Association Between<i>Toxoplasma gondii</i>Exposure and Heart Disease: A Case-Control Study

Alvarado‐Esquivel, Cosme; Salcedo-Jaquez, Misael; Sánchez‐Anguiano, Luis Francisco; Hernández‐Tinoco, Jesús; Rábago-Sánchez, Elizabeth; Beristaín-Garcia, Isabel; Liesenfeld, Oliver; Estrada-Martínez, Sergio; Pérez-Álamos, Alma Rosa; Alvarado-Soto, Ediyair

doi:10.14740/jocmr2525w

Cited by 19 publications

(28 citation statements)

References 27 publications

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“…Seropositivity to T . gondii was associated with alcohol consumption in patients with heart disease [ 14 ]. In two studies of decedents in Poland, researchers found a positive association between T .…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of Toxoplasma gondii infection in people with alcohol consumption in Durango, Mexico

Estrada-Martínez¹,

Pérez-Álamos²,

Ibarra-Segovia

et al. 2021

PLoS ONE

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The seroepidemiology of infection with Toxoplasma gondii (T. gondii) in alcohol consumers is largely undeveloped. In light of this, we sought to determine the seroprevalence of T. gondii infection in alcohol consumers in Durango, Mexico, and the association of T. gondii seroprevalence with characteristics of the population studied. Anti-T. gondii IgG and IgM antibodies were searched in sera of participants using commercially available enzyme immunoassays. Bivariate and logistic regression analyses were then used to determine the association between T. gondii infection and the characteristics of the population studied. Of the 1544 people studied (mean age: 39.4±14.0 years), 173 (11.2%) tested positive for anti-T. gondii IgG antibodies. We were able to test 167 of the 173 anti-T. gondii IgG positive sera for anti-T. gondii IgM antibodies. Fifty-five (32.9%) of these 167 serum samples were positive for anti-T. gondii IgM antibodies. Bivariate analysis showed that visual impairment, history of surgery, and hepatitis were negatively associated with T. gondii IgG seropositivity (P<0.05). In women, seropositivity to T. gondii was positively associated with a history of pregnancy (P<0.05). Logistic regression analysis showed that T. gondii seropositivity was associated with the variables consumption of armadillo meat (OR = 2.33; 95% CI: 1.04–5.22; P = 0.03), and the use of latrines for elimination of excretes (OR = 2.27; 95% CI: 1.07–4.80; P = 0.03); and high (>150 IU/ml) anti-T. gondii IgG antibodies were associated with consumption of both armadillo meat (OR = 2.25; 95% CI: 1.01–5.02; P = 0.04) and crowding at home (OR = 1.63; 95% CI: 1.02–2.61; P = 0.03). We found a distinct T. gondii seroprevalence in people with alcohol consumption from those previously found in population groups in the region. This is the first study that illustrates the association between high anti-T. gondii antibodies and crowding in Mexico, and the second study on the association between T. gondii infection and consumption of armadillo meat and the use of latrines in this country. We conclude that epidemiology of T. gondii infection in people with alcohol consumption deserves further investigation.

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Section: Introductionmentioning

confidence: 99%

Seroepidemiology of Toxoplasma gondii infection in people with alcohol consumption in Durango, Mexico

Estrada-Martínez¹,

Pérez-Álamos²,

Ibarra-Segovia

et al. 2021

PLoS ONE

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“…Toxoplasma gondii is an obligate intracellular protozoan parasite estimated to have infected one‐third of the world population (Pappas et al ; Alvarado‐Esquivel et al , ; Hill and Dubey, ). Toxoplasma is mainly acquired through consumption of undercooked meat from infected animals or by ingestion of environmental oocysts that are shed in the feces of infected felines, the definitive host.…”

Section: Introductionmentioning

confidence: 99%

TgDrpC, an atypical dynamin‐related protein in Toxoplasma gondii, is associated with vesicular transport factors and parasite division

Heredero‐Bermejo

Varberg

Charvat

et al. 2018

Molecular Microbiology

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Summary Dynamin-related proteins (Drps) are involved in diverse processes such as organelle division and vesicle trafficking. The intracellular parasite Toxoplasma gondii possesses three distinct Drps. TgDrpC, whose function remains unresolved, is unusual in that it lacks a conserved GTPase Effector Domain, which is typically required for function. Here, we show that TgDrpC localizes to cytoplasmic puncta; however, in dividing parasites, TgDrpC redistributes to the growing edge of the daughter cells. By conditional knockdown, we determined that loss of TgDrpC stalls division and leads to rapid deterioration of multiple organelles and the IMC. We also show that TgDrpC interacts with proteins that exhibit homology to those involved in vesicle transport, including members of the adaptor complex 2. Two of these proteins, a homolog of the adaptor protein 2 (AP-2) complex subunit alpha-1 and a homolog of the ezrin–radixin–moesin (ERM) family proteins, localize to puncta and associate with the daughter cells. Consistent with the association with vesicle transport proteins, re-distribution of TgDrpC to the IMC during division is dependent on post-Golgi trafficking. Together, these results support that TgDrpC contributes to vesicle trafficking and is critical for stability of parasite organelles and division.

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“… 3 However, individuals who develop toxoplasmosis, the disease caused by T. gondii , may present several well-recognized clinical features: lymphadenopathy, chorioretinitis, and meningoencephalitis. 4 , 5 In addition, infection with T. gondii has been associated with heart disease, 6 , 7 schizophrenia, 8 , 9 depression, 10 , 11 and mixed anxiety and depression. 12 Immunocompromised individuals infected with T. gondii may develop disseminated and life-threatening disease.…”

Section: Introductionmentioning

confidence: 99%

Association between Toxoplasma gondii infection and history of blood transfusion: a case-control seroprevalence study

et al. 2018

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ObjectivesThis study was performed to determine the association between seropositivity to Toxoplasma gondii and a history of blood transfusion.MethodsPatients who had undergone blood transfusion (n = 410) and age- and sex-matched controls who had not undergone blood transfusion (n = 1230) were examined for anti-T. gondii IgG and IgM antibodies using enzyme-linked immunoassays.ResultsAnti-T. gondii IgG antibodies were detected in 57 (13.9%) patients and in 129 (10.5%) controls with a borderline difference [odds ratio (OR) = 1.37, 95% confidence interval (CI) = 0.98–1.92]. High anti-T. gondii IgG antibody levels (>150 IU/mL) were found in 27 (47.4%) of the 57 anti-T. gondii IgG-positive patients and in 37 (28.7%) of the 129 anti-T. gondii IgG positive controls with a significant difference (OR = 2.23, 95% CI = 1.17–4.26). Anti-T. gondii IgM antibodies were found in 13 (22.8%) of the 57 seropositive patients and in 37 (28.7%) of the 129 seropositive controls, but the difference was not significant (OR = 0.73, 95% CI = 0.35–1.52). Seroprevalence was significantly higher in patients aged >50 years than in controls of the same age and in female patients than in female controls.ConclusionsThese findings indicate that a history of blood transfusion is a risk factor for T. gondii infection.

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Association BetweenToxoplasma gondiiExposure and Heart Disease: A Case-Control Study

Cited by 19 publications

References 27 publications

Seroepidemiology of Toxoplasma gondii infection in people with alcohol consumption in Durango, Mexico

Seroepidemiology of Toxoplasma gondii infection in people with alcohol consumption in Durango, Mexico

TgDrpC, an atypical dynamin‐related protein in Toxoplasma gondii, is associated with vesicular transport factors and parasite division

Association between Toxoplasma gondii infection and history of blood transfusion: a case-control seroprevalence study

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