Association between<i>RANK, RANKL</i>and<i>OPG</i>polymorphisms with ACPA and erosions in rheumatoid arthritis: results from a meta-analysis involving three French cohorts

Ruyssen‐Witrand, Adeline; Degboé, Yannick; Cantagrel, Alain; Nigon, Delphine; Lukas, Cédric; Scaramuzzino, Sara; Allanore, Yannick; Vittecoq, Olivier; Schaeverbeke, Thierry; Morel, Jacques; Sibilia, Jean; Cambon‐Thomsen, Anne; Dieudé, Philippe; Constantin, Arnaud

doi:10.1136/rmdopen-2015-000226

Cited by 16 publications

(19 citation statements)

References 28 publications

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“…As for RANKL SNPs investigated in our study, Ruyssen-Witrand et al ( 2016 ) described RANKL rs7325635 as significantly associated with anti-CCP antibody presence and erosions, whereas RANKL rs7988338 was significantly associated with femoral neck compression strength index, a phenotypic parameter integrating bone density, bone size, and body size, having significant potential to improve hip fracture risk assessment (Dong et al 2009 ).…”

Section: Discussionmentioning

confidence: 77%

Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment

Wielińska

Kolossa²,

Świerkot

et al. 2020

Arch. Immunol. Ther. Exp.

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Inconsistency of the results regarding the genetic variability within genes coding for receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) in rheumatoid arthritis (RA) prompted us to study the RANK and RANKL polymorphisms as potential biomarkers associated with disease predisposition and response to anti-TNF treatment in a group of Polish patients with RA. This study enrolled 318 RA patients and 163 controls. RANK (rs8086340, C > G; rs1805034, C > T) and RANKL (rs7325635, G > A; rs7988338 G > A) alleles were determined by real-time PCR with melting curve analysis and related with clinical parameters. In addition, RANKL serum levels were measured by ELISA. The RANK rs8086340-G allele was overrepresented among patients as compared to controls (OD = 1.777, p = 0.038). C-reactive protein (CRP) levels were significantly (p < 0.05) associated with RANK rs8086340 polymorphism and were higher in the CC-homozygotes at the baseline while lower in the GG-carriers at the 12th week of the treatment. At the latter time point RANKL rs7325635-GG-positive patients also showed significantly lower CRP concentrations. Higher alkaline phosphatase levels before induction of anti-TNF therapy were observed in RANK rs8086340 and RANK rs1805034 CC homozygotes (p = 0.057 and p = 0.035, respectively). The GG homozygosity of both RANKL single nucleotide polymorphisms was significantly associated with the number of swollen joints (rs7988338 and rs7325635, before and at the 12th week of therapy, respectively, p < 0.05 in both cases). These results imply that polymorphisms within the RANK and RANKL genes affect RA susceptibility and anti-TNF treatment outcome.

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Section: Discussionmentioning

confidence: 77%

Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment

Wielińska

Kolossa²,

Świerkot

et al. 2020

Arch. Immunol. Ther. Exp.

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“…However, after multivariate analysis, the polymorphism rs8086340 of the RANK gene was associated with the loss of orthodontic MIs. This polymorphism is located in the intron 1 and could have no functional effect on RANK , but it may play a role in the regulation of gene transcription or it may be in LD with other SNPs with potential functional effects . In addition, the C allele of this same polymorphism has also been shown associated with the anticitrullinated peptide antibody present in rheumatoid arthritis in the study of Ruyssen et al…”

Section: Discussionmentioning

confidence: 99%

RANK/RANKL/OPG gene polymorphisms and loss of orthodontic mini‐implants

Giacobbo

Perin

Pereira

et al. 2020

Orthod Craniofacial Res

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Objective To investigate the association of genetic polymorphisms (tagSNPs type) of RANK/RANKL/OPG genes with the loss of orthodontic mini‐implants (MIs). Setting and sample population One hundred and thirty‐five patients of both sexes, with mean age of 48.7 ± 10 (20‐76 years), were studied. The control group was composed of 104 patients, with no MI lost and functioning for at least 6 months and the case group, of 31 patients with at least one MI lost. Materials and methods Cells were obtained by mouthwash with 3% glucose solution for 1 minute and scraping the buccal mucosa with sterilized spatula. DNA was extracted from buccal epithelial cells with 10 M ammonium acetate and 1 mM EDTA. Genotyping was performed by the real‐time polymerase chain reaction (PCR) technique. Univariate and multivariate analyses were performed (P < .05). Results No markers were associated with MI loss after Benjamini and Hochberg false discovery rate correction of Univariate tests. In the multivariate analysis, the variables that associated with MI loss were the number of MIs installed (P < .000) and the polymorphism rs8086340 in the RANK gene (P = .018). Conclusion A higher number of MIs installed (P < .000) and polymorphism rs8086340 in the RANK gene (P = .018) were associated with loss of orthodontic MIs after multivariate analysis.

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“…Besides, rs1805034 and rs8086340 SNPs have already been explored in rheumatoid arthritis (RA). [18,19] The aim of the present study was to explore the associations of RANK gene rs1805034 and rs8086340 SNPs with OA risk in a Chinese Han population.…”

Section: Introductionmentioning

confidence: 99%

Effects of receptor activator nuclear factor κB gene polymorphisms on the susceptibility to knee osteoarthritis

Wang¹,

Luo

Tian³

et al. 2019

Medicine

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The present study aimed to explore genetic association of receptor activator nuclear factor κB (RANK) polymorphisms with individual susceptibility to knee osteoarthritis (OA) in different Kellgren–Lawrence (KL) grades. This case–control study included 138 knee OA patients and 145 healthy individuals. RANK rs1805034 and rs8086340 polymorphisms were genotyped through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The effects of RANK polymorphisms on knee OA risk were analyzed via χ 2 test or Fisher exact test, and the results were expressed using odds ratios (ORs) with corresponding 95% confidence intervals (CIs). The C allele of rs1805034 polymorphism had significantly higher frequency in knee OA patients than in controls ( P = .044), indicating that this allele could increase the risk of knee OA (OR = 1.424, 95% CI = 1.010–2.008). Besides, the CC genotype and C allele of the rs1805034 polymorphism were significantly associated with elevated risk of knee OA in moderate grade (CC vs TT: P = .018, OR = 3.071, 95% CI = 1.187–7.941; C vs T: P = .012, OR = 1.787, 95% CI = 1.131–2.823). However, rs8086340 polymorphism had no significant association with knee OA risk The C allele of RANK rs1805034 polymorphism is closely correlated with increased risk of knee OA, especially for moderate grade.

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Association betweenRANK, RANKLandOPGpolymorphisms with ACPA and erosions in rheumatoid arthritis: results from a meta-analysis involving three French cohorts

Cited by 16 publications

References 28 publications

Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment

Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment

RANK/RANKL/OPG gene polymorphisms and loss of orthodontic mini‐implants

Effects of receptor activator nuclear factor κB gene polymorphisms on the susceptibility to knee osteoarthritis

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