Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population

Abstract

BackgroundIL-10 can play a vital role in immune response against HBV. Three biallelic SNPs from the transcription start site control the transcription of the IL-10 gene. An association between susceptibility to HBV and IL-10 polymorphisms has been suggested in patients with HBV infection.ObjectivesThe present study was designed to study the association between polymorphisms in interleukin-10 (-1082 A/G, -819 T/C and -592 A/C) promoter gene and chronic hepatitis B virus (HBV) infection.Patients and Methods221 chronically infected patients and 200 healthy control subjects were enrolled in the study. Three biallelic (-1082 A/G, -819 T/C and -592 A/C) polymorphisms in the IL-10 promoter gene were determined by PCR-RFLP method.ResultsPersistent HBV infection was associated with IL-10-1082 AG (P = 0.001) and GG (P = 0.004) genotypes and G (P = 0.000) allele. IL-10-819 T/C and -592 A/C genotype and allele frequencies did not show any correlation with the risk of chronic hepatitis B infection.ConclusionsThese results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of HBV infection and susceptibility to HBV infection.

Impact of host gene polymorphisms on susceptibility to chronic hepatitis B virus infection

“…IL-10 has pleiotropic effects on inflammation. It can regulate the expression of Th1 cytokines and MHC class II antigens and enhances the Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signaling pathway (Levings et al, 2001;Mosser and Zhang, 2008;Moudi et al, 2016). PROTECTION (Bellamy and Hill, 1998;Bellamy et al, 1999) IL-10 can suppress the host Th1 immune response by inhibiting the expression of pro-inflammatory cytokines such as IL-2, TNF-alpha and IFN-gamma in Th1 cells (Pestka et al, 2004).…”

Association of TNF-α Gene Polymorphisms with Production of Protein and Susceptibility to Chronic Hepatitis B Infection in the South East Iranian Population

“…The studies about the host immune responses indicated a significant association between the T-cell functions and infectious diseases (5). More recently, results suggest that chronic HBV infection is an immune related disease, and cellular immune activation was observed through some cytokines such as interleukin 10 (IL-10) (6) and interleukin 28 (IL-28) (7, 8), as well as macrophage migration factor (9). Cytokines play an effective role in host immune system.…”

Вміст Інтерлейкіну-10 У Сироватці Крові При Оперізувальному Герпесі У Дорослих Залежно Від Поліморфізму Його Гена

“…При розвитку локалізованої форми оперізувального герпесу ураження трійчастого нерва частіше реєструвалося у хворих з ТТ генотипом (84,8 % проти 15,2 %, χ 2 =6,36, Р=0,02), проте динаміка змін вмісту ІЛ-10 у сироватці крові цих пацієнтів не залежала від локалізації уражень. Встановлено, що генотип СС гена ІЛ-10 (rs1800896) частіше виявлявся у хворих на оперізувальний герпес з рецидивним перебігом (0,75 проти 0,261, χ 2 =4,19,OR=8,5, 95 % CI=0,(81)(82)(83)(84)(85)(86)(87)(88)(89)75). Вміст ІЛ-10 у сироватці крові хворих з рецидивним перебігом захворювання, на відміну від пацієнтів з первинною маніфестацією, характеризувався менш значущим його підвищенням (Р<0,05).Висновки.…”