significantly associated with psoriasis based on the genotype and allele analyses in an Asian population. 49 The IL17RA promoter region (rs4819554) was associated with psoriasis susceptibility in Egyptian psoriatic patients.…”

Section: The Immunogenetics Of Psoriasismentioning

confidence: 99%

Psoriasis: An Immunogenetic Perspective

Kocaaga

2022

Glob Med Genet

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Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease. Over the past two decades, numerous linkage analyzes and genome-wide association studies have been conducted to investigate the role of genetic variation in disease pathogenesis and progression. To date, >70 psoriasis susceptibility loci have been identified, including HLA-Cw6, IL12B, IL23R, and LCE3B/3C. Some genetic markers are used in clinical diagnosis, prognosis, treatment, and personalized new drug development that can further explain the pathogenesis of psoriasis. This review summarizes the immunological mechanisms involved in the etiopathogenesis of psoriasis and recent advances in susceptibility genes and highlights new potential targets for therapeutic intervention.

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Association between IL-17A, IL-17F and IL-17RA gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis

Cited by 9 publications

References 54 publications

Biomarkers in psoriatic arthritis: A meta-analysis and systematic review

Biomarkers in psoriatic arthritis: A meta-analysis and systematic review

Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage

Psoriasis: An Immunogenetic Perspective

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