Association between IL-13 +1923C/T polymorphism and asthma risk: a meta-analysis based on 26 case-control studies

Abstract

Asthma is a serious and hereditary respiratory disorder affecting all age groups. Interleukin-13 (IL-13) is a central regulator of allergic inflammation. The purpose of the present study was to estimate the relationship between IL-13 +1923C/T polymorphism and asthma susceptibility. Relevant case-control studies published between January 2000 and July 2016 were searched in the online databases. Review Manage (RevMan) 5.3 was used to conduct the statistical analysis. The pooled odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of association. A total of 26 articles were retrieved, including 17642 asthma patients and 42402 controls. Overall, our results found that IL-13 +1923C/T polymorphism was significantly associated with increased risk of asthma under each genetic model (P<0.00001). Subgroup analysis by ethnicity showed that alleles and genotypes of this variant correlated with asthma among Asians and Caucasians, but only TT genotype under the homozygote model in Africans. When stratified by age group, this variant highly correlated with asthma in children and moderately in adults. Furthermore, the TT, CT and CC genotypes in asthma group were all significantly associated with increased IgE levels in sera of asthma patients when compared with controls. Our results suggested that IL-13 +1923C/T polymorphism contributed to the development of asthma. Further case-control studies with more ethnicities are still needed.

Asthma susceptible genes in children

“…In line with these findings, we presume IL-13 +2044 A/G and IL-4 -590 C/T polymorphisms maybe potential susceptible predictor for pediatric asthma. However, some studies showed that IL-13 -1112C/T and +1923C/T polymorphisms were correlated with increased risk of asthma in children, [ 68 , 69 , 71 ] which is different from our results. The reasons may be as follows: on the one hand, a significantly increased risk between IL-13 -1112C/T and asthma risk was observed by Liu et al [ 68 ] in overall populations, but not in Asians or Chinese.…”

Asthma susceptible genes in children: A meta-analysis

“…In line with these ndings, we presume IL-13 + 2044 A/G and IL-4 -590 C/ T polymorphism maybe risk factors in pediatric asthma. However, some studies has shown that IL-13 -1112C/T and IL-13 + 1923C/T variant were correlated with increased risk of asthma in children 58,59,61 , which is different from our results. The reasons may be the following: a signi cantly increased risk between IL-13 -1112C/T and asthma risk was observed by Liu et al 58 in overall populations, but not in Asians.…”

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

“…Polymorphisms in IL-6 [68], IL-4 [69], high-affinity IgE receptor [70], IL-4R [71], disintegrin and metalloproteinase 33 [72], and IL-13 [73] have been associated with epithelial dismantling and malfunctioning, especially in the context of asthma and chronic obstructive pulmonary disease [74,75]. In this sense, a high level of IL-13 in asthmatic patients has been involved in wall remodeling processes [76,77].…”